Results 141 to 150 of about 25,432,439 (260)

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source

OxLDL induced JNK phosphorylation is reduced in cd9 null macrophages.

, 2013
(A) Peritoneal macrophages from wild type, cd9 null and cd36 null mice were stimulated by oxidized LDL (50 µg/ml) for timed points from 0–30 minutes. Cells were then lysed and analyzed by western blot with antibodies to phosphor-JNK (top) or total JNK ...
Roy L. Silverstein (336900), Wenxin Huang (336899), Maria Febbraio (65515)   +2 more
core   +1 more source

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

Esketamine inhibits the c-Jun N-terminal kinase pathway in the spinal dorsal horn to relieve bone cancer pain in rats

Molecular Pain
Cancer-induced bone pain (CIBP) is one of the most common and feared symptoms in patients with advanced tumors. The X-C motif chemokine ligand 12 (CXCL12) and the CXCR4 receptor have been associated with glial cell activation in bone cancer pain ...
Chenxia Duan, Yi Zhu, Zhuoliang Zhang, Tiantian Wu, Mengwei Shen, Jinfu Xu, Wenxin Gao, Jianhua Pan, Lei Wei, Huibin Su, Chenghuan Shi   +10 more
doaj   +1 more source

Drosophila male genitalia rotation depends on permissive remodeling of the posterior abdomen

Developmental Dynamics, EarlyView.
Abstract Background One of the most characteristic morphogenetic processes in Drosophila is the 360° rotation of the male pupal genital disc. This movement is driven by the myosin Myo1D, whose expression in the genital disc is controlled by the Hox gene Abdominal‐B (Abd‐B).
Nuria Prieto, David Foronda, Paloma Martín, Eléanor Simon, Marcus Bischoff, Stéphane Noselli, Ernesto Sánchez‐Herrero   +6 more
wiley   +1 more source

Diversin depletion inhibited and its overexpression promoted cell proliferation and invasion and JNK phosphorylation.

, 2014
A. Colony formation assay showed that diversin knockdown inhibited proliferation in MDA-MB-231 cell line and its overexpression promoted proliferation in MCF-7 cell line. B.
Minghao Wang (568133), Xinmiao Yu (568132), Qianze Dong (164522), Feng Jin (303721)   +3 more
core   +1 more source

Anti‐Inflammatory Effects of Punicic Acid and Its Molecular Mechanisms in RAW264.7 Cells and Zebrafish

Food Safety and Health, EarlyView.
Punicic acid (PA) was enriched and purified from PSO by molecular distillation with significant anti‐inflammatory activity to RAW264.7 cells, as well as to zebrafish. Anti‐inflammatory mechanism involved regulating NF‐κB and MAPK signaling pathways. ABSTRACT Punicic acid (PA) is the main fatty acid in pomegranate seeds, which shows multiple biological ...
Mengqi Zhang, Caiyun Feng, Mengyao Zhu, Xu Guo, Yingying Chen, Wenwen Hu, Fei Dong, Jinyue Sun, Chao Liu   +8 more
wiley   +1 more source

JNK activity is induced by ethanol

, 2013
A, B. Western blot analysis of brain lysates from Taok3Gt/+ and wild-type control mice showing induction of phospho-JNK by ethanol in wild-type mice and increased phospho-JNK levels in brains of saline-treated Taok3Gt/+ mice relative to controls ...
David Kapfhamer (295513), Fred W. Wolf (251155), Ulrike Heberlein (26491), Jana P. Lim (256963), Mimi E. Zou (295516), Ian King (377010)   +5 more
core   +1 more source