Results 101 to 110 of about 25,432,439 (260)

Kymograph of JNK* activity.

, 2014
Kymograph plots of JNK* activity (red = low, yellow/white = high) for (a) and (b) . Comparison between (a) and (b) reveals that JNK that is scaffolded and transported on the cytoskeleton (case (b)) can result in delivery of JNK and activation to JNK* at
Yen Ling Koon (545418), Keng-Hwee Chiam (535233), Cheng Gee Koh (545419)   +2 more
core   +1 more source

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro

Neuroscience Letters, 2014
Mitogen-activated protein kinases (MAPKs) play critical roles in the central nervous system immune responses through glial function, which are regulated with relative selectivity (or preference) by MAPK phosphatases (MKP). Phosphorylated extracellular signal-regulated protein kinase (p-ERK) is preferentially dephosphorylated by MKP-3, which display ...
Christian, Ndong, Russell P, Landry, Madhurima, Saha, E Alfonso, Romero-Sandoval   +3 more
openaire   +3 more sources

RCECs p-JNK (I), phosphorylated-NF-κβ (II) and cultured medium IL-1β(III) levels.

, 2013
RCECs cultured in NOP (normal osmotic pressure, 312mOsM) (A), HOP (high osmotic pressure, 500mOsM) (B), HOP+NAC (10 mM) (C), HOP+ DPI (10 µM) (D), HOP+ JNK inhibitor SP600125 (25 µM) (E) and HOP+ NF−kB inhibitor Bay11-7082(5 µM) (F) for 24 h.
Yihui Chen (446576), Min Li (12799), Weifang Wang (421565), Anjuan Lin (446577), Bing Li (43671), Minjie Sheng (446578)   +5 more
core   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

Transfection of shRNA-JNK inhibited cantharidin-induced JNK phosphorylation in SAS human tongue carcinoma cells.

, 2016
(A) Cells were transfected with sh-control (siRNA-con) or shRNA-JNK for 48 h, and the JNK-1 mRNA expression was detected by qPCR analysis. Data are presented as mean ± SEM of three independent experiments.
Kuan-I Lee (3387842), Chun-Ying Kuo (3387839), Mu-Kuan Chen (155094), Chih-Hsin Tang (104506), Chin-Chuan Su (279690), Shing Hwa Liu (38213)   +5 more
core   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

PPARγ agonists induce JNK activation on primary hippocampal neurons.

, 2013
(A) Hippocampal neurons were treated with TGZ (10 µM) and RGZ (10 µM), in the presence or absence of SP (100 nM) for 72 h. After treatment neurons were fixed and double immunolabeled with anti-p-JNK (green) and anti-tau-1 (red) antibodies, respectively ...
Deny Cabezas (417322), Rodrigo A. Quintanilla (417320), Ivan Alfaro (417321), Miguel Bronfman (231091), Juan A. Godoy (304392), Rommy von Bernhardi (417323), Nibaldo C. Inestrosa (304394)   +6 more
core   +1 more source

JNK regulates FoxO-dependent autophagy in neurons [PDF]

, 2016
The cJun N-terminal kinase (JNK) signal transduction pathway is implicated in the regulation of neuronal function. JNK is encoded by three genes that play partially redundant roles.
Reilly, Judith, Davis, Roger J., Das, Madhumita, Xu, Ping   +3 more
core   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source