Results 101 to 110 of about 18,638,167 (297)

P-selectin expression tracks cerebral atrophy in Mexican-Americans

Frontiers in Genetics, 2012
Background and Purpose. We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure (BP) and cerebral atrophy.
Peter eKochunov, David eGlahn, Elliott eHong, Jack L Lancaster, Joanne eCurran, Matthew eJohnson, Anderson eWinkler, Henry eHolcomb, Jack eKent, Braxton eMitchell, Valeria eKochunov, Rene eOlvera, Shelley eCole, Thomas eDyer, Eric eMoses, Harald eGoring, Laura eAlmasy, Ravi eDuggirala, John eBlangero   +18 more
doaj   +1 more source

Sequential contribution of L- and P-selectin to leukocyte rolling in vivo

Journal of Experimental Medicine, 1995
Leukocyte recruitment into inflammatory sites is initiated by a reversible transient adhesive contact with the endothelium called leukocyte rolling, which is thought to be mediated by the selectin family of adhesion molecules.
K. Ley, D. Bullard, Maria L Arbon~s, R. Bosse, D. Vestweber, T. Tedder, A. Beaudet   +6 more
semanticscholar   +1 more source

In Vivo Measurement of Blood Clot Mechanics from Computational Fluid Dynamics based on Intravital Microscopy Images

, 2018
Ischemia leading to heart attacks and strokes is the major cause of deaths in the world. Whether an occlusion occurs or not, depends on the ability of a growing thrombus to resist forces exerted on its structure.
Chandran, Vishnu Deep, Kadri, Olufemi Emmanuel, Surblyte, Migle, Voronov, Roman S.   +3 more
core   +1 more source

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

Association between Endothelial Selectin (E-selectin) gene polymorphisms and E-selectin level with visceral leishmaniais, in an ARMS-PCR based study [PDF]

, 2008
Background: In the visceral leishmaniasis (VL), parasites reside in reticuluendothelial system, mainly in macrophages. Endothelial Selectin (E-selectin) might play an important role in leukocyte-endothelium interactions and inflammatory cell recruitment.
Bazmani, A., Fallah, M., Hajilooi, M., Mazloumi Gavgani, A., Taherkhani, H.   +4 more
core  

Systemic inflammation, body composition, and physical performance in old community-dwellers [PDF]

, 2017
Background Chronic inflammation, changes in body composition, and declining physical function are hallmarks of the ageing process. The aim of the present study was to provide a preliminary characterisation of the relationship among these age-related ...
Addison, Addison, Bandeen-Roche, Buford, Calvani, Cesari, De Martinis, Deng, Dong, Franceschi, Goodpaster, Guralnik, Haehling, Hsu, Hughes, Hughes, Jiang, Jo, Lau, Liao, Marzetti, Marzetti, Marzetti, Opal, Peterson, Prokopchuk, Roubenoff, Seals, Szymańska, Tuttle, Varadhan, Westerhuis, Westerhuis, Zoico   +33 more
core   +2 more sources

Inflammatory roles of P-selectin. [PDF]

Journal of Clinical Investigation, 1993
Polymorphonuclear leukocytes (PMNs) bind rapidly and reversibly to endothelial cells induced to express P-selectin, a glycoprotein that mediates adhesive intercellular interactions. In addition, PMNs adherent to endothelium expressing P-selectin demonstrate an intracellular Ca2+ transient, functionally up-regulate beta-2-integrins (CD11/CD18 ...
D E, Lorant, M K, Topham, R E, Whatley, R P, McEver, T M, McIntyre, S M, Prescott, G A, Zimmerman   +6 more
openaire   +2 more sources

Revisiting Incomplete Tissue‐Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke

Annals of Neurology, EarlyView.
Among patients with acute ischemic stroke achieving successful large vessel recanalization (defined as expanded Thrombolysis in Cerebral Infarction [eTICI ≥2b]), incomplete tissue‐level reperfusion, distinct from visually identifiable distal occlusion on digital‐subtraction angiography, remains a significant challenge.
Yue Qiao, Adrien Ter Schiphorst, Yi Xu, Jean‐Claude Baron, Wenbo Zhao   +4 more
wiley   +1 more source

Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach

Acta Medica Indonesiana
Background: Studies regarding hypercoagulation in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) patients have produced conflicting results.
Syntia Nusanti, Andhika Rachman, Brigitta Marcia Budihardja, Lourisa Ruth Eldinia, Nadia Delima Andini, Arief Kartasasmita, M Sidik, Seskoati Prayitnaningsih, Alida Roswita Harahap, Aria Kekalih, Tjahjono Darminto Gondhowiardjo   +10 more
doaj   +2 more sources

Nuclear Factor-κB-Independent Anti-Inflammatory Action of Salicylate in Human Endothelial Cells [PDF]

, 2006
In contrast to aspirin, salicylate, its active metabolite, possesses profound anti-inflammatory properties without blocking cyclooxygenase. Inhibition of the transcription factor nuclear factor-κB (NF-κB) has been discussed to play a role in the anti ...
Blumenthal, Signe B., Fürst, Robert, Kiemer, Alexandra K., Vollmar, Angelika M., Zahler, Stefan   +4 more
core   +1 more source