Results 141 to 150 of about 18,638,167 (297)

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

P-selectin levels in women with endometriosis and non-endometriosis

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2017
The discovery of a decline in the cellular immune system in endometrial tissue of women with endometriosis triggers the idea that immunologic factors may play a role in the process of endometriosis.
Tonny Simarmata
doaj  

Inflammation and endothelial activation in benign prostatic hyperplasia and prostate cancer

International Brazilian Journal of Urology, 2011
PURPOSE: Emerging insights underline a link among chronic inflammation and endothelial activation with benign prostatic hyperplasia (BPH) and prostate cancer (PCa).
Gianna Pace, Caterina Di Massimo, Daniela De Amicis, Carlo Vicentini, M. Giuliana Tozzi Ciancarelli   +4 more
doaj   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Crohn's lymphoid aggregates with endothelial clusters colocalise with submucosal fibrosis in fibrostenosing Crohn's disease

The Journal of Pathology, EarlyView.
Abstract Crohn's disease (CD) involves chronic transmural inflammation of the intestines, leading to progressive wall fibrosis with stenosis and luminal obstruction, predominantly in the terminal ileum. Fibrosis is a significant therapeutic challenge, thus improved understanding of localisation, cellular composition, and cell–cell interactions in CD ...
Michael Glinka, Gregory J Wickham, Francesca Nadalin, Kathryn J Kirkwood, Helen Caldwell, Mike Wicks, Bill Hill, Derek Houghton, Mehran Sharghi, Amirhosein Kefayat, Bernard Haggarty, Albert Burger, Richard A Baldock, David J Adams, Irene Papatheodorou, Peter Bankhead, Shahida Din, Mark J Arends   +17 more
wiley   +1 more source

Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation

Small, EarlyView.
This study presents a comparative analysis of heparin (HP)‐ and dextran sulfate (DS)‐coated superparamagnetic iron oxide nanoparticles (SPIONs) as a tunable immunomodulatory platform where surface chemistry dictates therapeutic function. DS‐SPIONs are preferentially internalized by myeloid cells, reprogramming them into a pro‐healing M2 phenotype ...
Negin Pournoori, Heela Sarlus, Dick J. Sjöström, Rohith Pavan Parvathaneni, Oommen P. Varghese, Vesa P. Hytönen, Robert A. Harris, Per H. Nilsson, Oommen P. Oommen   +8 more
wiley   +1 more source

Selective Membrane Protein Enrichment Enables Defined Biomimetic Nanoparticles for Endothelial Targeting

Small, EarlyView.
Particular nanoparticles (PNPs), engineered with defined enrichment of leukocyte adhesion membrane proteins, demonstrate superior targeting of inflamed sites in a microfluidic inflamed vessel model under flow conditions. This selective membrane protein enrichment enhances targeting efficiency while improving nanoparticle production reproducibility and ...
Sivan Arber Raviv, Rawan Mhajne, Maayan Ben‐Eliezer, Tamar Gross Lev, Assaf Zinger   +4 more
wiley   +1 more source

Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy

Allergy, EarlyView.
We investigated cell types mediating the early and late inflammatory responses in human Ni2+‐allergy by scRNA‐Seq. Early responsiveness was mainly mediated by TLR4+TAGLN− endothelial cells indirectly activating TLR4−KRT16+ keratinocytes, and CCR7+DCN+ DCs. Late responsiveness was crucially driven by infiltration of KLF2+ central memory T cells and TLR4+
Marc Schmidt, Andrea Knorz, Katharina Meder, Simon Goller, Fabian Imdahl, Yamila Rocca, Matthias Goebeler, Pierre Khoueiry   +7 more
wiley   +1 more source

Vessel‐associated microglia are differentially activated and distributed in relation to systemic infection and Alzheimer's disease

Brain Pathology, EarlyView.
This post‐mortem study revealed an increased density of vessel‐associated microglia (VAM) in the temporal lobe in systemic infection and Alzheimer's disease. VAM density was related to brain cytokine levels and markers of cerebrovascular dysfunction and BBB leakage indicating that activated VAM contributes to neurovascular injury in Alzheimer's disease.
Oliver Milner, Robert A. Fisher, Daniel J. Asby, Stephen Cross, Delphine Boche, J. Scott Miners   +5 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source