Results 31 to 40 of about 18,638,167 (297)

Platelet P-selectin triggers rapid surface exposure of tissue factor in monocytes

Scientific Reports, 2019
Tissue factor (TF) plays a central role in haemostasis and thrombosis. Following vascular damage, vessel wall TF initiates the extrinsic coagulation cascade. TF can also be exposed by monocytes. Inflammatory or infectious stimuli trigger synthesis of new
Ivelin Ivanov, B. Apta, A. Bonna, M. Harper   +3 more
semanticscholar   +1 more source

Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders [PDF]

, 2018
Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel.
Adamany J, Bath PM, May J, Flaherty K, Woodhouse LJ, Dovlatova N, Fox SC, England TJ, Krishnan K, Robinson TG, Sprigg N, et al., Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, et al., Cardoso RN, Benjo AM, DiNicolantonio JJ, Garcia DC, Macedo FY, El-Hayek G, Nadkarni GN, Gili S, Iannaccone M, Konstantinidis I, et al., Dovlatova N, Fox SC, May JA, Dovlatova N, Glenn JR, Johnson A, White AE, Radhakrishnan A, Heptinstall S., Heptinstall S, Heptinstall S, Heptinstall S, Jane May, Laohathai P, Joshi R, Radhakrishnan A, May J, Dovlatova N, Heptinstall S, Fox S., May J, Philip M Bath, Stan Heptinstall, TARDIS Trial Investigators, Krishnan K, Beridze M, Christensen H, Dineen R, Duley L, Heptinstall S, James M, Markus H, Pocock S, et al., Vlachojannis G   +15 more
core   +2 more sources

Soluble P- and E-selectin levels as determinants of vaso-occlusive crises among sickle cell anemia patients in a tertiary hospital Northwestern Nigeria

Iraqi Journal of Hematology, 2020
BACKGROUND: Vascular E- and P-selectins play important roles in sickle cell anemia (SCA), vaso-occlusive crises (VOC); however, the extent to which they determine VOC has not been studied.
Sani Awwalu, Abdulaziz Hassan, Aisha Indo Mamman, Abdul Wahab Alhassan, Ismaila Nda Ibrahim, Ibrahim Usman Kusfa, Aliyu Dahiru Waziri   +6 more
doaj   +1 more source

Vascular endothelial cell expression of JAK2V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression

Haematologica, 2018
Thrombosis is the main cause of morbidity and mortality in patients with JAK2V617F myeloproliferative neoplasms. Recent studies have reported the presence of JAK2V617F in endothelial cells of some patients with myeloproliferative neoplasms.
Alexandre Guy, V. Gourdou-Latyszenok, Nicolas Le Lay, Claire R. Peghaire, B. Kilani, J. Dias, C. Duplàa, M. Renault, C. Denis, J. Villeval, Y. Boulaftali, M. Jandrot-Perrus, T. Couffinhal, C. James   +13 more
semanticscholar   +1 more source

Biodistribution of P-selectin targeted microbubbles [PDF]

Journal of Drug Targeting, 2014
To evaluate binding of P-selectin targeted microbubbles (MB) in tumor vasculature; a whole-body imaging and biodistribution study was performed in a tumor bearing mouse model.Antibodies were radiolabeled with Tc-99 m using the HYNIC method. Tc-99 m labeled anti-P-selectin antibodies were avidin-bound to lipid-shelled, perfluorocarbon gas-filled MB and ...
Jason M, Warram, Anna G, Sorace, Marshall, Mahoney, Sharon, Samuel, Bryant, Harbin, Madhura, Joshi, Amber, Martin, Lee, Whitworth, Kenneth, Hoyt, Kurt R, Zinn   +9 more
openaire   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Plasma P-selectin level is associated with severity of coronary heart disease in Chinese Han population

Journal of International Medical Research, 2020
Objective This study aimed to evaluate the association between plasma P-selectin levels and the severity of coronary heart disease (CHD) in a Chinese Han population.
Chunhui Song, Guohai Wu, Sheng Chang, Lizhan Bie   +3 more
doaj   +1 more source

The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway

Cell Death and Disease, 2019
P-selectin and dendritic cells (DCs) are associated with atherosclerosis. However, their interactions in this setting are undefined. Herein, we investigated the role of P-selectin and its receptor P-selectin glycoprotein ligand (PSGL)-1 on ...
Z. Ye, Lei Zhong, Shengnan Zhu, Yinuo Wang, Jie Zheng, Shujing Wang, Jianing Zhang, Rong-chong Huang   +7 more
semanticscholar   +1 more source

Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study [PDF]

, 2008
We investigated whether chronic rosuvastatin administration could improve the abnormalities of the circulating levels of vascular dysfunction markers in pulmonary arterial hypertension (PAH).
BARRETO, A.C., CÍCERO, C., LOPES, A.A., MAEDA, N.Y., SOARES, R.P.S.   +4 more
core   +2 more sources

P‐selectin in haemostasis [PDF]

British Journal of Haematology, 2004
SummaryDuring the past decade, interrelationships between inflammation and thrombosis have been the subject of extensive works, and it is now commonly recognized that inflammation (notably leucocyte recruitment) directly affects thrombosis, and that thrombosis also constitutes a pro‐inflammatory event.
openaire   +2 more sources