Results 101 to 110 of about 20,152,363 (248)
Transfer Learning Approaches in Bioprocess Engineering: Opportunities and Challenges
Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1417-1431, June 2026.ABSTRACT Transfer learning (TL) has recently emerged as a promising approach to overcoming one of the key limitations of bioprocess engineering: data scarcity. By leveraging knowledge from one bioprocess to another, TL allows existing models and data sets to be reused efficiently, accelerating process development, improving prediction accuracy, and ...
Daniel Barón Díaz +3 more
wiley +1 more source
Synthetic and Systems Biotechnology2′-fucosyllactose (2′-FL) holds significant role in the infants' nutrition. While microbial production of 2′-FL has predominantly utilized Escherichia coli and Saccharomyces cerevisiae, the potential of Pichia pastoris, renowned for its robust NADPH ...
Yi Li +6 more
doaj +1 more source
Comparing the expression of human DNA topoisomerase I in KM71H and X33 strains of Pichia pastoris
Electronic Journal of Biotechnology, 2016 Background: Human is an essential cellular enzyme that is found in all human cells. As this enzyme is upregulated in cancer cells exceedingly, it is used as a target for cancer chemotherapeutic drug development. As such, producing the in-house enzyme for
Ruo Ping Ang +4 more
doaj +1 more source
Scientific Reports, 2020 The yeast Pichia pastoris is a cost-effective and easily scalable system for recombinant protein production. In this work we compared the conformation of the receptor binding domain (RBD) from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 ...
Argentinian AntiCovid Consortium
doaj +1 more source
Pyruvate dehydrogenase deficiency in a child responsive to thiamine treatment
, 1996 We report the clinical features in a 4-year-old child who was investigated for a suspected metabolic disorder but was subsequently diagnosed as having a pyruvate dehydrogenase deficiency.
Pastoris O +4 more
core +1 more source
Optimizing Pichia Pastoris Cell‐Free Protein Synthesis to Improve Economics
Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1708-1720, June 2026.ABSTRACT Cell‐free protein synthesis (CFPS) is a powerful and versatile platform that supports a wide range of applications, from fundamental studies of the genetic code to scalable and rapid protein production. The recently developed Pichia pastoris CFPS combines advantages of both prokaryotic and eukaryotic systems, including a rapid growth rate ...
Rui Wu +4 more
wiley +1 more source
Somatic genome‐doubling is the most parsimonious route to allopolyploidy
New Phytologist, Volume 250, Issue 5, Page 2845-2851, June 2026.Summary The origin of a polyploid can hinge on a single errant cell division, a mistake in the cell cycle that leads to genome‐doubling and re‐writes the rules of chromosome pairing and segregation. In plants, the evolutionary significance of these errors is magnified by lack of an early sequestered germline, meaning somatic mutations can be heritable.
Robin Burns +2 more
wiley +1 more source
Nature Biotechnology, 2019 The methylotrophic yeast Pichia pastoris is widely used in the manufacture of industrial enzymes and pharmaceuticals. Like most biotechnological production hosts, P.
T. Gassler +8 more
semanticscholar +1 more source
Vector for Pop-In/Pop-Out Gene Replacement in Pichia pastoris
BioTechniques, 2001 Gene replacement in yeast is often accomplished by using a counterselectable marker such as URA3. Although ura3 strains of Pichia pastoris have been generated, these strains are inconvenient to work with because they grow slowly, even in the presence of ...
Jon Soderholm +2 more
doaj +1 more source
Recombinant gelatin and collagen from methylotrophic yeasts
, 2002 Based on its structural role and compatibility within the human body, collagen is a commonly used biomaterial in medical applications, such as cosmetic surgery, wound treatment and tissue engineering.
Bruin, E.C., de
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