Results 31 to 40 of about 27,075 (176)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Heritability of P. falciparum and P. vivax Malaria in a Karen Population in Thailand

PLoS ONE, 2008
ركزت غالبية الدراسات المتعلقة بعلم الوراثة المضيفة للملاريا على الجينات الفردية التي تمنح الحماية ضد الملاريا بدلاً من التعرض لها. إن تحديد التأثير النسبي للعوامل الوراثية مقابل العوامل غير الوراثية على عدوى الملاريا ومرضها أمر ضروري لتركيز الجهود على العوامل المحددة الرئيسية.
Waraphon Phimpraphi, Paul Rácz, Bhee Witoonpanich, Chairat Turbpaiboon, Chayanon Peerapittayamongkol, Chalisa Louicharoen, Isabelle Casadémont, Sumalee Tungpradabkul, Srivicha Krudsood, Jaranit Kaewkunwal, Thanyachai Sura, Sornchai Looareesuwan, Pratap Singhasivanon, Anavaj Sakuntabhai   +13 more
openaire   +5 more sources

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Primaquine Reduces P vivax Parasitemia Risk

Molecular Medicine Communications, 2023
In areas where both P falciparum and P vivax are co-endemic, and a patient is diagnosed with P falciparum malaria, the standard practice is to treat the acute infection with an appropriate antimalarial, often an Artemisinin-based combination therapy (ACT). Primaquine is not typically used for treating the acute P falciparum infection.
openaire   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

The Plasmodium vivax Merozoite Surface Protein 1 Paralog Is a Novel Erythrocyte-Binding Ligand of P. vivax [PDF]

Infection and Immunity, 2013
ABSTRACT Merozoite surface protein 1 of Plasmodium vivax (PvMSP1), a glycosylphosphatidylinositol-anchored protein (GPI-AP), is a malaria vaccine candidate for P. vivax . The paralog of PvMSP1, named P.
Yang, Cheng, Yue, Wang, Daisuke, Ito, Deok-Hoon, Kong, Kwon-Soo, Ha, Jun-Hu, Chen, Feng, Lu, Jian, Li, Bo, Wang, Eizo, Takashima, Jetsumon, Sattabongkot, Takafumi, Tsuboi, Eun-Taek, Han   +12 more
openaire   +2 more sources

Duffy blood group genotypes among malaria patients in Rondônia, Western Brazilian Amazon Genótipos do sistema sanguíneo Duffy em pacientes maláricos de Rondônia, Amazônia Ocidental Brasileira

Revista da Sociedade Brasileira de Medicina Tropical, 2001
We have compared Duffy blood group genotype distribution, as determined by polymerase chain reaction with allele-specific primers, in 68 Plasmodium vivax-infected patients and 59 non-vivax malaria controls from Rondônia, Brazil.
Carlos Eugênio Cavasini, Fabrício José Tarelho Pereira, Weber Luidi Ribeiro, Gerhard Wunderlich, Marcelo Urbano Ferreira   +4 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Whole genome sequencing of field isolates reveals a common duplication of the Duffy binding protein gene in Malagasy Plasmodium vivax strains. [PDF]

PLoS Neglected Tropical Diseases, 2013
Plasmodium vivax is the most prevalent human malaria parasite, causing serious public health problems in malaria-endemic countries. Until recently the Duffy-negative blood group phenotype was considered to confer resistance to vivax malaria for most ...
Didier Menard, Ernest R Chan, Christophe Benedet, Arsène Ratsimbasoa, Saorin Kim, Pheaktra Chim, Catherine Do, Benoit Witkowski, Remy Durand, Marc Thellier, Carlo Severini, Eric Legrand, Lise Musset, Bakri Y M Nour, Odile Mercereau-Puijalon, David Serre, Peter A Zimmerman   +16 more
doaj   +1 more source

Validation of Health Belief Model and Theory of Planned Behaviour Constructs for Predicting Malaria Vaccine Acceptance in Ghana: A Partial Least Squares Structural Equation Modelling Approach

Tropical Medicine &International Health, EarlyView.
ABSTRACT Aim This study examines the predictive power of constructs from the health belief model (HBM) and theory of planned behaviour (TPB) in explaining malaria vaccine acceptance in Ghana in the post‐COVID‐19 era, while also assessing the reliability of these constructs within this context.
Michael Sarfo, Michael Snowden, Jamie P. Halsall   +2 more
wiley   +1 more source