Results 91 to 100 of about 7,902 (230)

Biophysical properties of intrinsically disordered p130Cas substrate domain--implication in mechanosensing.

PLoS Computational Biology, 2014
Mechanical stretch-induced tyrosine phosphorylation in the proline-rich 306-residue substrate domain (CasSD) of p130Cas (or BCAR1) has eluded an experimentally validated structural understanding.
Kinya Hotta, Soumya Ranganathan, Ruchuan Liu, Fei Wu, Hiroaki Machiyama, Rong Gao, Hiroaki Hirata, Neelesh Soni, Takashi Ohe, Christopher W V Hogue, M S Madhusudhan, Yasuhiro Sawada   +11 more
doaj   +1 more source

Mechanosensors in integrin signaling: The emerging role of p130Cas

European Journal of Cell Biology, 2014
Physicochemical interactions between the cell and its environment are crucial for morphogenesis, tissue homeostasis, remodeling and pathogenesis. Cells form specialized structures like focal adhesions and podosomes that are responsible for bi-directional information exchange between the cell and its surroundings.
Janoštiak, Radoslav, Pataki, Andreea Csilla, Brábek, Jan, Rösel, Daniel   +3 more
openaire   +2 more sources

LncRNA FAISL Inhibits Calpain 2‐Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer

Advanced Science, Volume 11, Issue 42, November 13, 2024.
An FAK interacting and stabilizing lncRNA (FAISL) is identified, which binds FAK C‐terminus and prevents Calpain 2‐mediated FAK proteolysis. FAISL overexpression correlates with poor prognosis of triple negative breast cancer (TNBC) patients and resembles FAK‐induced phenotypes in TNBC cells.
Yunmei Zhang, Shiyu Wei, Zhengjie Chen, Rui Xu, Shu‐Rong Li, Lili You, Ruiyue Wu, Yin Zhang, Jian‐You Liao, Xiaoding Xu, Erwei Song, Man‐Li Luo   +11 more
wiley   +1 more source

Cytoskeletal mechanisms regulating attaching/effacing bacteria interactions with host cells: It takes a village to build the pedestal

BioEssays, Volume 46, Issue 11, November 2024.
Attaching/effacing pathogens, such as enteropathogenic and enterohemorrhagic Escherichia coli, colonize host cells by triggering the assembly of actin filament‐rich pedestals beneath bacterial attachment sites. In this review we discuss the roles of different host actin‐binding and motor proteins in regulating pedestal assembly and bacterial ...
Nayden G. Naydenov, Armando Marino‐Melendez, Kenneth G. Campellone, Andrei I. Ivanov   +3 more
wiley   +1 more source

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase

Blood, 2005
Translocations of the anaplastic lymphoma kinase (ALK) gene have been described in anaplastic large-cell lymphomas (ALCLs) and in stromal tumors. The most frequent translocation, t(2;5), generates the fusion protein nucleophosmin (NPM)–ALK with intrinsic tyrosine kinase activity.
AMBROGIO, CHIARA, VOENA, claudia, MANAZZA AD, PIVA, Roberto, RIERA, Ludovica, BARBERIS, Laura, COSTA, Carlotta, TARONE, Guido, DEFILIPPI, Paola, HIRSCH, Emilio, ERBA EB, MOHAMMED S, JENSEN ON, PALESTRO, Giorgio, INGHIRAMI, Giorgio, CHIARLE, Roberto   +15 more
openaire   +6 more sources

Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs

FEBS Letters, Volume 598, Issue 15, Page 1811-1838, August 2024.
This Review presents the main advances in the study of PTP1B since it was first isolated, and recent contextual information related to this protein. Furthermore, we provide an overview of the role of PTP1B in diabetes and obesity, and the challenges of developing selective, effective, potent, bioavailable, and cell‐permeable compounds that can inhibit ...
Andrea Coronell‐Tovar, Juan P. Pardo, Adela Rodríguez‐Romero, Alejandro Sosa‐Peinado, Luz Vásquez‐Bochm, Patricia Cano‐Sánchez, Laura Iliana Álvarez‐Añorve, Martin González‐Andrade   +7 more
wiley   +1 more source

N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals

Nature Communications, 2019
O-glycosylation of neuropilin-1 is involved in cancer migration and invasion. Here, the authors show that defects in N-glycosylation of two neuropilin-1 splice variants enhance the co-internalisation of Met, it’s interaction with β1-integrin, and ...
Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y. Zaytseva, Kathleen L. O’Connor, Craig W. Vander Kooi, Side Liu, Qing-Bai She   +10 more
doaj   +1 more source

c-Src signaling in triple negative breast cancer cells: role of Cyr61 [PDF]

, 2016
Póster presentado al CNIO Frontiers Meeting: "Metastasis Initiation: Mechanistic Insights and Therapeutic Opportunities", celebrado en el Spanish National Cancer Research Centre (CNIO) Auditorium del 28 al 30 de septiembre de 2015.The SFKs (Src Family ...
Calcabrini, Annarica, Martín-Pérez, Jorge, Mayoral-Varo, Víctor, Pérez-Losada, J., Sánchez-Bailón, María Pilar   +4 more
core  

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation [PDF]

, 2014
The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that
A Banno, A Carisey, A Del Rio, A Kishino, AD Bershadsky, AR Gingras, BD Hoffman, BT Goult, BT Goult, C Ciobanasu, C Grashoff, E Goksoy, F Margadant, GCK Roberts, H Chen, H Chen, H Chen, H Fu, H Hirata, H-S Lee, H-S Lee, J Han, JD Humphries, NJ Anthis, PR Elliott, PRJ Bois, PRJ Bois, SE Lee, SJ Ellis, T Wieprecht, TJ Proszynski, V Vogel, Y Gao, Y Sawada, Y Sawada   +34 more
core   +2 more sources

Chemogenetic Tools in Focus: Proximity, Conformation, and Sterics

Chemistry–Methods, Volume 4, Issue 6, June 2024.
Chemogenetic tools have been widely applied to interrogate dynamic biological processes. They are genetically encoded systems that are controlled by user‐defined chemicals. In this review, chemogenetic tool designs for various biological applications are introduced and discussed.
Jiaqi Shen, Guanwei Zhou, Wenjing Wang
wiley   +1 more source