Results 101 to 110 of about 7,902 (230)
T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse [PDF]
, 2012 The role of non-muscle myosin IIA (heavy chain encoded by the non-muscle myosin heavy chain 9 gene, Myh9) in immunological synapse formation is controversial. We have addressed the role of myosin IIA heavy chain protein (MYH9) in mouse T cells responding
Luis Santos +6 more
core +2 more sources
CRKL but not CRKII contributes to hemin‐induced erythroid differentiation of CML
Journal of Cellular and Molecular Medicine, Volume 28, Issue 9, May 2024.Abstract Destruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR‐429‐CT10 regulation of kinase‐like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR‐429‐CRKL axis in leukaemic cell differentiation are still unknown.
Chunmei Guo +9 more
wiley +1 more source
Advanced Science, Volume 11, Issue 14, April 10, 2024.Cell migration is a dynamic cellular response determined by the molecular interaction between integrin and its partner ligands. To regulate the integrin‐mediated signaling, molecular tension probes that control the mechanical tolerance at the integrin‐ligand binding are introduced. This study reveals that manipulation of cell‐ECM adhesion strength at a
Seong‐Beom Han +6 more
wiley +1 more source
Self-organization of intrinsically disordered proteins with folded N-termini [PDF]
, 2010 Thousands of human proteins lack recognizable tertiary structure in most of their chains. Here we hypothesize that some use their structured N-terminal domains (SNTDs) to organise the remaining protein chain via intramolecular interactions, generating ...
Fred Schaper +4 more
core +1 more source
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology [PDF]
, 2017 A recent genome-wide association meta-analysis for Alzheimer's disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown.
A Bretteville +59 more
core +2 more sources
Biology Open, 2016 Cell migration is a highly dynamic process that plays pivotal roles in both physiological and pathological processes. We have previously reported that p130Cas supports cell migration through the binding to Src as well as phosphorylation-dependent ...
Zhihai Zhao +6 more
doaj +1 more source
Yersinia type III secretion : send in the effectors [PDF]
, 2002 Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block ...
Cornelis, G. R.
core +1 more source
A Hierarchical Mechanotransduction System: From Macro to Micro
Advanced Science, Volume 11, Issue 11, March 20, 2024.Mechanotransduction is a process of translating mechanical stimuli into biochemical signals and performs important regulatory functions at multiple levels, from molecules, subcellular structures, cells, tissues/organs, to whole‐body level. This review summarizes the physio‐pathological roles and mechanisms of mechanotransduction from macro to micro ...
Rong Cao +3 more
wiley +1 more source
Force-induced recruitment of cten along keratin network in epithelial cells. [PDF]
, 2019 The cytoskeleton provides structural integrity to cells and serves as a key component in mechanotransduction. Tensins are thought to provide a force-bearing linkage between integrins and the actin cytoskeleton; yet, direct evidence of tensin's role in ...
Cheah, Joleen S +4 more
core
Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract [PDF]
, 2021 Marwa Mahmoud +8 more
openalex +1 more source