Results 131 to 140 of about 89,060 (300)

A Survival Epidemiology Framework for Oral and Oropharyngeal Cancer

Cancer Nexus, EarlyView.
ABSTRACT Oral and oropharyngeal cancer remains a major global public health burden, but the literature addressing this disease is still organized predominantly around who develops it rather than around what determines life after diagnosis. That imbalance is consequential because diagnosis initiates a new scientific problem.
Raphael E. Cuomo
wiley   +1 more source

MultNAT HPV16/18 Assay: A Simple, Rapid, and Low‐Cost Polymerase Chain Reaction Method for the Detection of HPV16 and HPV18 Suitable for Point‐of‐Care Testing

Cancer Nexus, EarlyView.
ABSTRACT Aim Persistent high‐risk HPV infection can lead to the development of precancerous lesions, potentially progressing to invasive cancer. HPV status serves not only as a prognostic marker for squamous cell carcinoma (HNSCC) like oropharyngeal squamous cell carcinomas (OPSCC) but also significantly influences clinical management and treatment ...
Min Wang, Yueping Li, Qingting Bu, Peng Xiong, Suhang Li, Xiaoyan Li, Sisi Chen, Yanqiong Zhou, Siyu Li, Xiaojuan Jia   +9 more
wiley   +1 more source

Prognostic analysis of inconsistent combinations of HPV and p16 in a Chinese/Asian oropharyngeal squamous cell carcinoma population

Infectious Agents and Cancer
Background The aim of this study was to investigate the effect of inconsistent expression of p16 and HPV on the prognosis of patients with Oropharyngeal squamous cell carcinoma (OPSCC) in Chinese/Asian populations. Methods The study included 130 patients.
Jieying Li, Kai Zhou, Xiaohong Zhan, Haijun Lu, Dapeng Hao, Kai Song, Shuangyi Wang, Yuanyong Feng, Haoyue Xu, Zongxuan He, Xiaochen Yang, Wei Shang, Lin Wang   +12 more
doaj   +1 more source

Heterogeneity in studies of p16 in cervical lesions in different malaysian institutions: Time to consider collaborative study

, 2018
Introduction: Clinical decision making becomes difficult when clinical and methodological heterogeneity does not permit synthesis of results of multiple small studies.
Tan, Geok Chin, Subramaniam, Manimalar Selvi Naicker   +1 more
core  

Histological findings and expression patterns of p16.

, 2014
A: The squamous cell carcinoma components are located beneath the urothelial lining. The tumor cells are strongly positive for p16 (x100). B: This case is a mixed papillary urothelial carcinoma (left upper) and squamous cell carcinoma.
Weon Seo Park (543636), Kang Hyun Lee (543637), Sung Han Kim (512136), Jae Young Joung (543634), Jinsoo Chung (543635), Ho Kyung Seo (543638)   +5 more
core   +1 more source

Developing Sustainable Innovations for Planet, Profits—And People: Mixed‐Methods Insights From the Textile Industry

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Sustainable innovations are increasingly recognized as promising avenues for businesses to tackle global sustainability challenges, expected to deliver ecological, social, and economic benefits. Yet social outcomes at the individual level remain underexplored, raising questions about whether such innovations fully realize their sustainability ...
Lisa Hollands, Celine Bökemeyer, Luca Haensse, Nick Lin‐Hi   +3 more
wiley   +1 more source

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

Performance analysis of Leica Biosystems p16 monoclonal antibody in oropharyngeal squamous cell carcinoma

Diagnostic Pathology
Background Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death globally, with newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) cases rising to 54,000 in the US alone in the year 2022.
Selvam Thavaraj, Max Robinson, Shubham Dayal, Claire Bowen   +3 more
doaj   +1 more source

CDKN2A/p16 is inactivated in most melanoma cell lines

, 1997
The CDKN2A gene maps to chromosome 9p21-22 and is responsible for melanoma susceptibility in some families. Its product, p16, binds specifically to CDK4 and CDK6 in vitro and in vivo, inhibiting their kinase activity.
Castellano, Marina, Pollock, Pamela M., Sparrow, Louise E., Gabrielli, Brian G., Parsons, Peter G., Walters, Marilyn K., Down, Louise M., Hayward, Nicholas K.   +7 more
core  

Genetic detection of bladder cancer by microsatellite analysis of p16, RB1 and p53 tumor suppressor genes

, 2001
Purpose: We investigated the incidence of genetic alterations in urine specimens from patients with bladder cancer. Materials and Methods: A total of 28 cytological urine specimens were assessed for microsatellite alternations, and 15 microsatellite ...
Kazanis, I., Sourvinos, G., Cranidis, A., Delakas, D., Spandidos, D.A.   +4 more
core   +1 more source