Results 141 to 150 of about 89,060 (300)
Epilepsia Open, EarlyView.Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman +5 more
wiley +1 more source
p16: cycling off the beaten path
, 2019 p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-
Raquel Buj, Katherine M. Aird
core +1 more source
Fire and Rescue Service Preparedness for Natural Hazards
Fire and Materials, EarlyView.ABSTRACT Natural hazards driven by extreme weather events are expected to continue to pose a significant risk to citizens, property and the environment. Based on a series of national and international interviews with the Fire and Rescue Service (FRS), this paper presents an analysis of present practices within the FRS and FRS willingness to employ a ...
Johan Björck, Margaret McNamee
wiley +1 more source
Deceptive Thyroid Pathologies: Anaplastic Thyroid Carcinoma Mimics and Clinical Implications
Head &Neck, EarlyView.ABSTRACT Background Beyond follicular‐derived thyroid carcinomas, lymphomas, and metastatic disease, there are rare pathologies of the thyroid gland that represent a challenge. We report patients with unusual malignancies that mimic similar aggressive cancers. Methods Retrospective case series.
David Z. Allen +12 more
wiley +1 more source
Human Vaccines & ImmunotherapeuticsOral human papillomavirus (HPV) infection is a risk for oropharyngeal cancer (OPC), now the leading HPV-related cancer in males in Canada. P16 positivity is a marker of HPV positivity.
Voica Racovitan +5 more
doaj +1 more source
, 2018 Background:Oropharyngeal squamous cell carcinoma is thought to rarely metastasise to bone. This study hypothesised that in p16-positive disease there is a significant incidence of bony metastasis.Methods:This was an ambispective cohort review.
C D Passant, R G Thomas, A S Harris
core +1 more source
Head &Neck, EarlyView.ABSTRACT Background Oropharyngeal cancer (OPC) exhibits distinct clinical behaviors according to HPV/p16 status and smoking exposure. While HPV‐positive OPC generally shows superior survival, differences in recurrence patterns remain unclear. Methods A retrospective multicenter analysis of 674 AJCC VII edition Stage III–IVa/b OPC patients treated with ...
Riccardo Gili +16 more
wiley +1 more source
p16-induced apoptosis in Ewing\u27s sarcoma
, 2005 The tumor suppressor p16 is a negative regulator of the cell cycle, and acts by preventing the phosphorylation of RB, which in turn prevents the progression from G1 to S phase of the cell cycle.
Kannan, Geoffrey Sumithran
core
Disease Site‐Specific Outcomes in p16‐Positive Non‐Oropharyngeal Mucosal Head and Neck Cancer
Head &Neck, EarlyView.ABSTRACT Objectives To report disease‐free survival (DFS) in p16‐positive non‐oropharyngeal head‐and‐neck squamous‐cell carcinoma (HNSCC). Methods Curatively‐treated non‐oropharyngeal HNSCC (2009–2021) were reviewed. DFS was compared among p16‐positive, p16‐negative, and p16‐untested cases for the overall cohort and by disease site.
Revadhi C. Chelvarajah +21 more
wiley +1 more source
Head &Neck, EarlyView.ABSTRACT Background Patients with HPV+ oropharyngeal cancer (OPC) have worse outcomes with longer smoking history (≥ 10 pack‐years). This has been confirmed in trials of primary radiotherapy but not surgery, suggesting differential smoking impact by treatment received. We assessed smoking‐related outcomes at a single institution.
Michelle M. Kwan +17 more
wiley +1 more source