Results 161 to 170 of about 89,060 (300)

Robotic‐Assisted Extended Sistrunk Approach (RESA) for Salvage Surgery After Head and Neck Irradiation

open access: yesHead &Neck, EarlyView.
ABSTRACT Background The robotic‐assisted extended “Sistrunk” approach (RESA) is a minimally invasive technique providing access to hypopharyngeal and laryngeal structures via a submental incision and vallecular pharyngotomy, bypassing the base of tongue.
Bartosz Wojtera   +5 more
wiley   +1 more source

Non‐Metastatic Squamous Cell Carcinoma of the Oropharynx: Primary Surgery or (Chemo)radiotherapy?

open access: yesHead &Neck, EarlyView.
ABSTRACT Background In patients with locally advanced, non‐metastatic oropharyngeal squamous cell carcinoma (OPSCC), surgery‐based and nonsurgical treatment approaches have not been adequately compared in randomized Phase III clinical trials. Current clinical guidelines recommend various surgical and nonsurgical strategies across disease stages for ...
Primož Strojan   +12 more
wiley   +1 more source

The new meaning of retirement for bridge employees: Situating bridge employment through the lens of the Kaleidoscope Career Model

open access: yesHuman Resource Development Quarterly, Volume 36, Issue 1, Page 89-112, Spring 2025.
Abstract Retirees re‐entering the workforce, popularly termed as bridge employment, is a phenomenon that is anticipated to increase in the coming years. Though research establishes that these employees have unique aspirations and work motives (see Mazumdar et al., 2020), primary research on how the retirement transition and bridge employment shape each
Bishakha Mazumdar   +2 more
wiley   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin   +9 more
wiley   +1 more source

Clinical Validation of Four Point‐of‐Care High‐Risk HPV Assays, Including Two Reduced‐Valency Assays, for Cervical Cancer Screening in Low‐Resource Settings

open access: yesInternational Journal of Cancer, EarlyView.
High‐risk human papillomavirus (hrHPV) testing improves cervical cancer screening by facilitating earlier detection and prevention. In low‐resource settings, however, cost and increased referrals limit its use. At the same time, many new and more affordable assays lack validation.
Neerja Bhatla   +28 more
wiley   +1 more source

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

open access: yesiMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin   +13 more
wiley   +1 more source

Targeting the senescence‒autophagy axis via p16<sup>INK4a</sup> inhibition alleviates pulmonary fibrosis. [PDF]

open access: yesSignal Transduct Target Ther
Yoo YJ   +16 more
europepmc   +1 more source

Advances in Fluorescent Probes Targeting Senescence‐Associated β‐Galactosidase for Senescence Imaging

open access: yesiRADIOLOGY, EarlyView.
Senescence‐associated β‐galactosidase fluorescent probes enable sensitive visualization of cellular senescence through turn‐on, ratiometric, aggregation‐induced emission‐active, and nanoprobe strategies. ABSTRACT Aging is a systemic biological process that spans multiple levels, including molecules, cells, tissues, and organs.
Jiahui Wang   +5 more
wiley   +1 more source

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