Results 71 to 80 of about 208,852 (280)
Integrative Approaches to Treating Cellular Senescence in Kidney Disease
Advanced Science, EarlyView.ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa +3 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2006 p16INK4a is a major tumor-suppressor protein, but its regulation and settings of fuction remain poorly understood. To explore the notion that p16 is induced in vivo in response to replicative stress, we examined p16 expression in tissues from human ...
Emma E. Furth +7 more
doaj +1 more source
A multiwavelength view of BL Lacs neutrino candidates [PDF]
, 2018 The discovery of high-energy astrophysical neutrinos by IceCube kicked off a new line of research to identify the electromagnetic counterparts producing these neutrinos.
Pacciani, L., Righi, C., Tavecchio, F.
core +2 more sources
Hypermethylation of the p16 Gene and Lack of p16 Expression in Hepatoblastoma [PDF]
Modern Pathology, 2003 Hepatoblastoma is the most frequent pediatric liver tumor that develops mostly in young children. Abnormal regulation of cell cycle regulatory genes including p16 has been described, displaying no p16 mRNA and p16 protein in hepatoblastomas. The inactivation of p16, leading to the disruption of cell cycle control is involved in many types of human ...
Yhong-Hee, Shim +7 more
openaire +2 more sources
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
Chinese Medical Journal. Background:. P16 inactivation is frequently accompanied by telomerase reverse transcriptase (TERT) amplification in human cancer genomes. P16 inactivation by DNA methylation often occurs automatically during immortalization of normal cells by TERT ...
Xuehong Zhang +10 more
doaj +1 more source
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels
Frontiers in Cell and Developmental Biology, 2020 The lipid-storage hepatic stellate cells (HSC) play as pivotal role in liver fibrosis being able to trans-differentiate into myofibroblasts in response to various pro-fibrogenic stimuli.
Fangqiao Lv +9 more
doaj +1 more source
The sustainable growth of the first black holes [PDF]
, 2017 Super-Eddington accretion has been suggested as a possible formation pathway of $10^9 \, M_\odot$ supermassive black holes (SMBHs) 800 Myr after the Big Bang.
Pezzulli, Edwige +3 more
core +3 more sources
Correlation of p16 Hypermethylation with p16 Protein Loss in Sporadic Gastric Carcinomas [PDF]
Laboratory Investigation, 2000 Hypermethylation of p16 has been detected frequently in a variety of cancer cells and is known to repress the level of p16 transcription. In human gastric carcinoma (GC) cells, p16 protein loss has often been detected, but genetic alterations of p16 are infrequent.
Y H, Shim, G H, Kang, J Y, Ro
openaire +2 more sources
Advanced Science, EarlyView.A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang +11 more
wiley +1 more source