Results 101 to 110 of about 217,248 (344)

Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis [PDF]

, 2016
Dedifferentiated chondrosarcoma (DDCS) is a rare disease with a dismal prognosis. DDCS consists of two morphologically distinct components: the cartilaginous and noncartilaginous components.
Cao, Dengfeng, Chen, Rongrong, Chen, Xi, DeLaney, Thomas F, Gao, Lu, Gao, Xiaohuan, Gong, Xinqi, Guo, Xiaopeng, Hong, Xiafei, Ni, Jianjiao, Tian, Pangzehuan, Wang, Renzhi, Xing, Bing, Yao, Yong   +13 more
core   +2 more sources

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Multivalent display of VP28 on chimeric virus-like particles enhances binding to shrimp target tissues: A novel antiviral strategy against white spot syndrome virus [PDF]

Veterinary World
Background and Aim: White spot syndrome virus (WSSV) is a devastating pathogen in shrimp aquaculture, with viral protein 28 (VP28) playing a critical role in host cell attachment and entry. The extracellular domain of VP28 (residues 35–95) is immunogenic
Somkid Jaranathummakul, Pitchanee Jariyapong, Orawan Thongsum, Supawich Boonkua, Charoonroj Chotwiwatthanakun, Monsicha Somrit, Somluk Asuvapongpatana, Attaboon Wathammawut, Wattana Weerachatyanukul   +8 more
doaj   +1 more source

Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features

Advanced Healthcare Materials, EarlyView.
This study characterizes the presence of microplastics in human normal gastric, para‐tumor, and gastric tumor tissue and confirms the association between microplastic exposure and lymph node metastasis in gastric cancer. This study explores the transcriptomic changes induced by microplastic exposure, laying the foundation for further investigation into
Liqiao Chen, Jialin Li, Yan Wu, Han Bao, Xuesong Yang, Guoqing Lv, Ke Ji, Ji Zhang, Xiaojiang Wu, Kai Zhou, Jieli Xu, Jiatian Tang, Xiyuan Han, Anqiang Wang   +13 more
wiley   +1 more source

Complexity and diversity of the NKR-P1:Clr (Klrb1:Clec2) recognition systems

Frontiers in Immunology, 2014
The NKR-P1 receptors were identified as prototypical natural killer (NK) cell surface antigens and later shown to be conserved from rodents to humans on NK cells and subsets of T cells.
Christina L Kirkham, James R Carlyle
doaj   +1 more source

Start, Stop, Rewind, Repeat—Cyclic Exposure of Adipose Stromal Cells‐derived Cartilage Organoids to Chondrogenic and Proliferative Cues to Achieve Scaled‐up and Customizable Bone Formation by Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
This study exploits the plasticity of ASCs‐derived cartilage organoids which generate a perichondrial layer of MSCs when exposed to cyclic chondrogenic/proliferative cues. Using these organoids as building blocks, we develop (i) Phalange Shaped Tissue Engineered Cartilage (Pa‐TECs), recapitulating endochondral ossification suitable for the treatment of
Pablo Pfister, Emilien Lhospice, Andrés García‐García, Robert Paillaud, Sebastian Jung, Romain Schaller, Elisabeth A. Kappos, Claude Jaquiéry, Tarek Ismail, Dirk J. Schaefer, Michael de Wild, Ivan Martin, Alexandre Kaempfen, Arnaud Scherberich, Adrien Moya   +14 more
wiley   +1 more source

Vertical Self‐Rectifying Memristive Arrays for Page‐Wise Parallel Logic and Arithmetic Processing

Advanced Materials, EarlyView.
This study proposes a page‐wise logic‐in‐memory architecture realized in a 3D vertical resistvie random‐access memory array of self‐rectifying memristors. By introducing intra‐ and inter‐page logic primitives, the system enables Boolean and arithmetic operations to be executed directly within the memory.
Kunhee Son, Jea Min Cho, Dong Hoon Shin, Yeong Rok Kim, Néstor Ghenzi, Sunwoo Cheong, Byeong Su Kim, Jung Kyu Lee, Sungho Kim, Wonho Choi, Soo Hyung Lee, Janguk Han, Cheol Seong Hwang   +12 more
wiley   +1 more source

Trends in Presentation, Management, and Survival of Women With Breast Cancer in a Multiethnic, Middle-Income Asian Setting

JCO Global Oncology
PURPOSEGranular data on breast cancer (BC) are pertinent for surveillance, planning, and monitoring of cancer care delivery. We determined the trends in clinical presentation, management, and survival of women with BC in a multiethnic middle-income Asian
Sharminii Jaya-Prakason, Yek-Ching Kong, Cheng-Har Yip, Mee-Hoong See, Nur Aishah Taib, Nur Fadhlina Abdul Satar, Suniza Jamaris, Li Ying Teoh, Rose Irnawaty Ibrahim, Nirmala Bhoo-Pathy   +9 more
doaj   +1 more source

Electrically Assisted Thermal Stamping of Tunable Carbon‐Based Nanofilms for Direct Fabrication of Hydrophobic, Energy Harvesting, and Sensing Devices

Advanced Materials, EarlyView.
Schematic illustration of the electrically assisted thermal stamping (EATS) method for direct fabrication of carbon‐based nanofilms and their multifunctional applications. Localized Joule heating triggers simultaneous exfoliation, reduction, and fluoropolymer incorporation under ambient conditions, yielding tunable carbon‐based thin‐film coatings ...
Byungseok Seo, Yong Choi, Gajendra S. Shekhawat, Minjoong Shin, Kunmo Koo, Xiaobing Hu, Jiheon Kim, Wonjoon Choi, Xinqi Chen, Vinayak P. Dravid   +9 more
wiley   +1 more source

Frequencies of interleukin-6, GST and progesterone receptor gene polymorphisms in postmenopausal women with low bone mineral density

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Osteoporosis is a skeletal disorder characterized by low bone mineral density (BMD). Studies have shown that some of the genetic components relating to lower BMD may be detected by polymorphisms.
Katia Franco Moura, Mauro Haidar, Claudio Bonduki, Paulo Cezar Feldner Junior, Ismael Silva, Jose Maria Soares Junior, Manoel Joao Girao   +6 more
doaj   +1 more source