Results 81 to 90 of about 99,821 (298)

Topography‐Regulated Screening Platform for Myoblast Contact Guidance

Advanced Materials Technologies, EarlyView.
This study develops a topography‐regulated screening platform (12 gradients in 96‐topography‐well plate) enabling analysis of skeletal muscle morphogenesis. The topography‐induced cell morphology changed, cell polarization, and myotube differentiation, establishing an evaluative framework for generating pathologically relevant myotube phenotypes to ...
Tianqi Feng, Torben A.B. van der Boon, Savannah Amy Haupt, Adam Jones, Yanjing Ji, Theo G. Van Kooten, Patrick van Rijn   +6 more
wiley   +1 more source

DNA methylation promotes the expression of PPARγ transcript 1 at least in part by preventing NRF1 binding to the promoter P1 of chicken PPARγ gene

Poultry Science
: Peroxisome proliferator-activated receptor gamma (PPARγ) is a master regulator of adipogenesis. Our previous study revealed that chicken PPARγ has 3 alternative promoters named as P1, P2, and P3, and the DNA methylation of promoter P3 was negatively ...
T.T. Cui, J.X. Huang, B.L. Ning, F. Mu, H.Y. Chen, T.Y. Xing, H. Li, N. Wang   +7 more
doaj   +1 more source

Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin. [PDF]

PLoS ONE, 2013
The genes encoding nuclear receptors comprise multiple 5'untranslated exons, which give rise to several transcripts encoding the same protein, allowing tissue-specific regulation of expression.
Emma S Garratt, Mark H Vickers, Peter D Gluckman, Mark A Hanson, Graham C Burdge, Karen A Lillycrop   +5 more
doaj   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Insulin-like growth factor-1 stimulates proliferation of myeloid FDC-P1 cells overexpressing the human colony-stimulating factor-1 receptor.

, 1992
Retrovirally expressed human CSF-1 receptor can induce CSF-1-dependent growth of IL-3-dependent hemopoietic cells FDC-P1. Here we show that expression of the human CSF-1 receptor also allowed FDC-P1 cells to grow in response to Insulin-like Growth Factor-
Ballmer-Hofer, K., Morlé, F., Blanchet, J. P., von Rüden, T., Mouchiroud, G., Bourette, R. P.   +5 more
core   +1 more source

Scavenger receptor CL-P1 mediates endocytosis by associating with AP-2μ2

Biochimica et Biophysica Acta (BBA) - General Subjects, 2014
Scavenger receptor CL-P1 (collectin placenta 1) has been found recently as a first membrane-type collectin which is mainly expressed in vascular endothelial cells. CL-P1 can endocytose OxLDL as well as microbes but in general, the endocytosis mechanism of a scavenger receptor is not well elucidated.We screened a placental cDNA library using a yeast two-
SeongJae, Jang, Ohtani, Katsuki, Fukuoh, Atsushi, Mori, Kenichiro, Yoshizaki, Takayuki, Kitamoto, Noritoshi, YounUck, Kim, Suzuki, Yasuhiko, Wakamiya, Nobutaka   +8 more
openaire   +3 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Receptor-mediated inositol phosphate metabolism in rat cerebral cortical slices.

, 1987
Receptor-mediated phosphoinositide hydrolysis was studied in 3H-myo-inositol labelled rat cerebral cortical slices. Several CNS neurotransmitter receptor agonists stimulated the hydrolysis of inositol phospholipid(s).
Ian Batty (7700339)
core  

Blue Mussel-Derived Bioactive Peptides PIISVYWK (P1) and FSVVPSPK (P2): Promising Agents for Inhibiting Foam Cell Formation and Inflammation in Cardiovascular Diseases

Marine Drugs
Atherosclerosis is a key etiological event in the development of cardiovascular diseases (CVDs), strongly linked to the formation of foam cells. This study explored the effects of two blue mussel-derived bioactive peptides (BAPs), PIISVYWK (P1) and ...
Chathuri Kaushalya Marasinghe, Jae-Young Je   +1 more
doaj   +1 more source

Prior Expectations Bias Confidence Judgments Through Parietal Alpha‐Band Modulation

Advanced Science, EarlyView.
ABSTRACT Humans possess the metacognitive ability to estimate the likely accuracy of their own decisions through confidence judgments. Yet, whether prior information shapes confidence and the neural mechanisms mediating such influence, remain to be determined.
Luca Tarasi, Anna Pasini, Domenico Romanazzi, Margherita Covelli, Vincenzo Romei   +4 more
wiley   +1 more source