Results 91 to 100 of about 1,469,677 (296)

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Histology and matched multi-omics profiling resolve developmental transitions in Wugang Copper Goose leg muscle

Poultry Science
Wugang Copper Goose is an indigenous meat-type breed, but the molecular events accompanying leg muscle development around hatch remain unclear. We examined breast and leg muscle histology at embryonic days 15 (E15), 19 (E19), 23 (E23), and 28 (E28) and ...
Xu He, Weican Wan, Chuze Gao, Xianxin Zhang, Bocheng Liu, Yu Tan, Guitao Jiang   +6 more
doaj   +1 more source

Basic biology of tendon injury and healing.

, 2005
Tendon disorders are commonly seen in clinical practice. Their successful treatment is difficult and patients often experience symptoms for prolonged periods of time.
MAFFULLI, Nicola, Sharma P1
core  

Autoinactivation of the Stargazin–AMPA Receptor Complex: Subunit-Dependency and Independence from Physical Dissociation [PDF]

, 2012
are modulated by transmembrane accessory proteins. Stargazin, the prototypical accessory protein, decreases desensitization and increases agonist potency at AMPA receptors.
Sarah K Coleman, Esa R. Korpi (121902), Kari Keinänen (121905), Esa R Korpi, Coleman, Sarah Kate, Kari Keinänen, Keinänen, Kari, Artur Semenov (121893), Tommi Möykkynen, Tommi Möykkynen (121896), Artur Semenov, Semenov, Artur, Korpi, Esa Risto, Möykkynen, Tommi Petteri, Sarah K. Coleman (121899)   +14 more
core   +2 more sources

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Production of a soluble form of the human NK cell receptor NKR-P1 and its ligand LLT1 [PDF]

Tato bakalářská práce se zaměřuje na přípravu rozpustné formy receptoru NKR-P1 (receptor lidských přirozeně zabíječských buněk) a jeho ligandu LLT1.
Maksimova, Anna Dmytrivna
core   +1 more source

Multivalent display of VP28 on chimeric virus-like particles enhances binding to shrimp target tissues: A novel antiviral strategy against white spot syndrome virus [PDF]

Veterinary World
Background and Aim: White spot syndrome virus (WSSV) is a devastating pathogen in shrimp aquaculture, with viral protein 28 (VP28) playing a critical role in host cell attachment and entry. The extracellular domain of VP28 (residues 35–95) is immunogenic
Somkid Jaranathummakul, Pitchanee Jariyapong, Orawan Thongsum, Supawich Boonkua, Charoonroj Chotwiwatthanakun, Monsicha Somrit, Somluk Asuvapongpatana, Attaboon Wathammawut, Wattana Weerachatyanukul   +8 more
doaj   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Trends in Presentation, Management, and Survival of Women With Breast Cancer in a Multiethnic, Middle-Income Asian Setting

JCO Global Oncology
PURPOSEGranular data on breast cancer (BC) are pertinent for surveillance, planning, and monitoring of cancer care delivery. We determined the trends in clinical presentation, management, and survival of women with BC in a multiethnic middle-income Asian
Sharminii Jaya-Prakason, Yek-Ching Kong, Cheng-Har Yip, Mee-Hoong See, Nur Aishah Taib, Nur Fadhlina Abdul Satar, Suniza Jamaris, Li Ying Teoh, Rose Irnawaty Ibrahim, Nirmala Bhoo-Pathy   +9 more
doaj   +1 more source

An Olfactory Receptor Pseudogene whose Function emerged in Humans [PDF]

, 2007
Human olfactory receptor, hOR17-210, is identified as a pseudogene in the human genome. Experimental data has shown however, that the gene product of cloned hOR17-210 cDNA was able to bind an odorant-binding protein and is narrowly tuned for excitation ...
Gautam Bahl, Valery Matarazzo, Chiquito J. Crasto, Peter Lai, Olivier Clot-Faybesse, Catherine Ronin, Maryse Gremigni   +6 more
core   +1 more source