Results 31 to 40 of about 217,248 (344)

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

open access: yes, 2010
Peer reviewedPublisher ...
Barabas, Klaudia   +9 more
core   +1 more source

Expression and biological activity of two recombinant polypeptides related to subunit 1 of the interferon-a receptor

open access: yesBrazilian Journal of Medical and Biological Research, 2000
Abnormal production of interferon alpha (IFN-a) has been found in certain autoimmune diseases and can be also observed after prolonged therapy with IFN-a.
S. Yoon   +5 more
doaj   +1 more source

Purinergic Regulation of Food and Fat Intakes in Broiler’s Central Nervous System [PDF]

open access: yesIranian Journal of Veterinary Medicine, 2021
BACKGROUND: Adenosine has many physiological roles in the brain, and in rodents, it changes food intake when applied centrally. OBJECTIVES: We investigated the effect of central injection of the purine molecule adenosine on both food and fat intakes in ...
Sahel Motaghi   +3 more
doaj   +1 more source

Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway [PDF]

open access: yes, 1993
Molecular conjugate vectors may be constructed that accomplish high efficiency gene transfer by the receptor-mediated endocytosis pathway. In order to mediate escape from lysosomal degradation, we have incorporated adenoviruses into the functional design
Curiel, David T.   +5 more
core   +2 more sources

P1-508 Oestrogen receptor β expression in colorectal cancer [PDF]

open access: yesJournal of Epidemiology and Community Health, 2011
Introduction The oestrogen receptor β (ERβ) is the primarily expressed ER in the large intestine and has been found to have inhibitory effects on colon cancer cells. We therefore investigated, whether the ERβ expression in tumour tissue from colorectal cancer (CRC) patients is associated with tumour/clinical ...
A Rudolph   +7 more
openaire   +1 more source

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

open access: yesFrontiers in Cellular Neuroscience, 2019
Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory response, which comprises a rapid initial increase in breathing followed by a slower secondary ...
Robert J. Reklow   +13 more
doaj   +1 more source

Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate. [PDF]

open access: yesPLoS ONE, 2014
Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation. We recently reported that these compounds antagonize
Hung Chang   +8 more
doaj   +1 more source

Inhibition of avian influenza virus H9N2 infection by antiviral hexapeptides that target viral attachment to epithelial cells

open access: yesVirus Research, 2022
The H9N2 subtype of influenza A virus circulates frequently among poultry in Asian and North African countries causing economic loss in the poultry sector. The antigenic variations of the H9N2 virus were at the origin of its genetic evolution through the
Marwa Arbi   +7 more
doaj   +1 more source

The aberrant expression of the mesenchymal variant of FGFR2 in the epithelial context inhibits autophagy [PDF]

open access: yes, 2019
Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation ...
Belleudi, Francesca   +4 more
core   +1 more source

Purinergic Signalling: Therapeutic Developments

open access: yesFrontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj   +1 more source

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