Results 21 to 30 of about 117,126 (251)

Vimentin Is an Attachment Receptor for Mycoplasma pneumoniae P1 Protein

Microbiology Spectrum, 2023
Mycoplasma pneumoniae is the most common pathogen causing respiratory tract infection, and the P1 protein on its adhesion organelle plays a crucial role during the pathogenic process. A variety of experiments, including enzyme-linked immunosorbent assay (ELISA), coimmunoprecipitation, adhesion, and adhesion inhibition assay ...
Kailan Peng, Yating Liao, Xia Li, Dongdong Zeng, Youyuan Ye, Li Chen, Zhuo Zeng, Yanhua Zeng   +7 more
openaire   +2 more sources

Modelling and analysis of biochemical signalling pathway cross-talk [PDF]

, 2010
Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing ...
Emanuela Merelli, Muffy Calder, Paola Quaglia, Robin Donaldson   +3 more
core   +5 more sources

Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine

Communications Biology, 2023
Influenza virus poses an ongoing human health threat with pandemic potential. Due to mutations in circulating strains, formulating effective vaccines remains a challenge. The use of computationally optimized broadly reactive antigen (COBRA) hemagglutinin
John V. Dzimianski, Julianna Han, Giuseppe A. Sautto, Sara M. O’Rourke, Joseph M. Cruz, Spencer R. Pierce, Jeffrey W. Ecker, Michael A. Carlock, Kaito A. Nagashima, Jarrod J. Mousa, Ted M. Ross, Andrew B. Ward, Rebecca M. DuBois   +12 more
doaj   +1 more source

Hepatic and Extrahepatic Insulin Clearance in Mice with Double Deletion of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Receptors

Biomedicines, 2021
The aim of this study was to investigate whether incretins, at physiological levels, affect hepatic and/or extrahepatic insulin clearance. Hepatic and extrahepatic insulin clearance was studied in 31 double incretin receptor knockout (DIRKO) and 45 wild ...
Micaela Morettini, Agnese Piersanti, Laura Burattini, Giovanni Pacini, Christian Göbl, Bo Ahrén, Andrea Tura   +6 more
doaj   +1 more source

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival

Frontiers in Cellular Neuroscience, 2019
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin, Peter R. Thorne, Gary D. Housley, Srdjan M. Vlajkovic   +3 more
doaj   +1 more source

Axon regeneration after optic nerve injury in rats can be improved via PirB knockdown in the retina

Cell & Bioscience, 2021
Background In the central nervous system (CNS), three types of myelin-associated inhibitors (MAIs) exert major inhibitory effects on nerve regeneration: Nogo-A, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp).
Mei Yang, Lan Jian, Wei Fan, Xing Chen, Huan Zou, Yanming Huang, Xiaofan Chen, Yuan-Guo Zhou, Rongdi Yuan   +8 more
doaj   +1 more source

Differential spatial distribution of HNF4α isoforms during dysplastic progression of intraductal papillary mucinous neoplasms of the pancreas

Scientific Reports, 2023
Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions.
Jahg Wong, Vincent Q. Trinh, Nidhi Jyotsana, Jumanah F. Baig, Frank Revetta, Chanjuan Shi, Anna L. Means, Kathleen E. DelGiorno, Marcus Tan   +8 more
doaj   +1 more source

Bioengineering models of cell signaling [PDF]

, 2000
Strategies for rationally manipulating cell behavior in cell-based technologies and molecular therapeutics and understanding effects of environmental agents on physiological systems may be derived from a mechanistic understanding of underlying signaling ...
Asthagiri, Anand R., Lauffenburger, Douglas A.   +1 more
core   +1 more source

Expression and biological activity of two recombinant polypeptides related to subunit 1 of the interferon-a receptor

Brazilian Journal of Medical and Biological Research, 2000
Abnormal production of interferon alpha (IFN-a) has been found in certain autoimmune diseases and can be also observed after prolonged therapy with IFN-a.
S. Yoon, R.D.C. Hirata, N.Y. Nguyen, R. Curi, M. Russo, M.H. Hirata   +5 more
doaj   +1 more source

Adaptive Evolution of the Myo6 Gene in Old World Fruit Bats (Family: Pteropodidae) [PDF]

, 2013
PMCID: PMC3631194This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Nykjaer, A Nykjaer, AL Dance, AL Wells, B Shen, B Shen, B Uberti, Bin Shen, Brock Fenton, CC Voigt, D Biemesderfer, D Novick, D Posada, D Posada, D Shriner, DW Thomas, EC Teeling, EI Christensen, EM De La Cruz, ES Dierenfeld, F Buss, F Buss, F Buss, F Ronquist, G Gottsberger, G Jones, G Jones, G Li, Gareth Jones, GL Herrera, H Birn, H Raghuram, HL Sweeney, J Breckler, J Kitamoto, J Ménétrey, J van der Westhuyzen, J Vandesompele, J Zhang, JC Buckland-Wright, JD Thompson, K Homma, K Parry-Jones, K Takeyama, K Tamura, KB Avraham, KJ Livak, KT Davies, L Aschenbrenner, L Aschenbrenner, LH Herbst, M Cavaleros, MB Fenton, MC Wendeln, MLG Herrera, N Ameen, N Gotoh, N Hilgert, P Heidrych, PA Peterson, R Hertzano, R Kozyraki, RA Tedman, RD Barber, RMR Barclay, RS Heffner, RS Heffner, S Melchionda, SE Courts, Shuyi Zhang, SJ Rossiter, SK Moestrup, SL Kosakovsky Pond, SL Kosakovsky Pond, SL Pond, SL Pond, Stephen J. Rossiter, SV van Tonder, T Datzmann, T Hasson, T Self, X Zhou, Xiuqun Han, Y Li, Y Liu, Y Liu, Y Liu, Y Liu, Z Liu, Z Yang, ZM Ahmed, ZM Fuzessery   +91 more
core   +7 more sources