Results 21 to 30 of about 97,940 (264)
Axon regeneration after optic nerve injury in rats can be improved via PirB knockdown in the retina
Cell & Bioscience, 2021 Background In the central nervous system (CNS), three types of myelin-associated inhibitors (MAIs) exert major inhibitory effects on nerve regeneration: Nogo-A, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp).
Mei Yang +8 more
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Scientific Reports, 2023 Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions.
Jahg Wong +8 more
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Brazilian Journal of Medical and Biological Research, 2000 Abnormal production of interferon alpha (IFN-a) has been found in certain autoimmune diseases and can be also observed after prolonged therapy with IFN-a.
S. Yoon +5 more
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G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions [PDF]
Purinergic Signalling, 2012 The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors (ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and pyrimidine mono- and dinucleotides) has recently advanced significantly leading to selective ligands.
Kenneth A, Jacobson +3 more
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2019 Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory response, which comprises a rapid initial increase in breathing followed by a slower secondary ...
Robert J. Reklow +13 more
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Purinergic Regulation of Food and Fat Intakes in Broiler’s Central Nervous System [PDF]
Iranian Journal of Veterinary Medicine, 2021 BACKGROUND: Adenosine has many physiological roles in the brain, and in rodents, it changes food intake when applied centrally. OBJECTIVES: We investigated the effect of central injection of the purine molecule adenosine on both food and fat intakes in ...
Sahel Motaghi +3 more
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Frontiers in Physiology, 2018 Peroxisome proliferator-activated receptor-γ (PPARγ) is a master regulator of adipogenesis, and alterations in its function are associated with various pathological processes related to metabolic syndrome.
Tingting Cui +27 more
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Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate. [PDF]
PLoS ONE, 2014 Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation. We recently reported that these compounds antagonize
Hung Chang +8 more
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Towards a revised nomenclature for P1 and P2 receptors
Trends in Pharmacological Sciences, 1997 8
B. Fredholm +7 more
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Purinergic Signalling: Therapeutic Developments
Frontiers in Pharmacology, 2017 Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
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