Results 21 to 30 of about 1,469,677 (296)

Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse

Nature Communications, 2022
NKR-P1 is an inhibitory receptor on the surface of natural killer cells, and its engagement with the ligand LLT1 on activated monocytes and B cells triggers NK cell self-tolerance and other immunological processes.
Jan Bláha, Tereza Skálová, Barbora Kalousková, Ondřej Skořepa, Denis Cmunt, Valéria Grobárová, Samuel Pazicky, Edita Poláchová, Celeste Abreu, Jan Stránský, Tomáš Kovaľ, Jarmila Dušková, Yuguang Zhao, Karl Harlos, Jindřich Hašek, Jan Dohnálek, Ondřej Vaněk   +16 more
doaj   +1 more source

The Protective HIV-1 Envelope gp41 Antigen P1 Acts as a Mucosal Adjuvant Stimulating the Innate Immunity

Frontiers in Immunology, 2021
Mucosal nasal vaccine development, although ideal to protect from pathogens invading mucosally, is limited by the lack of specific adjuvant. We recently used P1, a conserved region of HIV-1 gp41-envelope glycoprotein, as efficient antigen in a ...
Lin Xu, Lin Xu, Lin Xu, Daniela Tudor, Daniela Tudor, Daniela Tudor, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +8 more
doaj   +1 more source

In silico identification and experimental validation of cellular uptake by a new cell penetrating peptide P1 derived from MARCKS

Drug Delivery, 2021
Viral vectors for vaccine delivery are challenged by recently reported safety issues like immunogenicity and risk for cancer development, and thus there is a growing need for the development of non-viral vectors.
Linlin Chen, Xiangli Guo, Lidan Wang, Jingping Geng, Jiao Wu, Bin Hu, Tao Wang, Jason Li, Changbai Liu, Hu Wang   +9 more
doaj   +1 more source

KLF2 Inhibits Chicken Preadipocyte Differentiation at Least in Part via Directly Repressing PPARγ Transcript Variant 1 Expression

Frontiers in Cell and Developmental Biology, 2021
Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulatory factor of preadipocyte differentiation. As a result of alternative splicing and alternative promoter usage, PPARγ gene generates multiple transcript variants encoding two ...
Tingting Cui, Tingting Cui, Tingting Cui, Tingting Cui, Jiaxin Huang, Jiaxin Huang, Jiaxin Huang, Yingning Sun, Yingning Sun, Yingning Sun, Yingning Sun, Bolin Ning, Bolin Ning, Bolin Ning, Fang Mu, Fang Mu, Fang Mu, Xin You, Xin You, Xin You, Yaqi Guo, Yaqi Guo, Yaqi Guo, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +28 more
doaj   +1 more source

Vimentin Is an Attachment Receptor for Mycoplasma pneumoniae P1 Protein

Microbiology Spectrum, 2023
Mycoplasma pneumoniae is the most common pathogen causing respiratory tract infection, and the P1 protein on its adhesion organelle plays a crucial role during the pathogenic process. A variety of experiments, including enzyme-linked immunosorbent assay (ELISA), coimmunoprecipitation, adhesion, and adhesion inhibition assay ...
Kailan Peng, Yating Liao, Xia Li, Dongdong Zeng, Youyuan Ye, Li Chen, Zhuo Zeng, Yanhua Zeng   +7 more
openaire   +2 more sources

A dual regulation mechanism of histidine kinase CheA identified by combining network-dynamics modeling and system-level input-output data. [PDF]

PLoS Computational Biology, 2018
It is challenging to decipher molecular mechanisms in biological systems from system-level input-output data, especially for complex processes that involve interactions among multiple components.
Bernardo A Mello, Wenlin Pan, Gerald L Hazelbauer, Yuhai Tu   +3 more
doaj   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases

Journal of Pharmacological Sciences, 2004
Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors.
Isao Matsuoka, Satoko Ohkubo
doaj   +1 more source

Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?

Cells, 2021
Alzheimer’s disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes,
Stefania Merighi, Tino Emanuele Poloni, Anna Terrazzan, Eva Moretti, Stefania Gessi, Davide Ferrari   +5 more
doaj   +1 more source

Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine

Communications Biology, 2023
Influenza virus poses an ongoing human health threat with pandemic potential. Due to mutations in circulating strains, formulating effective vaccines remains a challenge. The use of computationally optimized broadly reactive antigen (COBRA) hemagglutinin
John V. Dzimianski, Julianna Han, Giuseppe A. Sautto, Sara M. O’Rourke, Joseph M. Cruz, Spencer R. Pierce, Jeffrey W. Ecker, Michael A. Carlock, Kaito A. Nagashima, Jarrod J. Mousa, Ted M. Ross, Andrew B. Ward, Rebecca M. DuBois   +12 more
doaj   +1 more source

Hepatic and Extrahepatic Insulin Clearance in Mice with Double Deletion of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Receptors

Biomedicines, 2021
The aim of this study was to investigate whether incretins, at physiological levels, affect hepatic and/or extrahepatic insulin clearance. Hepatic and extrahepatic insulin clearance was studied in 31 double incretin receptor knockout (DIRKO) and 45 wild ...
Micaela Morettini, Agnese Piersanti, Laura Burattini, Giovanni Pacini, Christian Göbl, Bo Ahrén, Andrea Tura   +6 more
doaj   +1 more source