Results 11 to 20 of about 1,469,677 (296)

Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P1 [PDF]

open access: yesBiochimica et Biophysica Acta (BBA) - General Subjects, 2011
Scavenger receptors are generally expressed in macrophages and vascular endothelial cells and some scavenger receptors are thought to contribute to the development of atherosclerosis.We cloned the cDNA of a zebrafish CL-P1 (collectin placenta 1) and performed a knockdown study using its antisense morpholino oligonucleotides (MO).Zebrafish CL-P1 (zCL-P1)
Fukuda, Mitsuko   +9 more
core   +5 more sources

Molecular Characterisation of NKR-P1 receptor in peripheral blood of Pig [PDF]

open access: yesVeterinary World, 2008
Characterization of natural killer receptor-p1 (NKR-P1) in the leukocytes from peripheral blood of pig revealed three different clones of NKR-P1, 1,2 and 3. The RT-PCR product of human NKR-P1 gene was 573 base pair (bp).
Banshi Sharma   +2 more
doaj   +1 more source

Adenosine receptors as emerging therapeutic targets for diabetic kidney disease [PDF]

open access: yesKidney Research and Clinical Practice, 2022
Diabetic kidney disease (DKD) is now a pandemic worldwide, and novel therapeutic options are urgently required. Adenosine, an adenosine triphosphate metabolite, plays a role in kidney homeostasis through interacting with four types of adenosine receptors
Eun Seon Pak   +4 more
doaj   +1 more source

Receptor-mediated inositol phosphate metabolism in rat cerebral cortical slices.

open access: yes, 1987
Receptor-mediated phosphoinositide hydrolysis was studied in 3H-myo-inositol labelled rat cerebral cortical slices. Several CNS neurotransmitter receptor agonists stimulated the hydrolysis of inositol phospholipid(s).
Ian Batty (7700339)
core   +6 more sources

Effects of prolactin on movement disorders and APOE, GFAP, and PRL receptor gene expression following intracerebral hemorrhage in rats [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2021
Objective(s): Intracerebral hemorrhage (ICH) occurs mostly in the striatum. In ICH, blood prolactin level increases 3-fold. The effects of intracerebroventricular injection (ICV) of prolactin on motor disorders will be investigated. Materials and Methods:
Shiba Yousefvand   +6 more
doaj   +1 more source

Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts

open access: yesFrontiers in Endocrinology, 2023
Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors.
Hangxiu Che   +9 more
doaj   +1 more source

Systematic analyses of the sequence conservation and ligand interaction patterns of purinergic P1 and P2Y receptors provide a structural basis for receptor selectivity

open access: yesComputational and Structural Biotechnology Journal, 2023
Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides.
Ri Han   +3 more
doaj   +1 more source

Analysis of the HNF4A isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis

open access: yesCancer Biology & Medicine, 2021
Objective: Hepatocyte nuclear factor 4α (HNF4A) has been demonstrated to be an oncogene in gastric cancer (GC). However, the roles of different HNF4A isoforms derived from the 2 different promoters (P1 and P2) and the underlying mechanisms remain obscure.
Zhen Ni   +6 more
doaj   +1 more source

Targeting ErbB3 Receptor in Cancer with Inhibitory Antibodies from Llama

open access: yesBiomedicines, 2021
The human ErbB3 receptor confers resistance to the pharmacological inhibition of EGFR and HER2 receptor tyrosine kinases in cancer, which makes it an important therapeutic target.
Igor E. Eliseev   +9 more
doaj   +1 more source

P1 receptors and cytokine secretion [PDF]

open access: yesPurinergic Signalling, 2007
Evidence has accumulated in the last three decades to suggest tissue protection and regeneration by adenosine in multiple different cell types. Adenosine produced in hypoxic or inflamed environments reduces tissue injury and promotes repair by receptor-mediated mechanisms.
M.P. Abbracchio, S. Ceruti
openaire   +2 more sources

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