Results 31 to 40 of about 1,469,677 (296)

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival

open access: yesFrontiers in Cellular Neuroscience, 2019
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin   +3 more
doaj   +1 more source

Axon regeneration after optic nerve injury in rats can be improved via PirB knockdown in the retina

open access: yesCell & Bioscience, 2021
Background In the central nervous system (CNS), three types of myelin-associated inhibitors (MAIs) exert major inhibitory effects on nerve regeneration: Nogo-A, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp).
Mei Yang   +8 more
doaj   +1 more source

G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions [PDF]

open access: yesPurinergic Signalling, 2012
The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors (ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and pyrimidine mono- and dinucleotides) has recently advanced significantly leading to selective ligands.
Kenneth A, Jacobson   +3 more
openaire   +2 more sources

Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L [PDF]

open access: yes, 2014
Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures, which they themselves do not remain a part of.
Cato, L.   +7 more
core   +1 more source

Expression and biological activity of two recombinant polypeptides related to subunit 1 of the interferon-a receptor

open access: yesBrazilian Journal of Medical and Biological Research, 2000
Abnormal production of interferon alpha (IFN-a) has been found in certain autoimmune diseases and can be also observed after prolonged therapy with IFN-a.
S. Yoon   +5 more
doaj   +1 more source

Differential spatial distribution of HNF4α isoforms during dysplastic progression of intraductal papillary mucinous neoplasms of the pancreas

open access: yesScientific Reports, 2023
Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions.
Jahg Wong   +8 more
doaj   +1 more source

BACL is a novel brain-associated, non-NKC-encoded mammalian C-type lectin-like receptor of the CLEC2 family [PDF]

open access: yes, 2013
Natural Killer Gene Complex (NKC)–encoded C-type lectin-like receptors (CTLRs) are expressed on various immune cells including T cells, NK cells and myeloid cells and thereby contribute to the orchestration of cellular immune responses.
Mittelbronn, Michel Guy André   +11 more
core   +1 more source

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

open access: yesFrontiers in Cellular Neuroscience, 2019
Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory response, which comprises a rapid initial increase in breathing followed by a slower secondary ...
Robert J. Reklow   +13 more
doaj   +1 more source

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]

open access: yes, 2000
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
B. F. King   +17 more
core   +1 more source

Nuclear Respiratory Factor 1 Negatively Regulates the P1 Promoter of the Peroxisome Proliferator-Activated Receptor-γ Gene and Inhibits Chicken Adipogenesis

open access: yesFrontiers in Physiology, 2018
Peroxisome proliferator-activated receptor-γ (PPARγ) is a master regulator of adipogenesis, and alterations in its function are associated with various pathological processes related to metabolic syndrome.
Tingting Cui   +27 more
doaj   +1 more source

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