Results 31 to 40 of about 99,821 (298)

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]

, 2000
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
B. F. King, Burnstock, G., Wildman, Scott S.P., Townsend-Nicholson, A., Spyer, K. M., King, B F, A. Townsend-Nicholson, Thomas, T., G. Burnstock, Wildman, S. S., Thomas, T, King, B. F., Townsend-Nicholson, A, Burnstock, G, S. S. Wildman, Spyer, K M, T. Thomas, K. M. Spyer   +17 more
core   +1 more source

Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?

Cells, 2021
Alzheimer’s disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes,
Stefania Merighi, Tino Emanuele Poloni, Anna Terrazzan, Eva Moretti, Stefania Gessi, Davide Ferrari   +5 more
doaj   +1 more source

Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine

Communications Biology, 2023
Influenza virus poses an ongoing human health threat with pandemic potential. Due to mutations in circulating strains, formulating effective vaccines remains a challenge. The use of computationally optimized broadly reactive antigen (COBRA) hemagglutinin
John V. Dzimianski, Julianna Han, Giuseppe A. Sautto, Sara M. O’Rourke, Joseph M. Cruz, Spencer R. Pierce, Jeffrey W. Ecker, Michael A. Carlock, Kaito A. Nagashima, Jarrod J. Mousa, Ted M. Ross, Andrew B. Ward, Rebecca M. DuBois   +12 more
doaj   +1 more source

Hepatic and Extrahepatic Insulin Clearance in Mice with Double Deletion of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Receptors

Biomedicines, 2021
The aim of this study was to investigate whether incretins, at physiological levels, affect hepatic and/or extrahepatic insulin clearance. Hepatic and extrahepatic insulin clearance was studied in 31 double incretin receptor knockout (DIRKO) and 45 wild ...
Micaela Morettini, Agnese Piersanti, Laura Burattini, Giovanni Pacini, Christian Göbl, Bo Ahrén, Andrea Tura   +6 more
doaj   +1 more source

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival

Frontiers in Cellular Neuroscience, 2019
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin, Peter R. Thorne, Gary D. Housley, Srdjan M. Vlajkovic   +3 more
doaj   +1 more source

Axon regeneration after optic nerve injury in rats can be improved via PirB knockdown in the retina

Cell & Bioscience, 2021
Background In the central nervous system (CNS), three types of myelin-associated inhibitors (MAIs) exert major inhibitory effects on nerve regeneration: Nogo-A, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp).
Mei Yang, Lan Jian, Wei Fan, Xing Chen, Huan Zou, Yanming Huang, Xiaofan Chen, Yuan-Guo Zhou, Rongdi Yuan   +8 more
doaj   +1 more source

Differential spatial distribution of HNF4α isoforms during dysplastic progression of intraductal papillary mucinous neoplasms of the pancreas

Scientific Reports, 2023
Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions.
Jahg Wong, Vincent Q. Trinh, Nidhi Jyotsana, Jumanah F. Baig, Frank Revetta, Chanjuan Shi, Anna L. Means, Kathleen E. DelGiorno, Marcus Tan   +8 more
doaj   +1 more source

G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions [PDF]

Purinergic Signalling, 2012
The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors (ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and pyrimidine mono- and dinucleotides) has recently advanced significantly leading to selective ligands.
Kenneth A, Jacobson, Ramachandran, Balasubramanian, Francesca, Deflorian, Zhan-Guo, Gao   +3 more
openaire   +2 more sources

Expression and biological activity of two recombinant polypeptides related to subunit 1 of the interferon-a receptor

Brazilian Journal of Medical and Biological Research, 2000
Abnormal production of interferon alpha (IFN-a) has been found in certain autoimmune diseases and can be also observed after prolonged therapy with IFN-a.
S. Yoon, R.D.C. Hirata, N.Y. Nguyen, R. Curi, M. Russo, M.H. Hirata   +5 more
doaj   +1 more source

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

Frontiers in Cellular Neuroscience, 2019
Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory response, which comprises a rapid initial increase in breathing followed by a slower secondary ...
Robert J. Reklow, Tucaaue S. Alvares, Yong Zhang, Ana P. Miranda Tapia, Vivian Biancardi, Alexis K. Katzell, Sara M. Frangos, Megan A. Hansen, Alexander W. Toohey, Carol E. Cass, James D. Young, Silvia Pagliardini, Detlev Boison, Gregory D. Funk   +13 more
doaj   +1 more source