Results 31 to 40 of about 1,469,677 (296)
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin +3 more
doaj +1 more source
Axon regeneration after optic nerve injury in rats can be improved via PirB knockdown in the retina
Background In the central nervous system (CNS), three types of myelin-associated inhibitors (MAIs) exert major inhibitory effects on nerve regeneration: Nogo-A, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp).
Mei Yang +8 more
doaj +1 more source
G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions [PDF]
The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors (ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and pyrimidine mono- and dinucleotides) has recently advanced significantly leading to selective ligands.
Kenneth A, Jacobson +3 more
openaire +2 more sources
Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L [PDF]
Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures, which they themselves do not remain a part of.
Cato, L. +7 more
core +1 more source
Abnormal production of interferon alpha (IFN-a) has been found in certain autoimmune diseases and can be also observed after prolonged therapy with IFN-a.
S. Yoon +5 more
doaj +1 more source
Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions.
Jahg Wong +8 more
doaj +1 more source
BACL is a novel brain-associated, non-NKC-encoded mammalian C-type lectin-like receptor of the CLEC2 family [PDF]
Natural Killer Gene Complex (NKC)–encoded C-type lectin-like receptors (CTLRs) are expressed on various immune cells including T cells, NK cells and myeloid cells and thereby contribute to the orchestration of cellular immune responses.
Mittelbronn, Michel Guy André +11 more
core +1 more source
Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory response, which comprises a rapid initial increase in breathing followed by a slower secondary ...
Robert J. Reklow +13 more
doaj +1 more source
Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
B. F. King +17 more
core +1 more source
Peroxisome proliferator-activated receptor-γ (PPARγ) is a master regulator of adipogenesis, and alterations in its function are associated with various pathological processes related to metabolic syndrome.
Tingting Cui +27 more
doaj +1 more source

