Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]
, 2002 Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R. +4 more
core +1 more source
Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: A hypothesis [PDF]
, 2012 Despite extensive understanding of sleep regulation, the molecular-level cause and function of sleep are unknown. I suggest that they originate in individual neurons and stem from increased production of protein fragments during wakefulness.
Varshavsky, Alexander
core +1 more source
Towards a revised nomenclature for P1 and P2 receptors
Trends in Pharmacological Sciences, 1997 8
B. Fredholm +7 more
openaire +3 more sources
Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling [PDF]
, 2014 Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8.
Campbell, David +7 more
core +3 more sources
ATP and Adenosine in the Retina and Retinal Diseases
Frontiers in Pharmacology, 2021 Extracellular ATP and its ultimate degradation product adenosine are potent extracellular signaling molecules that elicit a variety of pathophysiological pathways in retina through the activation of P2 and P1 purinoceptors, respectively.
Shan-Shan Ye +3 more
doaj +1 more source
Protein synthesis at synaptic sites on dendrites [PDF]
, 2001 Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous ...
Schuman, Erin M., Steward, Oswald
core +1 more source
Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells. [PDF]
PLoS ONE, 2015 CD16a and CD16b are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively. Both CD16 isoforms undergo a rapid down-regulation in expression by ADAM17-mediated proteolytic cleavage upon cell activation by various ...
Yawu Jing +6 more
doaj +1 more source
NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. [PDF]
, 1995 NKR-P1A is a lectinlike surface molecule expressed on rat natural killer (NK) cells. NKR-P1A has structural and functional features of an activating NK cell receptor, but a requirement for NKR-P1A in target cell lysis has not been determined.
Nakamura, MC +3 more
core
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Apoptotic Platelet Events Are Not Observed in Severe von Willebrand Disease-Type 2B Mutation p.V1316M. [PDF]
PLoS ONE, 2015 Thrombocytopenia and increased platelet clearance observed in von Willebrand disease-type 2B (VWD-2B) may be explained by platelet apoptosis triggered by the constitutive binding of VWF to its receptor, glycoprotein Ib (GPIb).
Eliane Berrou +12 more
doaj +1 more source