Results 41 to 50 of about 1,469,677 (296)

Purinergic Regulation of Food and Fat Intakes in Broiler’s Central Nervous System [PDF]

Iranian Journal of Veterinary Medicine, 2021
BACKGROUND: Adenosine has many physiological roles in the brain, and in rodents, it changes food intake when applied centrally. OBJECTIVES: We investigated the effect of central injection of the purine molecule adenosine on both food and fat intakes in ...
Sahel Motaghi, Hossein Jonaidi, Alireza Bashiri, Samaneh Nouri Gooshki   +3 more
doaj   +1 more source

Towards a revised nomenclature for P1 and P2 receptors

Trends in Pharmacological Sciences, 1997
8
B. Fredholm, M. Abbracchio, G. Burnstock, G. Dubyak, T. Harden, K. Jacobson, U. Schwabe, M. Williams   +7 more
openaire   +3 more sources

Purinergic Signalling: Therapeutic Developments

Frontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj   +1 more source

Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate. [PDF]

PLoS ONE, 2014
Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation. We recently reported that these compounds antagonize
Hung Chang, Ivan B Yanachkov, Edward J Dix, Milka Yanachkova, Youfu Li, Marc R Barnard, George E Wright, Alan D Michelson, Andrew L Frelinger   +8 more
doaj   +1 more source

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4) [PDF]

, 2012
Proteinase-activated receptors 4 (PAR4) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation.
Robben, Joris, Cooke, Alexandra E., Nilsson, Mary, Mundell, Stuart, Plevin, Robin, Cunningham, Margaret R., Gould, Gwyn W., McIntosh, Kathryn A., Milligan, Graeme, Pediani, John D.   +9 more
core   +4 more sources

Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

Frontiers in Pharmacology, 2023
Graphical AbstractAdenosine mediates sleep, torpor and hibernation through P1 receptors. Recent reasearch has shown that P1 receptors play a vital role in the regulation of sleep-wake, torpor and hibernation-like states. In this review, we focus on the roles and neurobiological mechanisms of the CNS adenosine and P1 receptors in these three states ...
Wei-Xiang Ma, Ping-Chuan Yuan, Hui Zhang, Ling-Xi Kong, Michael Lazarus, Wei-Min Qu, Yi-Qun Wang, Zhi-Li Huang   +7 more
openaire   +3 more sources

() The sequences of the wt P1, (-1C)-P1, (-3m)-P1 and (-5U)-P1 duplexes

, 2011
Copyright information:Taken from "Thermodynamics and kinetics for base-pair opening in the P1 duplex of the group I ribozyme"Nucleic Acids Research 2007;35(9):2965-2974.Published online 16 Apr 2007PMCID:PMC1891724.© 2007 The Author(s) The numbering of ...
Joon-Hwa Lee (29631), Arthur Pardi (29632)   +1 more
core   +1 more source

Loop B is a major structural component of the 5-HT3 receptor [PDF]

, 2008
The 5-HT3 receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence of six peptide loops (A-F).
Thompson, Andrew J., Thompson, A.J., M. Lochner, Lummis, S. C. R., Lummis, S.C.R., S. C. R. Lummis, Lochner, M., A. J. Thompson, Lochner, Martin, Thompson, Andrew James   +9 more
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source