Results 1 to 10 of about 481,764 (224)
Cancers, 2019 p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Earlier observations on p21 knockout models emphasized the role of this protein in cell cycle arrest under the p53 transcription
Bahar Shamloo, Sinem Usluer
semanticscholar +3 more sources
LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling [PDF]
Nature Communications, 2019 While the antiandrogen enzalutamide (Enz) extends the castration resistant prostate cancer (CRPC) patients’ survival an extra 4.8 months, it might also result in some adverse effects via inducing the neuroendocrine differentiation (NED).
Jie Luo +11 more
semanticscholar +3 more sources
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing [PDF]
Nature Cell Biology, 2016 The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could also be oncogenic, through a mechanism that has so far remained obscure.
P. Galanos +30 more
semanticscholar +5 more sources
LincRNA-p21 suppresses target mRNA translation. [PDF]
Molecular Cell, 2012 Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitment of let-7/Ago2 to lincRNA-p21, leading to lower lincRNA-p21 stability.
Je-Hyun Yoon +9 more
semanticscholar +4 more sources
Cell cycle regulation: p53-p21-RB signaling
Cell Death and Differentiation, 2022 The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms complexes with the E2F
K. Engeland
semanticscholar +1 more source
An E2F1/DDX11/EZH2 Positive Feedback Loop Promotes Cell Proliferation in Hepatocellular Carcinoma
Frontiers in Oncology, 2021 Hepatocellular carcinoma (HCC) accounts for one of the leading causes of cancer-related death, and is attributed to the dysregulation of genes involved in genome stability.
Shu-Guang Su +5 more
doaj +1 more source
The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype [PDF]
PeerJ, 2013 The end replication problem, which occurs in normal somatic cells inducing replicative senescence, is solved in most cancer cells by activating telomerase.
Lei Zhao, Michael Wink
doaj +2 more sources
Frontiers in Immunology, 2022 Fibrosing interstitial lung disease (ILD) develops due to the impaired reparative processes following lung tissue damage. Cellular senescence has been reported to contribute to the progression of fibrosis. However, the mechanisms by which these senescent
Zento Yamada +9 more
doaj +1 more source
p21 produces a bioactive secretome that places stressed cells under immunosurveillance
Science, 2021 Description The clock is ticking for senescent cells Senescent cells promote their own recognition and removal through the immune system by generating a bioactive secretome called the senescence-associated secretory phenotype (SASP).
Ines Sturmlechner +18 more
semanticscholar +1 more source
Frontiers in Oncology, 2023 BackgroundMany studies have reported that N6-methyladenosine (m6A) modification plays a critical role in the epigenetic regulation of organisms and especially in the pathogenesis of malignant diseases.
Fuming Xie +32 more
doaj +1 more source