Results 91 to 100 of about 481,863 (320)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

New functional activities for the p21 family of CDK inhibitors.

Genes & Development, 1997
The association of cdk4 with D-type cyclins to form functional kinase complexes is comparatively inefficient. This has led to the suggestion that assembly might be a regulated step. In this report we demonstrate that the CDK inhibitors p21(CIP), p27(KIP),
J. LaBaer, M. Garrett, L. Stevenson, J. Slingerland, Charanjit Sandhu, H. S. Chou, A. Fattaey, E. Harlow   +7 more
semanticscholar   +1 more source

HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis [PDF]

, 2009
Penile verrucous carcinoma is a rare disease and little is known of its aetiology or pathogenesis. In this study we examined cell-cycle proteins expression and correlation with human papillomavirus infection in a series of 15 pure penile verrucous ...
A Ouban, AL Cubilla, AL Cubilla, AL Cubilla, AL Cubilla, AL Cubilla, AL Seixas, AS Masih, AS Narayana, B Kleter, C Dianzani, C Missero, Catherine Corbishley, CB Bunker, CL Haycox, Daniel M Berney, David M Prowse, DE Johnson, DM Prowse, E Ferreux, EF Velazquez, Elena Ktori, Elzbieta Stankiewicz, FT Kraus, GD Higgins, IB Roninson, Jack Cuzick, JC Noel, JR Nevins, KH Cuesta, KW Chan, KY Lam, KY Lam, L Gregoire, Laurence Ambroisine, LC Cubilla, LH Sobin, LL Villa, LV Ackerman, M Gualco, M Senba, M Serrano, M Wong, MA Rubin, MR Cupp, MT Kiyabu, Nicholas Watkin, PA Adegboyega, PA Hall, PH McKee, S Pilotti, Sakunthala C Kudahetti, SL Harris, T Sano, TH Cheung, VA Tron, VA Varma, Xiaoxi Zhang, Y Koyamatsu   +58 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Developmental sensory experience balances cortical excitation and inhibition. [PDF]

, 2010
Early in life, neural circuits are highly susceptible to outside influences. The organization of the primary auditory cortex (A1) in particular is governed by acoustic experience during the critical period, an epoch near the beginning of postnatal ...
Barker, Alison J, Dorrn, Anja L, Froemke, Robert C, Schreiner, Christoph E, Yuan, Kexin   +4 more
core   +3 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Establishment of skin photoaging model and preliminary mechanism of senescence in keratinocytes cell line HaCaT

Di-san junyi daxue xuebao, 2019
Objective To establish an efficient skin photoaging model in HaCaT cells and investigate the possible signaling pathways of photoaging of skin. Methods After HaCaT cells were exposed to UVB at 30 mJ/cm2, cell proliferation and cell cycle was detected by ...
LIU Chuan, HUANG Xin, WANG Ping, PAN Yun, CAO Di   +4 more
doaj   +1 more source

The p53/p21 Complex Regulates Cancer Cell Invasion and Apoptosis by Targeting Bcl-2 Family Proteins.

Cancer Research, 2017
The tumor suppressor p53 binds prosurvival Bcl-2 family proteins such as Bcl-w and Bcl-XL to liberate Bax, which in turn exerts proapoptotic or anti-invasive functions depending on stress context.
Eun Mi Kim, Chan-Hun Jung, Jongdoo Kim, Sang-Gu Hwang, Jong Kuk Park, H. Um   +5 more
semanticscholar   +1 more source

Cytoplasmic translocation of p21 mediates NUPR1‐induced chemoresistance [PDF]

FEBS Letters, 2012
The expression of Nuclear Protein 1 (NUPR1) is associated with chemoresistance in multiple malignancies. We previously reported that NUPR1 functions as a transcriptional cofactor for the p300–p53 complex and transcriptionally regulates p21 expression.
Vincent, Andrew J., Ren, Suping, Harris, Lillianne G., Devine, Daniel J., Samant, Rajeev S., Fodstad, Oystein, Shevde, Lalita A.   +6 more
openaire   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source