Results 51 to 60 of about 481,863 (320)
Kouqiang hemian waike zazhi[Objective:] To explore the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A/p21) in the healing process of tooth extraction wounds in diabetic mice and the effect on migration and polarization of macrophages.
ZHU Jiayu +5 more
doaj +1 more source
CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point [PDF]
, 2013 Cell cycle progression, including genome duplication, is orchestrated by cyclin-dependent kinases (CDKs). CDK activation depends on phosphorylation of their T-loop by a CDK-activating kinase (CAK).
Bisteau, Xavier +8 more
core +4 more sources
Biotechnology & Biotechnological Equipment, 2021 Multiple myeloma (MM) is the most common bone marrow malignancy which is defined with bone marrow infiltration of more than 10% of terminally differentiated plasma cells sive myeloma cells.
Jurijs Nazarovs +5 more
doaj +1 more source
Nature Communications, 2017 Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21.
A. Barr +7 more
semanticscholar +1 more source
Multifaceted p21 in carcinogenesis, stemness of tumor and tumor therapy.
World Journal of Stem Cells, 2020 Cancer cells possess metabolic properties that are different from those of benign cells. p21, encoded by CDKN1A gene, also named p21Cip1/WAF1, was first identified as a cyclin-dependent kinase regulator that suppresses cell cycle G1/S phase and ...
Boduan Xiao +5 more
semanticscholar +1 more source
LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint [PDF]
, 2014 The p53-regulated long noncoding RNA lincRNA-p21 has been proposed to act in trans via several mechanisms ranging from repressing genes in the p53 transcriptional network to regulating mRNA translation and protein stability.
Dimitrova, Nadya +10 more
core +1 more source
P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis
Онкогематология, 2014 The role of p53 family proteins, both in the pathogenesis of chronic lymphoproliferative disorders, and in aspects of the growi ng interest in thetherapeutic potential of so-called small molecules capable of influencing the regulatory "relationship" of ...
P. M. Kondratovskiy +2 more
doaj +1 more source
p21 can be a barrier to ferroptosis independent of p53
Aging, 2020 Traditionally, the p21 protein has been viewed as limiting cancer progression and promoting aging. In contrast, there are reports that p21 can enhance cancer survival and limit tissue damage, depending on the tissue of origin and type of stressor ...
D. Venkatesh, B. Stockwell, C. Prives
semanticscholar +1 more source
Cuts and coproducts of massive triangle diagrams [PDF]
, 2015 Relations between multiple unitarity cuts and coproducts of Feynman integrals are extended to allow for internal masses. These masses introduce new branch cuts, whose discontinuities can be derived by placing single propagators on shell and identified as
Abreu, Samuel +2 more
core +4 more sources
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence [PDF]
The EMBO Journal, 2002 The cyclin-dependent kinase (CDK) inhibitor p21(Waf1/Cip1/Sdi1) was identified initially as a gene induced in senescent cells and itself has been shown to cause permanent growth arrest/senescence. Reactive oxygen species (ROS), a byproduct of oxidative processes, can also induce an irreversible growth arrest similar to senescence. Here we show that p21
Macip, S. +6 more
openaire +3 more sources