Results 51 to 60 of about 162,345 (168)

Establishment of skin photoaging model and preliminary mechanism of senescence in keratinocytes cell line HaCaT

Di-san junyi daxue xuebao, 2019
Objective To establish an efficient skin photoaging model in HaCaT cells and investigate the possible signaling pathways of photoaging of skin. Methods After HaCaT cells were exposed to UVB at 30 mJ/cm2, cell proliferation and cell cycle was detected by ...
LIU Chuan, HUANG Xin, WANG Ping, PAN Yun, CAO Di   +4 more
doaj   +1 more source

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, EarlyView.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source

Cytoplasmic p21 induced by p65 prevents doxorubicin-induced cell death in pancreatic carcinoma cell line

Journal of Biomedical Science, 2012
Background Studies have shown the existence of p21 induction in a p53-dependent and -independent pathway. Our previous study indicates that DOX-induced p65 is able to bind the p21 promoter to activate its transactivation in the cells.
Zhou YingQi, Li Gang, Ji Yuan, Liu Chen, Zhu JingPing, Lu YanJun   +5 more
doaj   +1 more source

Cytoplasmic translocation of p21 mediates NUPR1‐induced chemoresistance [PDF]

FEBS Letters, 2012
The expression of Nuclear Protein 1 (NUPR1) is associated with chemoresistance in multiple malignancies. We previously reported that NUPR1 functions as a transcriptional cofactor for the p300–p53 complex and transcriptionally regulates p21 expression.
Vincent, Andrew J., Ren, Suping, Harris, Lillianne G., Devine, Daniel J., Samant, Rajeev S., Fodstad, Oystein, Shevde, Lalita A.   +6 more
openaire   +2 more sources

Where Most Frameworks Degrade: Flexible Bimetallic Phosphonate Crystals as pH‐Universal Supercapacitor Electrodes

Advanced Functional Materials, EarlyView.
Plastically flexible single crystals of the bimetallic phosphonate framework [Cu(2,2′‐bpy)VO(O3PC6H5)2] combine mechanical adaptability with robust pseudocapacitive charge storage. The material delivers about 140 Fg−1 at pH 4 and pH 10 and remains stable across pH 2‐12, enabling energy storage under comparatively mild electrolyte conditions.
Tim Müller, Jean G. A. Ruthes, Biswajit Battacharya, Dorothee Silbernagl, Patrik Tholen, Aysenur Limon, Gülsüm Kinik, Christoph Janiak, Markus Suta, Franziska Emmerling, Volker Presser, Gündoğ Yücesan   +11 more
wiley   +1 more source

Long-term prognostic value of the combination of EORTC risk group calculator and molecular markers in non-muscle-invasive bladder cancer patients treated with intravesical Bacille Calmette-Guérin

Urology Annals, 2011
Background and Objectives: To evaluate the long-term prognostic value of the combination of the EORTC risk calculator and proapoptotic, antiapoptotic, proliferation, and invasiveness molecular markers in predicting the outcome of intermediate- and high ...
Sultan S Alkhateeb, Mischel Neill, Sas Bar-Moshe, Bas Van Rhijn, David M Kakiashvili, Neil Fleshner, Michael Jewett, Michel Petein, Claude Schulman, Sally Hanna, Peter J Bostrom, Thierry Roumeguere, Shahrokh F Shariat, Sandrine Rorive, Alexandre R Zlotta   +14 more
doaj   +1 more source

Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways

Journal of Experimental & Clinical Cancer Research, 2020
Background GLYR1 has a high mutation frequency in microsatellite instability colorectal cancer (MSI CRC) and is presumed to be a novel tumor suppressor. However, the role of GLYR1 in tumors has never been studied.
Zhiyan Hu, Ting Long, Yidan Ma, Jiaxian Zhu, Lingfang Gao, Yan Zhong, Xia Wang, Xiaoyan Wang, Zuguo Li   +8 more
doaj   +1 more source

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Expression of p53, Ki67, epidermal growth factor receptor, transforming growth-factorα, and p21 in primary and secondary hyperparathyroidism

Indian Journal of Endocrinology and Metabolism, 2014
Background: Secondary hyperparathyroidism (SH) is major problem in chronic renal failure. There are studies to examine proliferation and apoptosis associated biomarkers expressions in parathyroid lesions to reveal specific features.
Saime Paydas, Arbil Acikalim, Bulent Kaya, Bermal Hasbay Bicer, Mehmet Ulker, Orhan Demircan, Aysun Uguz, Mustafa Balal, Gurhan Sakman, Yasar Sertdemir, Refika Karaer, Eda Altun   +11 more
doaj   +1 more source

Self‐Cooling Molecular Spin Qudits

Advanced Materials, EarlyView.
A material made of [GdEr] molecular dimers can encode a qudit and perform as a magnetic refrigerant. Microwave resonant pulses coherently manipulate its 16 spin states, while direct demagnetization measurements cool the material and a device down to temperatures below 1 K.
Elías Palacios, David Aguilà, David Gracia, Diamatoula Maniaki, Leoní A. Barrios, Alessandro Chiesa, Jesús I. Martínez, Valentin Novikov, Olivier Roubeau, Stefano Carretta, Marco Evangelisti, Guillem Aromí, Fernando Luis   +12 more
wiley   +1 more source