Results 61 to 70 of about 481,863 (320)
Small molecule induced reactivation of mutant p53 in cancer cells [PDF]
, 2013 The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams +58 more
core +2 more sources
rap1 p21 regulates the interaction of ras p21 with RGL, a new effector protein of ras p21 [PDF]
FEBS Letters, 1995 We have recently found that ralGDS family members (RGL and ralGDS) are putative effector proteins of ras p21. rap1 p21 is a small GTP‐binding protein which has the same amino acid sequence as the effector loop of ras p21. We examined the effect of rap1 p21 on the interaction of ras p21 with RGL.
Ikeda, Masahiro +4 more
openaire +2 more sources
Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]
, 1993 The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico +6 more
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Journal of Pharmacopuncture, 2004 Objectives : In order to measure the efficacy of cultivated wild ginseng distilled herbal acupuncture by concentration level, we've treated A549 human lung cancer lines with different concentrations of cultivated wild ginseng distilled herbal acupuncture
Hee-Chul Cho, Sun-Gu Lee, Ki-Rok Kwon
doaj +1 more source
Veterinary Sciences, 2022 Due to the high incidence of mammary tumors in dogs, it is important to elucidate the pathogenesis of these tumors in veterinary medicine. Radiation therapy is often used to treat mammary tumors that target DNA lesions.
Kei Shimakawa +10 more
doaj +1 more source
Two-photon decay of the neutral pion in lattice QCD [PDF]
, 2012 We perform non-perturbative calculation of the \pi^0 to {\gamma}{\gamma} transition form factor and the associated decay width using lattice QCD. The amplitude for two-photon final state, which is not an eigenstate of QCD, is extracted through an ...
E. Shintani +11 more
core +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Cardiomyocyte Proliferative Capacity Is Restricted in Mice With Lmna Mutation
Frontiers in Cardiovascular Medicine, 2021 LMNA is one of the leading causative genes of genetically inherited dilated cardiomyopathy (DCM). Unlike most DCM-causative genes, which encode sarcomeric or sarcomere-related proteins, LMNA encodes nuclear envelope proteins, lamin A and C, and does not ...
Kenji Onoue +12 more
doaj +1 more source
Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism [PDF]
, 2018 In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes.
Billi, Monia +9 more
core +1 more source