Results 21 to 30 of about 47,767 (140)
Expression of CyclinD1, CDC25B and p27 protein in gastric carcinoma And it s clinical significance
Asian Journal of Medical Sciences, 2021 Background: Gastric cancer is a common digestive tract tumor in our China, with high morbidity and mortality. Similar with other tumors, the occurrence of gastric cancer was also a complex pathophysiological process, regulated by a variety of oncogenes ...
Wang Jun
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The Speedy A, Cdk2, p27 triangle [PDF]
Cell Cycle, 2016 The regulation of cell-cycle phase transition is dependent upon the interactions of 3 classes of proteins; cyclin-dependent kinases (Cdks), cyclins and Cdk inhibitors such as the Cip/Kip family mem...
Matthew, R Dewhurst, Philipp, Kaldis
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Cell type-specific effects of p27KIP1 loss on retinal development
Neural Development, 2017 Background Cyclin-dependent kinase (CDK) inhibitors play an important role in regulating cell cycle progression, cell cycle exit and cell differentiation.
Mariko Ogawa +4 more
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Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma
Molecular Oncology, 2011 Cathepsin B and urokinase plasminogen activator receptor (uPAR) are overexpressed in gliomas. Deregulation of the G1 phase cell cycle machinery is a common feature of cancers. p27Kip1 (p27) is one of the major cyclin‐CDK regulators in the G1 phase.
Sreelatha Gopinath +6 more
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Respiratory Research, 2007 Background Hypoxia induces the proliferation of pulmonary arterial smooth muscle cell (PASMC) in vivo and in vitro, and prostacyclin analogues are thought to inhibit the growth of PASMC.
Miyamori Isamu +5 more
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ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′UTR [PDF]
Genes & Development, 2002 p27Kip1 restrains cell proliferation by binding to and inhibiting cyclin-dependent kinases. To investigate the mechanisms of p27 translational regulation, we isolated a complete p27 cDNA and identified an internal ribosomal entry site (IRES) located in its 5′UTR.
Kullmann, M. +3 more
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Laboratory Animal Research, 2018 To evaluate the carcinogenicity of p27 knockout (KO) mice with RNA-guided endonuclease (RGENs)-mediated p27 mutant exon I gene (IΔ), alterations in the carcinogenic phenotypes including tumor spectrum, tumor suppressor proteins, apoptotic proteins and ...
Jun Young Choi +11 more
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Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical region
Cell Division, 2006 Background p27kip1 (p27) is a multifunctional protein implicated in regulation of cell cycling, signal transduction, and adhesion. Its activity is controlled in part by Phosphatylinositol-3-Kinase (PI3K)/Akt1 signaling, and disruption of this regulatory ...
Nacusi Lucas P, Sheaff Robert J
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BMC Cell Biology, 2002 Background The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased ...
Schulz Holger, Lu Lifang, Wolf Dieter A
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BMJ Supportive & Palliative Care, 2013 BackgroundAutumn 2013 the hospice relocates to its new 20-bedded facility. To offer a more worthwhile and less segregated volunteering experience, a generic volunteer role was created to replace Ward Helpers, Receptionists and Day Therapy Helpers.AimOffer a positive, friendly greeting to visitors via a well-informed, approachable “Host”Create a ...
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