Results 51 to 60 of about 47,767 (140)

Nexrutine Inhibits Cancer Cell Growth as a Consequence of Mitochondrial Damage and Mitophagy

Cellular Physiology and Biochemistry, 2015
Background/Aims: Nexrutine is an herbal extract of Phellodendron amurense and has been used as nutrient supplement in China as well as America. Potential protection effect of Nexrutine has been reported. Methods: To investigate the mechanism of Nexrutine,
Xiang Wu, Shao-ming Zhou, Yi-Ling Ding, Ying-ping Gong, Weiqi Zeng, Yi Cui   +5 more
doaj   +1 more source

UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27

Neurobiology of Disease, 2009
The UBE3A/E6-AP is known to function both as an E3 ubiquitin ligase of the ubiquitin proteasome system and as a transcriptional coactivator. E6-AP shows brain-specific imprinting and loss of function of maternally inherited E6-AP causes Angelman syndrome.
Amit Mishra, Swetha K. Godavarthi, Nihar Ranjan Jana   +2 more
doaj   +1 more source

Comparison of p27 Gene Expression of Promastigote and Amastigote Forms of Leishmania major (MRHO/IR/75/ER) by Real-time RT-PCR

Iranian Journal of Parasitology, 2018
Background: Cutaneous leishmaniasis (CL) is one of the world health problems. Leishmania major is the etiological agent of zoonotic cutaneous leishmaniasis (ZCL).
Samira ELIKAEE, Mehdi MOHEBALI, Hamid ESLAMI, Sassan REZAEI, Hamid Reza NAJAFIAN, Elham KAZEMI-RAD, Hossein KESHAVARZ, Mohammad Reza ESHRAGHIAN, Homa HAJJARAN, Mohammad Ali OSHAGHI, Sara AYAZIAN MAVI   +10 more
doaj  

NNMT/1‐MNA Promote Cell‐Cycle Progression of Breast Cancer by Targeting UBC12/Cullin‐1‐Mediated Degradation of P27 Proteins

Advanced Science
Cell cycle dysregulation is a defining feature of breast cancer. Here, 1‐methyl‐nicotinamide (1‐MNA), metabolite of nicotinamide N‐methyltransferase(NNMT) is identified, as a novel driver of cell‐cycle progression in breast cancer. NNMT, highly expressed
Yilei Ma, Xucheng Huang, Yanzhong Wang, Yinjiao Lei, Jinwei Yu, Shaobo Yu, Yuzhen Gao, Jun Yang, Feng Zhao, Haitao Yu, Jin Zeng, Yadong Chu, Min Yang, Guoli Li, Xinyou Xie, Jun Zhang   +15 more
doaj   +1 more source

Böbrek hücreli karsinom olgularında p53 ve p27`nin immunhistokimyasal değerlendirilmesi p27 polimorfizmi

, 2021
67
openaire   +1 more source

Circular RNA TAF4B targeting MFN2 accelerates cell growth in bladder cancer through p27 depression and AKT activation

Frontiers in Immunology
IntroductionBladder cancer (BCa) is a common malignancy in the urinary tract. It has high recurrence rates and often requires microscopic examination, which presents significant challenges in clinical treatment.
Xiaoting Zhang, Jia Xu, Guangzhen Zhuang, Yiting Wang, Xiaofeng Li, Xiaohui Zhu   +5 more
doaj   +1 more source

EXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2007
BACKGROUND AND OBJECTIVE: Different studies have reported different results for expression of cell-cycle regulator genes, P53 and P27kip1, and proliferation marker Ki-67 in gastric cancer and their correlation with clinicohistopathologic parameters and ...
E Shafigh,, Y Abdolazimi, SH Shafaei, M Haji Ahmadi   +3 more
doaj  

Myc and Skp2 overexpression promotes p27 ubiquitination and degradation in Ewing Sarcoma. [PDF]

PLoS One
Kubota Y, Kawano M, Itonaga I, Kaku N, Tanaka K.   +4 more
europepmc   +1 more source

HORMAD1 inhibits senescence and promotes proliferation of triple negative breast cancer by facilitating ubiquitination-mediated degradation of p27. [PDF]

Am J Transl Res
Zong B, Lei J, Lou M, Yang F, Liu S, Li Z.   +5 more
europepmc   +1 more source

Selinexor enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by regulating the BAX/Bcl-2/PUMA apoptotic pathway and the XPO1/p27 cell cycle pathway. [PDF]

Front Oncol
Du S, Wang L, Chen C, Sun Y, Liu Q, Shi J, Zhang F, Wang K, Cui C.   +8 more
europepmc   +1 more source