Results 51 to 60 of about 126,105 (250)

The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells

BMC Cell Biology, 2002
Background The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased ...
Schulz Holger, Lu Lifang, Wolf Dieter A
doaj   +1 more source

Growth Arrest-Specific Transcript 5 (GAS5) Exerts Important Roles on the Treatment of BM45 Cells of Liver Cirrhosis

Molecular Therapy: Nucleic Acids, 2020
Bone marrow (BM)-derived CD45 (BM45) cells were demonstrated to exhibit an improved antifibrotic effect on the treatment of CCL4-induced liver fibrosis by significantly increasing the level of matrix metalloproteinase 9 (MMP-9).
Xing Lu, Ming Jiang, Juan Tian, Wei Liu, Fan Wu, Lijuan Yu, Guohui Feng, Shan Zhong, Ying Xiang, Hua Wen   +9 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Coulomb dissociation of P 27 at 500 MeV/u [PDF]

, 2016
The proton-capture reaction Si26(p,γ)P27 was studied via Coulomb dissociation (CD) of P27 at an incident energy of about 500 MeV/u. The three lowest-lying resonances in P27 have been populated and their resonance strengths have been measured. In addition,
A. Chatillon, A. Wagner, C. Langer, C. Muentz, C. Nociforo, C. Rodríguez Tajes, C. Wimmer, D. Cortina-Gil, D. Galaviz, D. M. Rossi, E. Casarejos, F. Hammache, F. Wamers, H. Alvarez-Pol, H. Geissel, H. Johansson, H. Simon, H. Weick, J. Hoffman, J. Marganiec, J. Stroth, K. Boretzky, K. Larsson, K. Mahata, K. Sümmerer, M. Heil, M. Stanoiu, M. Wiescher, N. Kurz, null null, O. Kiselev, R. Plag, S. Beceiro Novo, S. Giron, S. Paschalis, S. Typel, T. Aumann, T. Le Bleis, U. Datta-Pramanik, U. Greife, W. Ott, W. Prokopowicz, Yu. A. Litvinov, Z. Elekes, Z. Fulop   +44 more
core   +3 more sources

P27 Volunteer hosts [PDF]

BMJ Supportive & Palliative Care, 2013
BackgroundAutumn 2013 the hospice relocates to its new 20-bedded facility. To offer a more worthwhile and less segregated volunteering experience, a generic volunteer role was created to replace Ward Helpers, Receptionists and Day Therapy Helpers.AimOffer a positive, friendly greeting to visitors via a well-informed, approachable “Host”Create a ...
openaire   +1 more source

PKC-dependent phosphorylation of p27 at T198 contributes to p27 stabilization and cell cycle arrest [PDF]

Cell Cycle, 2012
In this manuscript, we present experimental evidence that PKCs phosphorylate p27 at T198 in vitro and in vivo, resulting in p27 stabilization and cell cycle arrest in MCF-7 and HeLa cells. Our findings indicate that (1) recombinant PKCα, βII, δ, η and θ isoforms phosphorylate, in in vitro kinase assays, wild-type recombinant p27 protein expressed in E.
Fernanda, De Vita, Miriam, Riccardi, Donatella, Malanga, Marianna, Scrima, Carmela, De Marco, Giuseppe, Viglietto   +5 more
openaire   +2 more sources

Emerging Roles of SKP2 in Cancer Drug Resistance

Cells, 2021
More than half of all cancer patients receive chemotherapy, however, some of them easily acquire drug resistance. Resistance to chemotherapy has become a massive obstacle to achieve high rates of pathological complete response during cancer therapy.
Ting Wu, Xinsheng Gu, Hongmei Cui
doaj   +1 more source

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia [PDF]

, 2011
Suppression of apoptosis by TP53 mutation contributes to resistance of acute myeloid leukemia (AML) to conventional cytotoxic treatment. Using differentiation to induce irreversible cell cycle exit in AML cells could be a p53-independent treatment ...
Anjali Advani, Edward Copelan, James C. Mulloy, PhD, Jaroslaw Maciejewski, Kevin Link, Kwok-Peng Ng, Matt Kalaycio, Mikkael Sekeres, Quteba Ebrahem, Reda Mahfouz, Ronald Sobecks, Soledad Negrotto, Tomas Radivoyevitch, Xiaorong Gu, Yogen Saunthararajah, Zhenbo Hu   +15 more
core   +2 more sources

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source