Results 151 to 160 of about 199,121 (304)

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling. [PDF]

Stem Cells, 2020
Mousawi F, Peng H, Li J, Ponnambalam S, Roger S, Zhao H, Yang X, Jiang LH.   +7 more
europepmc   +1 more source

Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors [PDF]

, 2010
Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals.
Drenan, Ryan M., Grady, Sharon R., Lester, Henry A., Marks, Michael J., McIntosh, J. Michael, McKinney, Sheri, Miwa, Julie M., Patzlaff, Natalie E., Steele, Andrew D.   +8 more
core  

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source

Blue Mussel-Derived Bioactive Peptides PIISVYWK (P1) and FSVVPSPK (P2): Promising Agents for Inhibiting Foam Cell Formation and Inflammation in Cardiovascular Diseases

Marine Drugs
Atherosclerosis is a key etiological event in the development of cardiovascular diseases (CVDs), strongly linked to the formation of foam cells. This study explored the effects of two blue mussel-derived bioactive peptides (BAPs), PIISVYWK (P1) and ...
Chathuri Kaushalya Marasinghe, Jae-Young Je   +1 more
doaj   +1 more source

Multiscale Carbon‐Integrated Silicon Anode for Stable Cycling Under Practical Lithium‐Ion Battery Conditions

Advanced Energy Materials, EarlyView.
To overcome silicon anode instability, a hierarchical silicon/carbon composite fabricated from industrial waste via a scalable milling process is demonstrated. In‐depth post‐mortem analysis reveals how functional carbons—a CNT network and graphene shell—synergistically suppress degradation. This robust design delivers outstanding stability in practical
Young‐Ro Lee, Seong Chul Hong, Kyoungoh Kim, Jooha Park, Jihyeon Kim, Byungwook Kang, Youngsu Kim, Chaelin Lee, Soogyeong Son, Byungmo Cho, Junhyung Kim, Sang‐Gil Woo, Gwan‐Hyoung Lee, Kisuk Kang   +13 more
wiley   +1 more source

Alcohol‐Adduct Mediated Precursor Stabilization Strategies for Conformal SnO2 Layers in Highly Efficient and Stable Perovskite Solar Modules

Advanced Energy Materials, EarlyView.
An alcohol‐adduct‐mediated strategy is employed to stabilize tin isopropoxide for the formation of a homogeneous double electron transport layer (ETL) incorporating SnO2 nanoparticles (NPs). This double‐ETL exhibits improved optical and charge‐transport properties due to reduced defect density and better energy level alignment, resulting in high ...
You‐Hyun Seo, Eun Young Park, Chan Su Moon, Dong Gyu Lee, Junho Park, Fabian Rotermund, Gill Sang Han, Tae Kyung Lee, Nam Joong Jeon, Bong Joo Kang, Young Yun Kim   +10 more
wiley   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source