Results 161 to 170 of about 199,121 (304)

Mesenchymal stem cells delivered via a bioactive disordered peptide-hydrogel platform modulate early inflammation and enhance skeletal repair in a polytrauma model

Journal of Tissue Engineering
Over 30% of polytrauma patients with bone fractures suffer from impaired healing and nonunion due to persistent systemic inflammation. Existing biologic strategies for bone repair primarily focus on osteogenesis but are not designed to modulate systemic ...
Augustine Mark Saiz, Maryam Rahmati, Tony Daniel Baldini, Aneesh Satish Bhat, Soren David Johnson, Mengyao Liu, Renato Miguel Reyes, Shierly W. Fok, Mark A. Lee, Thaqif El Khassawna, D. C. Florian Wieland, André Lopes Marinho, Clement Blanchet, J. Kent Leach, Håvard Jostein Haugen   +14 more
doaj   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

A High‐Precision Dynamic Movement Recognition Algorithm Using Multimodal Biological Signals for Human–Machine Interaction

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This article describes a multimodal fusion data acquisition and processing system about electromyography for dynamic movement recognition and bioelectrical impedance for key posture recognition. In addition, a new dynamic–static fusion algorithm strategy is designed.
Chenhao Cao, Gang Ma, Zelin Chen, Yiming Ouyang, Hu Jin, Shiwu Zhang   +5 more
wiley   +1 more source

The P2-receptor-mediated Ca²⁺ signalosome of the human pulmonary endothelium - implications for pulmonary arterial hypertension. [PDF]

Purinergic Signal, 2019
Hennigs JK, Lüneburg N, Stage A, Schmitz M, Körbelin J, Harbaum L, Matuszcak C, Mienert J, Bokemeyer C, Böger RH, Kiefmann R, Klose H.   +11 more
europepmc   +1 more source

Material‐Based Intelligence: Autonomous Adaptation and Embodied Computation in Physical Substrates

Advanced Intelligent Systems, EarlyView.
This perspective formulates a unifying framework for Material‐Based Intelligence (MBI), defining the physical requirements for materials to achieve embodied action, active memory and embodied information processing through intrinsic nonequilibrium dynamics. The design of intelligent materials often draws parallels with the complex adaptive behaviors of
Vladimir A. Baulin, Rudolf M. Füchslin, Achille Giacometti, Helmut Hauser, Marco Werner   +4 more
wiley   +1 more source

Local Chemical Gradients in a Mammalian Cortex Measured In Vivo With a Silicon Nanodialysis Mass Spectrometry Platform

Angewandte Chemie, EarlyView.
Fluorescence image of the coronal slice of mouse brain where multiple neurochemicals have been measured in vivo with a nanodialysis platform coupled to CE‐MS to reveal strong millimeter‐scale spatial chemical gradients. Formation and maintenance of such local chemical compartments in the otherwise diffusion‐homogeneous cortex indicates strong ...
Weihua Shi, Keyin Li, Yu Ding, Alex G. Armstrong, Jonathan V. Sweedler, Yurii Vlasov   +5 more
wiley   +2 more sources

Climate change and perennial crop production: Evidence of yield impact and adaptation in California

American Journal of Agricultural Economics, EarlyView.
Abstract Perennial crops are economically important. They contribute to food security, providing essential nutrients that are often lacking in annual crops, and provide additional environmental benefits compared with annual crops. Despite their importance, empirical research on the impacts of climate change and adaptation on perennial crops remains ...
Yuanyuan Wen, Wei Zhang, Julian M. Alston   +2 more
wiley   +1 more source

Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation

Angewandte Chemie, EarlyView.
CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova, Manisha B. Walunj, Claudia Höbartner   +2 more
wiley   +2 more sources

Clinical, Behavioral and Neuroradiological Phenotype in an Italian Cohort of Patients With Xia Gibbs Syndrome: A Multicenter Cross‐Sectional Study and Systematic Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous variants in the AHDC1 gene are associated with Xia Gibbs Syndrome (XGS), a genetic disorder with a highly variable phenotype. Cognitive impairment, motor delay, language delay, neonatal hypotonia, and sleep apnea are considered “cardinal” signs of the disease.
Giulia Cinelli, Stefania Della Vecchia, Patrizia Bergonzini, Elisa Caramaschi, Elisabetta Spezia, Claudia Parenti, Simona Filomena Madeo, Laura Lucaccioni, Cavalleri Francesca, Marisa Pugliese, Federico Raviglione, Clara Colonna, Olga Calabrese, Ilaria Stanghellini, Maria Carmen Marongiu, Enrico Biagioni, Anna Rita Ferrari, Roberta Battini, Lorenzo Iughetti   +18 more
wiley   +1 more source

Vascular Abnormalities in Hypermobile Ehlers–Danlos Syndrome: A Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Hypermobile Ehlers–Danlos syndrome (hEDS), while generally free from severe vascular complications, may occasionally present with cardiac and vascular abnormalities that warrant specific investigation. While studies have been conducted on the prevalence of cardiac involvement, none have focused on vascular aspects. This retrospective study was
Thomas Gehin, Malika Foy, Robert Carlier, Valentin Renault, Karelle Benistan   +4 more
wiley   +1 more source