Results 211 to 220 of about 89,570 (263)
Restoring oscillatory dynamics in Alzheimer's disease: A laminar whole-brain model of serotonergic psychedelic effects. [PDF]
Netw NeurosciGendra JC +9 more
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Distinct membrane binding properties of the two non-visual arrestins. [PDF]
Commun BiolKilleen TD +11 more
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Ocular P2 receptors and glaucoma
Neuropharmacology, 2023Adenosine triphosphate (ATP), an energy source currency in cells, is released or leaked to the extracellular space under both physiological and pathological conditions. Extracellular ATP functions as an intercellular signaling molecule through activation of purinergic P2 receptors.
Youichi, Shinozaki +3 more
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Journal of the Autonomic Nervous System, 2000
Our understanding of the actions of extracellular ATP in controlling kidney function via stimulation of P2 receptors is still at an early stage. Recently, several groups, including our own, have begun to address this subject: in this brief review, we discuss some of these effects and speculate on likely function of extracellular nucleotides in the ...
M A, Bailey, K A, Hillman, R J, Unwin
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Our understanding of the actions of extracellular ATP in controlling kidney function via stimulation of P2 receptors is still at an early stage. Recently, several groups, including our own, have begun to address this subject: in this brief review, we discuss some of these effects and speculate on likely function of extracellular nucleotides in the ...
M A, Bailey, K A, Hillman, R J, Unwin
openaire +2 more sources
Trends in Pharmacological Sciences, 2006
Purinergic signalling has been implicated in many biological processes, and ATP and other extracellular nucleotides might have therapeutic potential in the treatment of cancer by signalling through P2 receptors. Different P2 receptor subtypes have been identified in a variety of different cancer types, in both primary samples of human cancer tissue and
Nicholas, White, Geoffrey, Burnstock
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Purinergic signalling has been implicated in many biological processes, and ATP and other extracellular nucleotides might have therapeutic potential in the treatment of cancer by signalling through P2 receptors. Different P2 receptor subtypes have been identified in a variety of different cancer types, in both primary samples of human cancer tissue and
Nicholas, White, Geoffrey, Burnstock
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Seminars in Thrombosis and Hemostasis, 2005
The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition, recent evidence suggests that vesicular trafficking is an important pathway of nucleotide release.
Boeynaems, Jean-Marie +3 more
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The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition, recent evidence suggests that vesicular trafficking is an important pathway of nucleotide release.
Boeynaems, Jean-Marie +3 more
openaire +3 more sources
The P2 Receptors in Platelet Function
Seminars in Thrombosis and Hemostasis, 2005After vessel wall injury, platelets adhere to the exposed subendothelium, are activated, and release mediators such as thromboxane A (2) (TXA (2)) and nucleotides stored at very high concentration in the so-called dense granules. Among other soluble agents, released nucleotides act in a positive feedback mechanism to cause further platelet activation ...
Hechler, Beatrice +2 more
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The Platelet P2 Receptors in Thrombosis
Seminars in Thrombosis and Hemostasis, 2005Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) play a crucial role in hemostasis and thrombosis, and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X (1) and the two G protein-coupled P2Y (1) and P2Y (12) ADP receptors selectively contribute to platelet aggregation.
Gachet, Christian, Hechler, Beatrice
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P2 receptors: intracellular signaling
Pflügers Archiv - European Journal of Physiology, 2006P2 receptors for extracellular nucleotides are divided into two categories: the ion channel receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal transduction appears to be relatively simple. Upon activation by extracellular ATP, a channel comprised of P2X receptor subunits opens and allows cations to move across the ...
Laurie, Erb +3 more
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Renal P2 receptors and hypertension
Acta Physiologica, 2014AbstractThe regulation of extracellular fluid volume is a key component of blood pressure homeostasis. Long‐term blood pressure is stabilized by the acute pressure natriuresis response by which changes in renal perfusion pressure evoke corresponding changes in renal sodium excretion.
R. I. Menzies, R. J. Unwin, M. A. Bailey
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