Results 261 to 270 of about 204,366 (349)

The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis

, 2009
Nadia D’Ambrosi, Pamela Finocchi, Savina Apolloni, Mauro Cozzolino, Alberto Ferri, Valeria Padovano, Grazia Pietrini, Maria Teresa Carrı̀, Cinzia Volonté   +8 more
openalex   +2 more sources

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

Annals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff, Alexander Schulz, Christian Hagel, Robert Büttner, Michael Reuter, Waylan K. Bessler, D. Wade Clapp, Helen Morrison   +7 more
wiley   +1 more source

Transforming RNA Degradation into Accurate RNA Detection: RNase I–Assisted Rolling Circle Amplification for Clinical Samples

Angewandte Chemie, EarlyView.
Here, we transform this otherwise destructive enzymatic activity into a powerful diagnostic advantage through an RNase I–assisted rolling circle amplification (RI‐RCA) strategy. By integrating controlled RNase I–mediated RNA digestion with circular DNA templates, this approach enables direct and highly sensitive detection of target RNA sequences. Using
Amal Mathai, Cheng‐Yu Lee, Zijie Zhang, Jimmy Gu, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

Roles in physiology and disease of the inositol phosphatase synaptojanin 1. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids
De Camilli P.
europepmc   +1 more source

Individualized Treatment in Distal and Medium Vessel Occlusion Stroke Using a Validated Explainable Counterfactual Treatment Estimation Model

Annals of Neurology, EarlyView.
Objective The optimal treatment for distal medium vessel occlusion (DMVO) stroke remains uncertain, and evidence comparing endovascular therapy (EVT) with medical management (MM) is limited. We aimed to develop and validate a predictive modeling tool to assess individual treatment benefit in DMVO stroke using explainable counterfactual treatment ...
Mohamed F. Doheim, Mahmoud H. Mohammaden, Hend Abdelhamid, Marta Olive‐Gadea, Marc Rodrigo‐Gisbert, Manuel Requena, Johanna T. Fifi, James E. Siegler, Santiago Ortega‐Gutierrez, Mohamad Abdalkader, Ali Alaraj, Wei Hu, Thanh N. Nguyen, Diogo C. Haussen, Raul G. Nogueira   +14 more
wiley   +1 more source

Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease. [PDF]

Clin Sci (Lond)
Cheng Z, Montgomery MK.
europepmc   +1 more source

Generation of Induced Pluripotent Stem Cells and Neuroepithelial Stem Cells from a Family with the Pathogenic Variant p.Q337X in Progranulin. [PDF]

Int J Mol Sci
Gaweda-Walerych K, Figarski A, Gawlik-Zawiślak S, Woźniak M, Chołoniewska A, Mierzwa N, Lutostańska E, Szymanowski J, Wężyk M.   +8 more
europepmc   +1 more source

Clinical and Immunological Impact of JAK Inhibition in Concurrent Down Syndrome and STAT1 Gain of Function. [PDF]

J Clin Immunol
Blanco-Lobo P, Gilabert-Prieto P, de Felipe B, Moreno-Fuentes D, Guisado Hernández P, Ortiz-Ramírez A, Mensa-Vilaró A, Aróstegui JI, Palmou N, Velasco Gonzalez V, Deyà Martinez Á, Ramakers J, Ivorra-Cortés J, Roca C, Cordero E, Guillen I, Valerdiz Menéndez N, Lucena JM, Gaboli M, Olbrich P, Neth O.   +20 more
europepmc   +1 more source

Blockade of P2 Nucleotide Receptors After Spinal Cord Injury Reduced the Gliotic Response and Spared Tissue

, 2011
Ana E. Rodríguez‐Zayas, Aranza I. Torrado, Odrick R. Rosas, José M. Santiago, Johnny D. Figueroa, Jorge D. Miranda   +5 more
openalex   +2 more sources

A computational framework for the investigation of phosphoinositide regulation. [PDF]

PLoS Comput Biol
Cheung HYF, Tantiwong C, Kale D, Gibbins JM, Watson SP, Heemskerk JWM, Sickmann A, Ahrends R, Dunster JL.   +8 more
europepmc   +1 more source