Results 191 to 200 of about 135,603 (303)

Purine and Pyrimidine (P2) Receptors as Drug Targets

, 2002
Kenneth A. Jacobson, Michael F. Jarvis, Michael Williams   +2 more
openalex   +2 more sources

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

Advanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
wiley   +1 more source

P2‐023: Vitamin D receptor polymorphisms and Alzheimer disease [PDF]

, 2015
Ging‐Yuek Robin Hsiung, Alice Fok, Jacqueline A. Pettersen   +2 more
openalex   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

P2 receptors signaling in the esophagus: from inflammation to cancer. [PDF]

Purinergic Signal
Zaparte A, Cruz FF, de Souza JB, Morrone FB.   +3 more
europepmc   +1 more source

Mathematical Prediction for Geometry‐Mediated Cell 3D In‐Growth on Bone Tissue Engineering Scaffolds

Advanced Science, EarlyView.
This study identifies a fundamental pore size dependent pattern of three dimensional bone marrow derived mesenchymal stem cell (BMSC) infiltration within porous scaffolds, where small pores promote horizontal cellular bridging and large pores facilitate vertical migration.
Xiang Gao, Zhijun Yu, Yu Yan, Jiamin Ding, Wangsiyuan Teng, Chenhe Zhou, Minjun Yao, Wenkan Zhang, Shenzhi Zhao, Fangqian Wang, Zhenxuan Shao, Jinfeng Zhou, Xiaoyong Wu, Chengcheng Yu, Liang Chen, Xiaoqiang Jin   +15 more
wiley   +1 more source

Temporal mRNA Expression of Purinergic P2 Receptors in the Brain Following Cerebral Ischemia and Reperfusion: Similarities and Distinct Variations Between Rats and Mice. [PDF]

Int J Mol Sci
Challa SR, Levingston H, Fornal CA, Baker IM, Boston J, Shanthappa N, Unnam P, Klopfenstein JD, Veeravalli KK.   +8 more
europepmc   +1 more source

Medicinal chemistry of P2 and adenosine receptors: Common scaffolds adapted for multiple targets

, 2020
Kenneth A. Jacobson, Adriaan P. IJzerman, Christa E. Müller   +2 more
openalex   +2 more sources

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

P2-126: The role of pax transcription factors in lung carcinogenesis: relationship to c-Met receptor tyrosine kinase [PDF]

, 2007
Rajani Kanteti, Vidya Nallasura, Cindy Wang, Rabia Hasan, Sivakumar Loganathan, Ramasamy Jagadeeswaran, Aliya N. Husain, Deborah Lang, Ravi Salgia   +8 more
openalex   +1 more source