Results 201 to 210 of about 60,226 (246)
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Renal P2 receptors and hypertension
Acta Physiologica, 2014AbstractThe regulation of extracellular fluid volume is a key component of blood pressure homeostasis. Long‐term blood pressure is stabilized by the acute pressure natriuresis response by which changes in renal perfusion pressure evoke corresponding changes in renal sodium excretion.
R. I. Menzies, R. J. Unwin, M. A. Bailey
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The P2 Receptors in Platelet Function
Seminars in Thrombosis and Hemostasis, 2005After vessel wall injury, platelets adhere to the exposed subendothelium, are activated, and release mediators such as thromboxane A (2) (TXA (2)) and nucleotides stored at very high concentration in the so-called dense granules. Among other soluble agents, released nucleotides act in a positive feedback mechanism to cause further platelet activation ...
Béatrice, Hechler +2 more
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Current Topics in Medicinal Chemistry, 2004
The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor subtypes is described. This is followed by a summary of what is known of the distribution and roles of these receptor subtypes. Potential therapeutic targets of purinoceptors are considered, including those involved in cardiovascular, nervous, respiratory ...
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The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor subtypes is described. This is followed by a summary of what is known of the distribution and roles of these receptor subtypes. Potential therapeutic targets of purinoceptors are considered, including those involved in cardiovascular, nervous, respiratory ...
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P2 receptors and neuronal injury
Pflügers Archiv - European Journal of Physiology, 2006Extracellular adenosine 5'-triphosphate (ATP) was proposed to be an activity-dependent signaling molecule that regulates glia-glia and glia-neuron communications. ATP is a neurotransmitter of its own right and, in addition, a cotransmitter of other classical transmitters such as glutamate or GABA.
Heike, Franke +2 more
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The Platelet P2 Receptors in Thrombosis
Seminars in Thrombosis and Hemostasis, 2005Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) play a crucial role in hemostasis and thrombosis, and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X (1) and the two G protein-coupled P2Y (1) and P2Y (12) ADP receptors selectively contribute to platelet aggregation.
Christian, Gachet, Béatrice, Hechler
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2017
Adenine nucleotides (ADP and ATP) play crucial roles in the physiological process of primary hemostasis and in the development and extension of arterial thrombosis. They act on platelets through three distinct P2 receptors: the P2Y1 and P2Y12 receptors, which are G protein-coupled ADP receptors and the P2X1 receptor, a ligand-gated cation channel ...
Béatrice Hechler, Christian Gachet
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Adenine nucleotides (ADP and ATP) play crucial roles in the physiological process of primary hemostasis and in the development and extension of arterial thrombosis. They act on platelets through three distinct P2 receptors: the P2Y1 and P2Y12 receptors, which are G protein-coupled ADP receptors and the P2X1 receptor, a ligand-gated cation channel ...
Béatrice Hechler, Christian Gachet
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Extracellular ATP, P2 receptors, and inflammation
Drug Development Research, 2003AbstractOver the past few years, P2 receptors have emerged as new potential players in the early phases of inflammation in their function of chemotactic receptors, triggers of proinflammatory cytokine release, and cytotoxic molecules. However, more recent data suggest that the role of P2 receptors in immunity is much more widespread and touches the ...
Di Virgilio F. +6 more
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Journal of the Autonomic Nervous System, 2000
Although the emphasis in ATP research has been on postjunctional receptors, there is also evidence for presynaptic receptors regulating transmitter release in the autonomic nervous system. Recent work has attempted to identify similar mechanisms in the central nervous system.
T W, Stone +3 more
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Although the emphasis in ATP research has been on postjunctional receptors, there is also evidence for presynaptic receptors regulating transmitter release in the autonomic nervous system. Recent work has attempted to identify similar mechanisms in the central nervous system.
T W, Stone +3 more
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P2-Pyrimidinergic Receptors and Their Ligands
Current Pharmaceutical Design, 2002Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y(2), P2Y(4), P2Y(6) and P2Y(14).
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P2 receptors in the murine gastrointestinal tract
Neuropharmacology, 2002The actions of adenosine, adenosine 5'-triphosphate (ATP), 2-methylthio adenosine diphosphate ADP (2-MeSADP), 2-methylthio ATP (2-MeSATP), alpha,beta-methylene ATP (alpha,beta-meATP) and uridine triphosphate (UTP) on isolated segments of mouse stomach (fundus), duodenum, ileum and colon were investigated. The localization of P2Y(1), P2Y(2), P2Y(4), P2X(
GIARONI, CRISTINA +7 more
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