Results 211 to 220 of about 60,226 (246)

The platelet P2 receptors in inflammation

Hämostaseologie, 2015
SummaryIn addition to their well characterized and established role in haemostasis and thrombosis, platelets contribute to the pathogenesis of inflammation. Adenine nucleotides are signalling molecules that regulate the function of virtually every cell in the body, by interacting with P2 receptors.
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Adventures in the pharmacological analysis of P2 receptors

Journal of the Autonomic Nervous System, 2000
The pharmacological classification of P2 receptors owes its origin to the pioneering efforts of Geoff Burnstock and those who followed him, research that was conducted primarily in physiological experimental systems. Over recent years, the techniques of molecular biology have been increasingly applied in the study of P2 receptors while, at the same ...
Fagura, M.S., Jarvis, Gavin, Dougall, I.G., Leff, P.   +3 more
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The platelet P2 receptors in arterial thrombosis

Blood Cells, Molecules, and Diseases, 2006
ADP and ATP play a crucial role in hemostasis and thrombosis and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X1 and the two G protein-coupled P2Y1 and P2Y12 ADP receptors selectively contribute to platelet aggregation.
Christian, Gachet, Catherine, Léon, Béatrice, Hechler   +2 more
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Salivary Gland P2 Nucleotide Receptors

Critical Reviews in Oral Biology & Medicine, 1999
The effects of ATP on salivary glands have been recognized since 1982. Functional and pharmacological studies of the P2 nucleotide receptors that mediate the effects of ATP and other extracellular nucleotides have been supported by the cloning of receptor cDNAs, by the expression of the receptor proteins, and by the identification in salivary gland ...
J T, Turner, L A, Landon, S J, Gibbons, B R, Talamo   +3 more
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P2 receptors meet the immune system

Trends in Pharmacological Sciences, 2001
Abstract The 1st International Workshop on Nucleotides and their Receptors in the Immune System was held on 8–10 September 2000 at the University of Ferrara, Ferrara, Italy.
DI VIRGILIO, Francesco, BOREA, Pier Andrea, ILLES P.   +2 more
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P2 Purinergic Receptors in Tumor Immunity

Cancer Research
Abstract P2 purinergic receptors are activated by extracellular ATP and other nucleotides released during cellular stress, hypoxia, or inflammation, serving as key mediators of intercellular communication. In cancer, they rapidly accumulate in the tumor microenvironment following cell death or metabolic stress.
Xin Wang, Shu-Heng Jiang, Mingyue Ma, Shuqi Cai, Dong Song, Bing Han   +5 more
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REGULATION OF PLATELET FUNCTIONS BY P2 RECEPTORS

Annual Review of Pharmacology and Toxicology, 2006
▪ Abstract  The main role of blood platelets is to ensure primary hemostasis, which is the maintenance of vessel integrity and cessation of bleeding upon injury. While playing a major part in acute arterial thrombosis, platelets are also involved in inflammation, atherosclerosis, and angiogenesis. ADP and ATP play a crucial role in platelet activation,
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The P2 Nucleotide Receptors

1998
Part I. Historical Perspectives of P2 Nucleotide Receptors. History of Extracellular Nucleotides and Their Receptors, G. Burnstock. Part II. Pharmacological and Molecular Characterization of P2 Nucleotide Receptors. P2x Receptors: Cloned and Expressed, R. J. Evans, A. Surprenant, and R. A. North.
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The discovery and development of P2 receptor subtypes

Journal of the Autonomic Nervous System, 2000
Extracellular purine and pyrimidine nucleotides modulate cellular activity by acting at P2 receptors. The first receptor to be identified was the P(2)-purinoceptor, which was characterised and named in 1978. In the 1980s this site was subdivided into P(2X) and P(2Y) purinoceptors on the basis of pharmacological criteria in functional studies on native ...
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Subtypes of P2 Receptors in Rat Neuromuscular Junction

Bulletin of Experimental Biology and Medicine
At the neuromuscular junction, ATP and its metabolite adenosine regulate the release of acetylcholine by activating purinergic receptors (P2), thereby regulating the function of skeletal muscles under normal and pathological conditions. The presence of P2 receptors in the neuromuscular junction was assessed immunohistochemically on sections of m ...
A E, Khairullin, A N, Khabibrakhmanov, D V, Efimova, D V, Samigullin, S N, Grishin, M A, Mukhamedyarov, A U, Ziganshin   +6 more
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