Results 191 to 200 of about 60,424 (245)

Resveratrol as a potential natural compound to ameliorate cognitive impairment in aluminum-exposed mice: impacts on behavior, purinergic system, and brain inflammation. [PDF]

Metab Brain Dis
Visentini AE, Reichert KP, Schetinger MRC, Bottari NB, Miron VV, Castro MFV, da Silveira MV, Assmann CE, Schirmann AA, Morsch VMM.   +9 more
europepmc   +1 more source

Nucleotide signaling in neutrophils: a key player in cancer dynamics. [PDF]

Purinergic Signal
da Silva JLG, Sévigny J, Leal DBR.
europepmc   +1 more source

Chronic spontaneous urticaria treatments and purinergic signaling: a therapeutic possibility. [PDF]

J Mol Med (Berl)
Fontana M, Simões JLB, de Carvalho Braga G, Fontana M, Filho JCM, Bagatini MD.   +5 more
europepmc   +1 more source

Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.

Am J Physiol Cell Physiol, 2013
Ilatovskaya DV, Palygin O, Levchenko V, Staruschenko A.   +3 more
europepmc   +1 more source

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Ocular P2 receptors and glaucoma

Neuropharmacology, 2023
Adenosine triphosphate (ATP), an energy source currency in cells, is released or leaked to the extracellular space under both physiological and pathological conditions. Extracellular ATP functions as an intercellular signaling molecule through activation of purinergic P2 receptors.
Youichi, Shinozaki, Kozo, Saito, Kenji, Kashiwagi, Schuichi, Koizumi   +3 more
openaire   +2 more sources

P2 receptors in the kidney

Journal of the Autonomic Nervous System, 2000
Our understanding of the actions of extracellular ATP in controlling kidney function via stimulation of P2 receptors is still at an early stage. Recently, several groups, including our own, have begun to address this subject: in this brief review, we discuss some of these effects and speculate on likely function of extracellular nucleotides in the ...
M A, Bailey, K A, Hillman, R J, Unwin
openaire   +2 more sources

P2 receptors and cancer

Trends in Pharmacological Sciences, 2006
Purinergic signalling has been implicated in many biological processes, and ATP and other extracellular nucleotides might have therapeutic potential in the treatment of cancer by signalling through P2 receptors. Different P2 receptor subtypes have been identified in a variety of different cancer types, in both primary samples of human cancer tissue and
Nicholas, White, Geoffrey, Burnstock
openaire   +2 more sources

Overview of the P2 Receptors

Seminars in Thrombosis and Hemostasis, 2005
The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition, recent evidence suggests that vesicular trafficking is an important pathway of nucleotide release.
Boeynaems, Jean-Marie, Communi, Didier, Suarez Gonzalez, Nathalie, Robaye, Bernard   +3 more
openaire   +3 more sources

The P2 Receptors in Platelet Function

Seminars in Thrombosis and Hemostasis, 2005
After vessel wall injury, platelets adhere to the exposed subendothelium, are activated, and release mediators such as thromboxane A (2) (TXA (2)) and nucleotides stored at very high concentration in the so-called dense granules. Among other soluble agents, released nucleotides act in a positive feedback mechanism to cause further platelet activation ...
Hechler, Beatrice, Cattaneo, M, Gachet, Christian   +2 more
openaire   +3 more sources

The Platelet P2 Receptors in Thrombosis

Seminars in Thrombosis and Hemostasis, 2005
Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) play a crucial role in hemostasis and thrombosis, and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X (1) and the two G protein-coupled P2Y (1) and P2Y (12) ADP receptors selectively contribute to platelet aggregation.
Gachet, Christian, Hechler, Beatrice
openaire   +3 more sources