Results 171 to 180 of about 130,183 (288)

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Purinergic signaling in dengue infection: modulation of P2 receptors as a potential therapeutic strategy. [PDF]

Purinergic Signal
de Melo VC, de Oliveira KI, Kipper M, Bagatini MD, da Silva GB.   +4 more
europepmc   +1 more source

A High‐Precision Dynamic Movement Recognition Algorithm Using Multimodal Biological Signals for Human–Machine Interaction

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This article describes a multimodal fusion data acquisition and processing system about electromyography for dynamic movement recognition and bioelectrical impedance for key posture recognition. In addition, a new dynamic–static fusion algorithm strategy is designed.
Chenhao Cao, Gang Ma, Zelin Chen, Yiming Ouyang, Hu Jin, Shiwu Zhang   +5 more
wiley   +1 more source

Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors. [PDF]

Purinergic Signal
Chaves MM, Carvalho-Barbosa N, Savio LEB, Coutinho-Silva R.   +3 more
europepmc   +1 more source

Material‐Based Intelligence: Autonomous Adaptation and Embodied Computation in Physical Substrates

Advanced Intelligent Systems, EarlyView.
This perspective formulates a unifying framework for Material‐Based Intelligence (MBI), defining the physical requirements for materials to achieve embodied action, active memory and embodied information processing through intrinsic nonequilibrium dynamics. The design of intelligent materials often draws parallels with the complex adaptive behaviors of
Vladimir A. Baulin, Rudolf M. Füchslin, Achille Giacometti, Helmut Hauser, Marco Werner   +4 more
wiley   +1 more source

Climate change and perennial crop production: Evidence of yield impact and adaptation in California

American Journal of Agricultural Economics, EarlyView.
Abstract Perennial crops are economically important. They contribute to food security, providing essential nutrients that are often lacking in annual crops, and provide additional environmental benefits compared with annual crops. Despite their importance, empirical research on the impacts of climate change and adaptation on perennial crops remains ...
Yuanyuan Wen, Wei Zhang, Julian M. Alston   +2 more
wiley   +1 more source

Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation

Angewandte Chemie, EarlyView.
CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova, Manisha B. Walunj, Claudia Höbartner   +2 more
wiley   +2 more sources

P2 receptors signaling in the esophagus: from inflammation to cancer. [PDF]

Purinergic Signal
Zaparte A, Cruz FF, de Souza JB, Morrone FB.   +3 more
europepmc   +1 more source

Clinical, Behavioral and Neuroradiological Phenotype in an Italian Cohort of Patients With Xia Gibbs Syndrome: A Multicenter Cross‐Sectional Study and Systematic Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous variants in the AHDC1 gene are associated with Xia Gibbs Syndrome (XGS), a genetic disorder with a highly variable phenotype. Cognitive impairment, motor delay, language delay, neonatal hypotonia, and sleep apnea are considered “cardinal” signs of the disease.
Giulia Cinelli, Stefania Della Vecchia, Patrizia Bergonzini, Elisa Caramaschi, Elisabetta Spezia, Claudia Parenti, Simona Filomena Madeo, Laura Lucaccioni, Cavalleri Francesca, Marisa Pugliese, Federico Raviglione, Clara Colonna, Olga Calabrese, Ilaria Stanghellini, Maria Carmen Marongiu, Enrico Biagioni, Anna Rita Ferrari, Roberta Battini, Lorenzo Iughetti   +18 more
wiley   +1 more source

Complications after medullary thyroid carcinoma surgery: multicentre study of the SQRTPA and EUROCRINE® databases

BJS (British Journal of Surgery), EarlyView., 2020
This study investigated postoperative complications after surgery for medullary thyroid carcinoma (MTC) in Europe. Hypoparathyroidism, recurrent laryngeal nerve palsy and bleeding requiring reoperation occurred in 170 (26·2 per cent), 62 (13·7 per cent) and 17 (2·6 per cent) patients respectively.
D.‐J. van Beek, M. Almquist, A. O. Bergenfelz, T. J. Musholt, E. Nordenström, on behalf of the EUROCRINE® Council, M. Almquist, M. Barczynski, L. Brunaud, T. Clerici, M. H. Hansen, M. Iacobone, Ö. Makay, F. F. Palazzo, N. Muñoz‐Pérez, M. Raffaelli, P. Riss, S. van Slycke, M. R. Vriens   +18 more
wiley   +1 more source