Results 51 to 60 of about 39,255 (248)
Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]
, 2002 Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R. +4 more
core +1 more source
Energy Conversion and Management: X, 2023 For achieving a carbon–neutral energy system, economical flexibility mechanisms are crucial to accommodate intermittent and decentralized renewable energy sources. Power-to-X (P2X) is a promising technology for this purpose.
Hiroaki Onodera +2 more
doaj
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino +8 more
wiley +1 more source
Emerging key roles for P2X receptors in the kidney [PDF]
, 2013 P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E. +3 more
core +2 more sources
Point Mutation in the Mouse P2X Receptor Affects Intercellular Calcium Waves in Astrocytes
ASN Neuro, 2009 Purinergic P2 receptors and gap junctions are two groups of proteins involved in the transmission of ICWs (intercellular calcium waves) between astrocytes.
Sylvia O Suadicani +3 more
doaj +1 more source
Cancer Communications, EarlyView.Abstract Background Radiotherapy (RT) is a key treatment modality in cancer therapy, utilizing high‐energy radiation to directly kill tumor cells. Recent research has increasingly highlighted RT's potential to indirectly enhance antitumor immunity. However, this immune activation alone often fails to generate sustained systemic antitumor responses.
Xuejiao Han +11 more
wiley +1 more source
P2X Receptors as Drug Targets [PDF]
Molecular Pharmacology, 2013 The study of P2X receptors has long been handicapped by a poverty of small-molecule tools that serve as selective agonists and antagonists. There has been progress, particularly in the past 10 years, as cell-based high-throughput screening methods were applied, together with large chemical libraries.
R. Alan North, Michael F. Jarvis
openaire +3 more sources
Allosteric Control of Gating and Kinetics at P2X₄ Receptor Channels [PDF]
, 1999 The CNS abundantly expresses P2X receptor channels for ATP; of these the most widespread in the brain is the P2X₄ channel. We show that ivermectin (IVM) is a specific positive allosteric effector of heterologously expressed P2X₄ and possibly of ...
Dunwiddie, Thomas V. +4 more
core
Particle Kinematics in Horava-Lifshitz Gravity [PDF]
, 2009 We study the deformed kinematics of point particles in the Horava theory of gravity. This is achieved by considering particles as the optical limit of fields with a generalized Klein-Gordon action.
A Kehagias +30 more
core +2 more sources
PRIMITIVE ATP-ACTIVATED P2X RECEPTORS: DISCOVERY, FUNCTION AND PHARMACOLOGY
Frontiers in Cellular Neuroscience, 2013 Adenosine 5-triphosphate (ATP) is omnipresent in biology. It is therefore no surprise that organisms have evolved multifaceted roles for ATP, exploiting its abundance and restriction of passive diffusion across biological membranes.
Samuel J Fountain
doaj +1 more source