Results 51 to 60 of about 19,677 (253)

Point Mutation in the Mouse P2X Receptor Affects Intercellular Calcium Waves in Astrocytes

ASN Neuro, 2009
Purinergic P2 receptors and gap junctions are two groups of proteins involved in the transmission of ICWs (intercellular calcium waves) between astrocytes.
Sylvia O Suadicani, Rodolfo Iglesias, David C Spray, Eliana Scemes   +3 more
doaj   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

PRIMITIVE ATP-ACTIVATED P2X RECEPTORS: DISCOVERY, FUNCTION AND PHARMACOLOGY

Frontiers in Cellular Neuroscience, 2013
Adenosine 5-triphosphate (ATP) is omnipresent in biology. It is therefore no surprise that organisms have evolved multifaceted roles for ATP, exploiting its abundance and restriction of passive diffusion across biological membranes.
Samuel J Fountain
doaj   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Familial hemiplegic migraine Ca_V2.1 channel mutation R192Q enhances ATP-gated P2X₃ receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

Molecular Pain, 2010
Background The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of voltage-gated P/Q Ca2+ channels (Cav2.1), is associated with familial hemiplegic migraine-1.
Nair Asha, Simonetti Manuela, Birsa Nicol, Ferrari Michel D, van den Maagdenberg Arn MJM, Giniatullin Rashid, Nistri Andrea, Fabbretti Elsa   +7 more
doaj   +1 more source

TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder

Scientific Reports, 2018
Both TRPV1 and P2X receptors present on bladder sensory nerve fibres have been implicated in mechanosensation during bladder filling. The aim of this study was to determine possible interactions between these receptors in modulating afferent nerve ...
L. Grundy, D. Daly, C. Chapple, D. Grundy, R. Chess-Williams   +4 more
semanticscholar   +1 more source

New Insights Into Permeation of Large Cations Through ATP-Gated P2X Receptors

Frontiers in Molecular Neuroscience, 2018
The permeability of large cations through the P2X pore has remained arguably the most controversial and complicated topic in P2X-related research, with the emergence of conflicting studies on the existence, mechanism and physiological relevance of a so ...
Laurie Peverini, Juline Beudez, Kate Dunning, T. Chataigneau, T. Grutter   +4 more
semanticscholar   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Extracellular ATP and the P2X₇ receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis

Journal of Neuroinflammation, 2010
Background During pathology of the nervous system, increased extracellular ATP acts both as a cytotoxic factor and pro-inflammatory mediator through P2X7 receptors. In animal models of amyotrophic lateral sclerosis (ALS), astrocytes expressing superoxide
Peluffo Hugo, Gandelman Mandi, Beckman Joseph S, Cassina Patricia, Barbeito Luis   +4 more
doaj   +1 more source

Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection. [PDF]

PLoS ONE, 2012
Acute viral infection causes damages to the host due to uncontrolled viral replication but even replication deficient viral vectors can induce systemic inflammatory responses.
Benjamin H Lee, David M Hwang, Nades Palaniyar, Sergio Grinstein, Dana J Philpott, Jim Hu   +5 more
doaj   +1 more source