Results 11 to 20 of about 11,033 (176)
Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors [PDF]
Neural Plasticity, 2017 Communication between neuronal and glial cells is important for neural plasticity. P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia.
Eric Boué-Grabot, Yuriy Pankratov
doaj +2 more sources
The trafficking and targeting of P2X receptors [PDF]
Frontiers in Cellular Neuroscience, 2013 The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Ruth Dorothy Murrell-Lagnado +1 more
doaj +2 more sources
P2X receptors as drug targets. [PDF]
Mol Pharmacol, 2013 The study of P2X receptors has long been handicapped by a poverty of small-molecule tools that serve as selective agonists and antagonists. There has been progress, particularly in the past 10 years, as cell-based high-throughput screening methods were applied, together with large chemical libraries.
North RA, Jarvis MF.
europepmc +4 more sources
Direct observation of ATP-induced conformational changes in single P2X(4) receptors. [PDF]
PLoS Biology, 2009 The ATP-gated P2X(4) receptor is a cation channel, which is important in various pathophysiological events. The architecture of the P2X(4) receptor in the activated state and how to change its structure in response to ATP binding are not fully understood.
Youichi Shinozaki +5 more
doaj +1 more source
ATP signaling in the integrative neural center of Aplysia californica
Scientific Reports, 2021 ATP and its ionotropic P2X receptors are components of the most ancient signaling system. However, little is known about the distribution and function of purinergic transmission in invertebrates.
János Györi +3 more
doaj +1 more source
Molecules, 2022 Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato +9 more
doaj +1 more source
Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats
Molecular Pain, 2006 Extracellular ATP is known to mediate synaptic transmission as a neurotransmitter or a neuromodulator via ionotropic P2X and metabotropic P2Y receptors.
Satoh Masamichi +4 more
doaj +1 more source
Virology Journal, 2011 Hepatitis C virus (HCV) is a major health problem in developing countries including Pakistan. Chronic HCV infection results in progressive liver disease including fibrosis, cirrhosis, insulin resistance and eventually hepatocellular carcinoma (HCC ...
Fatima Kaneez +8 more
doaj +1 more source
P2X receptors in neuroglia [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractDifferent types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in ...
Verkhratsky, A. +3 more
openaire +3 more sources
Introduction and perspective, historical note
Frontiers in Cellular Neuroscience, 2013 P2 nucleotide receptors were proposed to consist of two subfamilies based on pharmacology in 1985, named P2X and P2Y receptors. Later, this was confirmed following cloning of the receptors for nucleotides and studies of transduction mechanisms in the ...
Geoffrey eBurnstock
doaj +1 more source