Results 21 to 30 of about 11,033 (176)

Research progress in the role of P2X receptors in oral maxillofacial pain

口腔疾病防治, 2018
Oral maxillofacial pain is one of the most common symptoms that greatly influences patients′ quality of life. Infectious diseases, nerve injuries and tumors in the oromaxillofacial region can cause facial pain.
HE Lingkun, XIONG Wei
doaj   +1 more source

Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease

Molecular Neurodegeneration, 2011
Background Previous studies indicate a role of P2X7 receptors in processes that lead to neuronal death. The main objective of our study was to examine whether genetic deletion or pharmacological blockade of P2X7 receptors influenced dopaminergic cell ...
Kittel Ágnes, Madarász Emilia, Gölöncsér Flóra, Csölle Cecilia, Baranyi Mária, Hracskó Zsuzsanna, Sperlágh Beáta   +6 more
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Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin

Molecular Pain, 2006
Background Cultured sensory neurons are a common experimental model to elucidate the molecular mechanisms of pain transduction typically involving activation of ATP-sensitive P2X or capsaicin-sensitive TRPV1 receptors.
Giniatullin Rashid, Nistri Andrea, Zweyer Marina, D'Arco Marianna, Fabbro Alessandra, Simonetti Manuela, Fabbretti Elsa   +6 more
doaj   +1 more source

Subunit Arrangement in P2X Receptors [PDF]

The Journal of Neuroscience, 2003
ATP-gated ionotropic receptors (P2X receptors) are distributed widely in the nervous system. For example, a hetero-oligomeric receptor containing both P2X2and P2X3subunits is involved in primary afferent sensation. Each subunit has two membrane-spanning domains.
Jiang, Lin Hua, Kim, Miran, Spelta, Valeria, Bo, Xuenong, Surprenant, Annmarie, North, R. Ala   +5 more
openaire   +3 more sources

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells

BMC Immunology, 2004
Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and G protein-coupled P2Y receptors.
Bengtsson Anders, Jacobsen Sten Eirik W, Wang Lingwei, Erlinge David   +3 more
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Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines

BMC Immunology, 2006
Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo, Kong In Deok, Park Kyu Sang, Lee Dong Hyeon, Han Bok Ghee   +4 more
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PRIMITIVE ATP-ACTIVATED P2X RECEPTORS: DISCOVERY, FUNCTION AND PHARMACOLOGY

Frontiers in Cellular Neuroscience, 2013
Adenosine 5-triphosphate (ATP) is omnipresent in biology. It is therefore no surprise that organisms have evolved multifaceted roles for ATP, exploiting its abundance and restriction of passive diffusion across biological membranes.
Samuel J Fountain
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Familial hemiplegic migraine Ca_V2.1 channel mutation R192Q enhances ATP-gated P2X₃ receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

Molecular Pain, 2010
Background The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of voltage-gated P/Q Ca2+ channels (Cav2.1), is associated with familial hemiplegic migraine-1.
Nair Asha, Simonetti Manuela, Birsa Nicol, Ferrari Michel D, van den Maagdenberg Arn MJM, Giniatullin Rashid, Nistri Andrea, Fabbretti Elsa   +7 more
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Antidepressants inhibit P2X₄ receptor function: a possible involvement in neuropathic pain relief

Molecular Pain, 2009
Background Neuropathic pain is characterized by pain hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to known treatments such as non-steroidal anti-inflammatory drugs or even opioids.
Tozaki-Saitoh Hidetoshi, Tsuda Makoto, Yamashita Tomohiro, Imai Toshiyasu, Nagata Kenichiro, Inoue Kazuhide   +5 more
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A P2X receptor-mediated nociceptive afferent pathway to lamina I of the spinal cord

Molecular Pain, 2005
Of the six lamina regions in the dorsal horn of the spinal cord, lamina I is a major sensory region involved in nociceptive transmission under both physiological and pathological conditions.
Gu Jianguo G, Chen Meng
doaj   +1 more source