Results 51 to 60 of about 11,033 (176)

Pharmacological manipulation of the immediate effects of spinal trauma in neonatal rats reveals a crucial role for TRPV4 receptors

The Journal of Physiology, EarlyView.
Abstract figure legend A, schematic illustration of the ventral aspect of an ex vivo preparation of the entire CNS from a neonatal rat subjected to a calibrated thoracic impact. The trauma induced a large depolarising injury potential (DIP, black trace) recorded from the L5 ventral root (VRrL5), which was markedly reduced by transient receptor ...
Atiyeh Mohammadshirazi, Caterina Ciani, Francesca Emma Mongelli, Rashid Giniatullin, Carmen Falcone, Giuliano Taccola   +5 more
wiley   +1 more source

Flow cytometry identifies an early stage of platelet apoptosis produced by agonists of the P2X1 and P2X7 receptors

Platelets, 2022
Platelets express P2X1 receptors and our data also show the expression of P2X7 receptors. We studied the role of both receptors in platelet apoptosis by incubation of PRP with P2X agonists, then centrifuged to remove viable platelets, and analyzed the ...
Joelyn Wong, Ben J. Gu, Harry Teoh, Malgorzata Krupa, Mastura Monif, Mark Slee, James S. Wiley   +6 more
doaj   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Bradykinin Contributes to Sympathetic and Pressor Responses Evoked by Activation of Skeletal Muscle Afferents P2X in Heart Failure

Cellular Physiology and Biochemistry, 2016
Background/Aims: Published data suggest that purinergic P2X receptors of muscle afferent nerves contribute to the enhanced sympathetic nervous activity (SNA) and blood pressure (BP) responses during static exercise in heart failure (HF).
Jihong Xing, Jianhua Li
doaj   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Manipulation of P2X Receptor Activities by Light Stimulation

Mediators of Inflammation, 2016
P2X receptors are involved in amplification of inflammatory responses in peripheral nociceptive fibers and in mediating pain-related signals to the CNS.
Sang Seong Kim
doaj   +1 more source

Evolution of P2X receptors [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractPurines appear to be the most primitive and widespread chemical messengers in all kingdoms of the Domain Eucarya. There is evidence for purinergic signaling in plants, invertebrates, and lower vertebrates from protozoa to birds. Much is based on pharmacological studies, but important recent papers have utilized the techniques of molecular ...
Burnstock, G., Verkhratsky, A.
openaire   +1 more source

pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Albrecht Schwab, Micol Rugi, Pawel Swietach, Wiktoria Błaszczak, Ivana Novak, Ganga Deshar, Stine Falsig Pedersen, Renata Ialchina, Albin Sandelin, Jiayi Yao, Stephan J. Reshkin, Rosa A. Cardone, Tiago M. A. Carvalho, Annarosa Arcangeli, Rayhana Bouazzi, Franco N. D'Alessandro, Natalia Prevarskaya, Madelaine M. Audero, Halima Ouadid‐Ahidouch, Julie Schnipper, Luis A. Pardo, Xiaoyi Shi, Frauke Alves, Jakub Mitręga, Anna Trauzold, Sofie E. Hagelund, György Panyi, Marco Cozzolino, Clemens M. W. G. Löwik, Laura Mezzanotte, Roisin McMorrow, Andreas Pahl, Torsten Hechler, Elena Papacharisi, Alessandra Fiorio Pla, Ildiko Szabo, Verena Hofschröer, Zoltán Pethő   +37 more
wiley   +1 more source

Pharmacology of P2X receptors [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011
AbstractP2X receptors are ligand‐gated cation channels that mediate many of the extracellular actions of adenosine 5′‐triphosphate (ATP). The genes encoding seven different P2X subunits, P2X1–7, have been cloned and when expressed alone all P2X subunits form functional receptors, except P2X6, which usually only assembles in a heteromeric form. Subunits
Nawazish‐i‐Husain Syed, Charles Kennedy   +1 more
openaire   +1 more source

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
P2X7R regulates the nucleoplasmic translocation of HuR, thereby enhancing the stability of the E3 ubiquitin ligase TRIM26. TRIM26 directly binds to NR4A1 and promotes its ubiquitination, thereby suppressing mitophagy and increasing reactive oxygen species (ROS) production.
Yixin Zhou, Xin Zhong, Zhijie Mao, Yunxuan Chen, Jincheng Xing, Jiaxu Shen, Wenli Zhang, Ji Zhang, Jiaxuan Mei, Zhentong Yang, Zhuoqun Wang, Bozhi Ye, Jiahui Lin, Yonghua Wang, Zhouqing Huang   +14 more
wiley   +1 more source