Results 101 to 110 of about 21,110 (244)

Corneal Re-epithelialization Stimulated by Diadenosine Polyphosphates Recruits RhoA/ROCK and ERK1/2 Pathways [PDF]

, 2008
Purpose. To investigate the role of ERK1/2 and RhoA/ROCK intracellular pathways in the modification of corneal re-epithelialization when stimulated by the diadenosine polyphosphates Ap4A and Ap3A. Methods.
Crooke, Almudena, Guzmán Aránguez, Ana Isabel, Mediero Muñoz, Aránzazu, Peral Cerdá, Assumpta, Pintor, Jesús   +4 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source

Selective stimulation of catecholamine release from bovine adrenal chromaffin cells by an ionotropic purinergic receptor sensitive to 2-methylthio ATP

BMC Neuroscience, 2007
Background 2-Methylthioadenosine 5'-triphosphate (2-MeSATP), formerly regarded as a specific P2Y (metabotropic) purinergic receptor agonist, stimulates Ca2+ influx and evokes catecholamine release from adrenal chromaffin cells.
Castro Enrique, Tomé Ângelo R, Santos Rosa M, Rosário Luís M   +3 more
doaj   +1 more source

Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y₁₂ Antagonists in a cAMP- and Calcium-Dependent Manner

Pharmaceuticals, 2020
We have shown previously that platelet activity can be lowered through the simultaneous inhibition of P2Y12 receptor and activation of adenosine receptors (AR).
Nina Wolska, Hassan Kassassir, Boguslawa Luzak, Cezary Watala, Marcin Rozalski   +4 more
doaj   +1 more source

Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma [PDF]

, 2017
Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Fonseca Vázquez, Begoña, Gómez Villafuertes, María Rosa, Martínez Águila, Alejandro, Miras Portugal, María Teresa, Pintor, Jesús, Pérez de Lara, María Jesús   +5 more
core   +2 more sources

Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines

BMC Immunology, 2006
Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo, Kong In Deok, Park Kyu Sang, Lee Dong Hyeon, Han Bok Ghee   +4 more
doaj   +1 more source

P2X7 receptors induce degranulation in human mast cells. [PDF]

, 2016
Mast cells play important roles in host defence against pathogens, as well as being a key effector cell in diseases with an allergic basis such as asthma and an increasing list of other chronic inflammatory conditions.
A Lundequist, A Surprenant, AG Driver, AM Gilfillan, AS Kirshenbaum, AW Hauswirth, B Hechler, C Feng, CE Owen, D Ferrari, DM Manthei, E Shigetomi, Elizabeth P. Seward, ES Schulman, F Jacob, F Virgilio Di, G Barbara, G Buell, G Burnstock, G Burnstock, H Saito, J Capite Di, JM Brown, JP Bennett, K Mulryan, K Wareham, Kathryn J. Wareham, M Idzko, M Idzko, M Vig, MA McCloskey, MG Rolf, N Sudo, OK Basoglu, PE Tatham, R Dahlquist, R Dahlquist, RC Wykes, RJ Evans, SR Holdsworth, TM Egan, Y Kurashima, Y Osipchuk, ZG Gao   +43 more
core   +1 more source

Ticagrelor inverse agonist activity at the P2Y₁₂ receptor is non‐reversible versus its endogenous agonist adenosine 5´‐diphosphate [PDF]

, 2023
Jawad S. Khalil, Tudor Dimofte, Timothy K. Roberts, M. J. Keith, Kumuthu S. Amaradasa, Matthew S. Hindle, Sukhinder Bancroft, James L. Hutchinson, Khalid M. Naseem, Tom Johnson, Stuart J. Mundell   +10 more
openalex   +1 more source

P2X7 Receptor Mediated Increase In Cell Membrane Permeability

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2018
Purinergic receptors consist of two main families; P2X and P2Y. P2Y receptors are G protein coupled receptors (GPCR), whereas P2X receptors are non-selective cation channels. P2X7 receptors which is a member of P2X receptors, have been found myriad types
Șerife Cankurtaran-Sayar, Kemal Sayar
doaj   +1 more source

Purinergic Signaling in Mast Cell Degranulation and Asthma

Frontiers in Pharmacology, 2017
Mast cells are responsible for the majority of allergic conditions. It was originally thought that almost all allergic events were mediated directly only via the high-affinity immunoglobulin E receptors.
Zhan-Guo Gao, Kenneth A. Jacobson
doaj   +1 more source