Results 101 to 110 of about 20,383 (265)
Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]
, 2002 The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas
core +1 more source
Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado–Joseph Disease
Annals of Neurology, Volume 98, Issue 1, Page 107-119, July 2025.Objective An abundance of select transcripts and proteins has been found to be dysregulated in blood samples of Machado–Joseph disease (MJD) carriers. Here, we aimed to: (1) identify blood transcriptional changes as potential biomarkers of MJD; (2) correlate levels of differentially expressed blood transcripts with MJD carriers features; and (3 ...
Ana F. Ferreira +10 more
wiley +1 more source
Transcriptional and translational differences of microglia from male and female brains [PDF]
, 2019 Sex differences in brain structure and function are of substantial scientific interest because of sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a common denominator of many of these diseases and thus microglia
Güneykaya, Dilansu
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BMC Research Notes, 2010 Background Purines such as adenosine and ATP are now generally recognized as the regulators of many physiological functions, such as neurotransmission, pain, cardiac function, and immune responses.
Suzuki Tokiko +2 more
doaj +1 more source
ATP Mediates Pyroptosis in the Intestinal Mucosal System During Colitis
Journal of Cellular Physiology, Volume 240, Issue 7, July 2025.ABSTRACT Damage‐associated molecular patterns (DAMPs) are molecules released from damaged or dying cells that contribute to inflammation and cell death. Extracellular ATP, a type of DAMP, has been studied primarily in the context of pyroptosis in monocytes.
Sihyun Jeong +6 more
wiley +1 more source
P2Y11 receptors : properties, distribution and functions [PDF]
, 2017 The P2Y11 receptor is a G protein-coupled receptor that is stimulated by endogenous purine nucleotides, particularly ATP. Amongst P2Y receptors it has several unique properties; 1) it is the only human P2Y receptor gene that contains an intron in the ...
Kennedy, Charles
core +1 more source
Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]
, 2011 Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core +1 more source
Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]
, 2012 Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz +60 more
core +2 more sources
BMC Neuroscience, 2007 Background 2-Methylthioadenosine 5'-triphosphate (2-MeSATP), formerly regarded as a specific P2Y (metabotropic) purinergic receptor agonist, stimulates Ca2+ influx and evokes catecholamine release from adrenal chromaffin cells.
Castro Enrique +3 more
doaj +1 more source