Results 11 to 20 of about 20,383 (265)
Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques. [PDF]
PLoS ONE, 2010 BACKGROUND: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors.
Reyhan Nergiz-Unal +8 more
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Sustained Release of Prostaglandin E2 in Fibroblasts Expressing Ectopically Cyclooxygenase 2 Impairs P2Y-Dependent Ca2+-Mobilization [PDF]
Mediators of Inflammation, 2014 The nucleotide uridine trisphosphate (UTP) released to the extracellular milieu acts as a signaling molecule via activation of specific pyrimidine receptors (P2Y). P2Y receptors are G protein-coupled receptors expressed in many cell types.
María Pimentel-Santillana +6 more
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P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells [PDF]
BMC Immunology, 2004 Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and G protein-coupled P2Y receptors.
Bengtsson Anders +3 more
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P2Y receptors in Alzheimer's disease. [PDF]
Biol Cell, 2015 Alzheimer's disease (AD) is the most common cause of dementia, affecting more than 10% of people over the age of 65. Age is the greatest risk factor for AD, although a combination of genetic, lifestyle and environmental factors also contribute to disease development.
Erb L, Cao C, Ajit D, Weisman GA.
europepmc +5 more sources
Dual Effect of Nucleotides on P2Y Receptors [PDF]
IUBMB Life, 2000 The interaction of ADP, 2MeSADP, and ADPbetaS with the adenine nucleotide receptor P2Y1 in the hP2Y1-1321N1 cell line and of UDP with a receptor or receptors recognizing pyrimidine nucleotides in NG108-15 cells was studied over a wide range ofligand concentrations.
Katrin Sak, Eric A. Barnard, Jaak Järv
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P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. [PDF]
J Neurosci, 2016 Activation of visceral nociceptors by inflammatory mediators contributes to visceral hypersensitivity and abdominal pain associated with many gastrointestinal disorders.
Hockley JR +11 more
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P2Y receptors and kidney function. [PDF]
Wiley Interdiscip Rev Membr Transp Signal, 2012 AbstractCellular release of nucleotides is of physiological importance to regulate and maintain cell function and integrity. Also in the tubular and collecting duct system of the kidney, nucleotides are released in response to changes in cell volume or luminal flow rate and act in a paracrine and autocrine way on basolateral and luminal P2Y receptors ...
Vallon V, Stockand J, Rieg T.
europepmc +5 more sources
P2Y receptors and pain transmission [PDF]
Purinergic Signalling, 2004 It is widely accepted that the most important ATP receptors involved in pain transmission belong to the P2X(3) and P2X(2/3) subtypes, selectively expressed in small diameter dorsal root ganglion (DRG) neurons. However, several types of the metabotropic ATP (P2Y) receptors have also been found in primary afferent neurons; P2Y(1) and P2Y(2) receptors are
Peter Illes, Zoltan Gerevich
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P2Y receptors in neurogenesis [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractG protein‐coupled P2Y receptors (Rs) regulate the function of embryonic and adult neural precursor cells (NPCs) which have the capacity to regenerate and give rise to cells belonging to all three major linages of the nervous system: neurons, oligodendrocytes and astrocytes.
Patrizia Rubini +2 more
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Life, 2021 Extracellular ATP in the tumor microenvironment exhibits either pro- or antitumor effect via interaction with P2Y receptors, but the intracellular signaling and functional roles of P2Y receptors in oral squamous cell carcinoma (OSCC) are unclear.
Chia Chih Lau +5 more
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