Results 11 to 20 of about 21,110 (244)

Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]

Respiratory Research, 2005
Background Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Gurney Alison M, Chootip Krongkarn, Kennedy Charles   +2 more
doaj   +2 more sources

P2Y receptors and kidney function. [PDF]

Wiley Interdiscip Rev Membr Transp Signal, 2012
AbstractCellular release of nucleotides is of physiological importance to regulate and maintain cell function and integrity. Also in the tubular and collecting duct system of the kidney, nucleotides are released in response to changes in cell volume or luminal flow rate and act in a paracrine and autocrine way on basolateral and luminal P2Y receptors ...
Vallon V, Stockand J, Rieg T.
europepmc   +4 more sources

Recommended tool compounds and drugs for blocking P2X and P2Y receptors. [PDF]

Purinergic Signal, 2021
Müller CE, Namasivayam V.
europepmc   +3 more sources

P2Y receptors in lung inflammation [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractNucleotides, e.g., adenosine‐5′‐triphosphate (ATP), can be released into the extracellular space under acute or chronic inflammatory conditions and have been shown to serve as potent immunomodulators or danger signals involved in the initiation and maintenance of immune responses.
Tobias Müller, Marco Idzko
openaire   +2 more sources

Control of Macrophage Inflammation by P2Y Purinergic Receptors

Cells, 2021
Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity.
Dominik Klaver, Martin Thurnher
doaj   +1 more source

NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female

Biomolecules, 2021
Nucleotides released by smooth muscle cells (SMCs) and by innervating nerve terminals activate specific P2 receptors and modulate bladder contraction. We hypothesized that cell surface enzymes regulate SMC contraction in mice bladder by controlling the ...
Romuald Brice Babou Kammoe, Gilles Kauffenstein, Julie Pelletier, Bernard Robaye, Jean Sévigny   +4 more
doaj   +1 more source

Pharmacological Nature of the Purinergic P2Y Receptor Subtypes That Participate in the Blood Pressure Changes Produced by ADPβS in Rats

Pharmaceuticals, 2023
Purine nucleosides (adenosine) and nucleotides such as adenosine mono/di/triphosphate (AMP/ADP/ATP) may produce complex cardiovascular responses. For example, adenosine-5′-(β-thio)-diphosphate (ADPβS; a stable synthetic analogue of ADP) can induce ...
Roberto C. Silva-Velasco, Belinda Villanueva-Castillo, Kristian A. Haanes, Antoinette MaassenVanDenBrink, Carlos M. Villalón   +4 more
doaj   +1 more source

Extracellular ATP Induced S-Phase Cell Cycle Arrest via P2Y Receptor-Activated ERK Signaling in Poorly Differentiated Oral Squamous Cell Carcinoma SAS Cells

Life, 2021
Extracellular ATP in the tumor microenvironment exhibits either pro- or antitumor effect via interaction with P2Y receptors, but the intracellular signaling and functional roles of P2Y receptors in oral squamous cell carcinoma (OSCC) are unclear.
Chia Chih Lau, Amnani Aminuddin, Kok Meng Chan, Ian C. Paterson, Lok Mun Law, Pei Yuen Ng   +5 more
doaj   +1 more source

Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair. [PDF]

Purinergic Signal, 2023
Povo-Retana A, Sánchez-García S, Alvarez-Lucena C, Landauro-Vera R, Prieto P, Delgado C, Martín-Sanz P, Boscá L.   +7 more
europepmc   +3 more sources

Molecular and Pharmacological Evidence for the Expression of Multiple Functional P2 Purinergic Receptors in Human Adipocytes

Molecules, 2022
Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato, Francesca Favaretto, Marnie Granzotto, Marika Crescenzi, Alessandra Boscaro, Angelo Di Vincenzo, Federico Capone, Edoardo Dalla Nora, Eva Zabeo, Roberto Vettor   +9 more
doaj   +1 more source