Results 51 to 60 of about 20,383 (265)

Transmission to interneurons is via slow excitatory synaptic potentials mediated by P2Y(1) receptors during descending inhibition in guinea-pig ileum. [PDF]

PLoS ONE, 2013
BACKGROUND: The nature of synaptic transmission at functionally distinct synapses in intestinal reflex pathways has not been fully identified. In this study, we investigated whether transmission between interneurons in the descending inhibitory pathway ...
Peter D J Thornton, Rachel M Gwynne, Darren J McMillan, Joel C Bornstein   +3 more
doaj   +1 more source

Building Immunocompetent Cerebral Organoids From a Developmental Perspective

Glia, EarlyView.
Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statistical analysis to help develop standardized protocols. ABSTRACT Cerebral organoids derived from human induced pluripotent stem cells (iPSCs) are increasingly ...
Xabier Cuesta‐Puente, Marco Gonzalez‐Dominguez, Marta Pereira‐Iglesias, Nerea Perez‐Arriazu, Patricia Villegas‐Zafra, Paula Ramos‐Gonzalez, Fabio Cavaliere, Nora Bengoa‐Vergniory, Amanda Sierra   +8 more
wiley   +1 more source

Anti-platelet therapy: ADP receptor antagonists. [PDF]

, 2011
The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S, Wijeyeratne, YD
core   +2 more sources

NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca²⁺-mobilization/influx and cortisol secretion. [PDF]

PLoS ONE, 2013
Purinergic receptor expression and involvement in steroidogenesis were examined in NCI-H295R (H295R), a human adrenal cortex cell line which expresses all the key enzymes necessary for steroidogenesis. mRNA/protein for multiple P1 (A(2A) and A(2B)), P2X (
Haruhisa Nishi, Hirokazu Arai, Toshihiko Momiyama   +2 more
doaj   +1 more source

Effect of P2Y12 Inhibitors on Major Adverse Cardiovascular Events After Coronary Artery Bypass Graft Surgery: A Population‐Based Cohort Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Background Patients who undergo coronary artery bypass graft (CABG) surgery remain at high risk for major adverse cardiovascular events (MACE) despite contemporary preventive pharmacotherapy. Although commonly used in practice, it is uncertain whether P2Y12 inhibitors reduce MACE in patients post‐CABG surgery.
Arden R. Barry, Hamed Helisaz, Abdollah Safari, Peter S. Loewen   +3 more
wiley   +1 more source

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death [PDF]

, 2010
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication.
A Gartland, A Hoebertz, A Surprenant, A Trautmann, A Verkhratsky, AN Drury, AV Gourine, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, B Hechler, B Johansson, B Vandewalle, BB Fredholm, BB Fredholm, BS Khakh, BS Khakh, C Giaume, C Ledent, C Ponnamperuma, CA Salvatore, CH Fiske, CI Seye, CJ Dixon, D Erlinge, DA Cockayne, E Ghanem, E Rapaport, EB Gonzales, EW Inscho, EW Sutherland, F Di Virgilio, F Di Virgilio, F Di Virgilio, F Lippman, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Clark, H Franke, H Woodward, H Zimmermann, HZ Ke, I Bar, IF Gow, IP Chessell, J Korcok, J Li, J Nilsson, JA Burgers, JA Sim, JE Wilson, JF Chen, JF Chen, JL Madara, JM Armstrong, JM Sanz, JT Neary, K Inoue, K Inoue, K Inoue, K Lohmann, K Mulryan, K Wirkner, K Yamamoto, KA Moore, L Gimenez-Llort, L Li, M Horckmans, M Naassila, M Ryten, M Shabbir, M Shabbir, M Shabbir, M Sugioka, M Tsuda, MJ Bours, MJ Ludlow, MM Waldrop, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Meyer, MW Grol, MW Verghese, MY Avila, N Lenain, N Panupinthu, N White, N White, N White, PB Conley, R Brown, R Janssens, RA North, RA North, RJ Cerniway, S Kirischuk, S Kirischuk, S Pochet, S Ryzhov, SD Ohlendorff, SJ Fountain, SJ Fountain, SL Tilley, T Kawate, TE Finger, U Groschel-Stewart, U Groschel-Stewart, UK Hanisch, V Ralevic, V Ralevic, V Souslova, VL Cressman, X Bian, X Hua, Y Guo, Y Pankratov, Y Pankratov, Y Pankratov, Y Pankratov, YD Bogdanov, Z Xiang, Z Zhao   +139 more
core   +2 more sources

Purinergic Receptors in Spinal Cord-Derived Ependymal Stem/Progenitor Cells and Their Potential Role in Cell-Based Therapy for Spinal Cord Injury

Cell Transplantation, 2015
Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination ...
Rosa Gómez-Villafuertes Ph.D., Francisco Javier Rodríguez-Jiménez, Ana Alastrue-Agudo, Miodrag Stojkovic, María Teresa Miras-Portugal, Victoria Moreno-Manzano   +5 more
doaj   +1 more source

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, EarlyView.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]

, 2014
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter, Cauwels, Anje, Rogge, Elke, Shiva, S, Vandendriessche, Benjamin   +4 more
core   +1 more source

Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior

Molecular Pain, 2010
Background Investigations of nucleotide signaling in nociception to date have focused on actions of adenosine triphosphate (ATP). Both ATP-gated ion channels (P2X receptors) and G protein-coupled (P2Y) receptors contribute to nociceptive signaling in ...
Molliver Derek C, Malin Sacha A
doaj   +1 more source