Results 61 to 70 of about 20,383 (265)

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Physiological Electrical Signals Promote Chain Migration of Neuroblasts by Up-Regulating P2Y1 Purinergic Receptors and Enhancing Cell Adhesion [PDF]

, 2014
Acknowledgments This work was supported by a grant from NHS Grampian. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the ...
Cao, Lin, Ching, Jared, McCaig, Colin D, Pu, Jin, Scott, Roderick H   +4 more
core   +2 more sources

P2Y receptors in GtoPdb v.2021.3

IUPHAR/BPS Guide to Pharmacology CITE, 2021
P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [3, 5, 192]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use ...
Gary A. Weisman, Vera Ralevic, Maria Teresa Miras-Portugal, Christa E. Müller, Davide Lecca, Brian F. King, Charles Kennedy, Kenneth A. Jacobson, Kazu Inoue, Robert G. Humphries, Rebecca Hills, Christian Gachet, Marta Fumagalli, Stefania Ceruti, Geoffrey Burnstock, José L. Boyer, Jean-Marie Boeynaems, Maria-Pia Abbracchio   +17 more
openaire   +3 more sources

Adenosine Receptor Agonists Exhibit Anti-Platelet Effects and the Potential to Overcome Resistance to P2Y₁₂ Receptor Antagonists

Molecules, 2019
Large inter-individual variation in platelet response to endogenous agonists and pharmacological agents, including resistance to antiplatelet therapy, prompts a search for novel platelet inhibitors and development new antithrombotic strategies.
Nina Wolska, Magdalena Boncler, Dawid Polak, Joanna Wzorek, Tomasz Przygodzki, Magdalena Gapinska, Cezary Watala, Marcin Rozalski   +7 more
doaj   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, EarlyView.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank, Lalo, Ulyana, North, R. Alan, Pankratov, Yuriy, Rossner, Moritz J., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), Wichert, Sven P.   +6 more
core   +1 more source

Emodin Inhibits ATP-Induced Proliferation and Migration by Suppressing P2Y Receptors in Human Lung Adenocarcinoma Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Extracellular ATP performs multiple important functions via activation of P2 receptors on the cell surface. P2Y receptors play critical roles in ATP evoked response in human lung adenocarcinoma cells (A549 cells).
Xia Wang, Long Li, Ruijuan Guan, Danian Zhu, Nana Song, Linlin Shen   +5 more
doaj   +1 more source

Microglial Activation and Inflammatory Responses in Parkinson's Disease Models Are Attenuated by TRPM2 Depletion

Glia, Volume 73, Issue 10, Page 2035-2056, October 2025.
Main Points Trpm2 partial and complete knockout reduce neuroinflammation in male and female mice. Microglial morphological changes are not found in Trpm2 knockout 6‐OHDA‐induced mice. TRPM2 is involved in microglial phagocytosis and IL1β, IL6, and iNOS expression. ABSTRACT Inflammation, and particularly microglial cells, has become a central feature in
Ana Flávia F. Ferreira, Zhong‐Ping Feng, Hong‐Shuo Sun, Luiz Roberto G. Britto   +3 more
wiley   +1 more source

TheP2Yreceptors and thrombosis [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2013
Blood platelets play a key role in arterial thrombosis which is one of the leading causes of mortality in western countries. They may also be involved in the pathogenesis of deep vein thrombosis. Adenosine 5′‐diphosphate (ADP) is one of the most important mediators of platelet activation.
Christian Gachet, Béatrice Hechler
openaire   +2 more sources

ARF6-dependent regulation of P2Y receptor traffic and function in human platelets.

PLoS ONE, 2012
Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors, the P2Y(1) and P2Y(12) purinoceptors. Recently, we demonstrated that P2Y(1) and P2Y(12) purinoceptor activities are
Venkateswarlu Kanamarlapudi, Sian E Owens, Keya Saha, Robert J Pope, Stuart J Mundell   +4 more
doaj   +1 more source