Results 171 to 180 of about 25,694 (216)

Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice. [PDF]

Mol Psychiatry
Huang M, Ye H, Xu Y, Xie J, Wang X, Luo Y, Liu P, Ma X, Zhang S, Jiang B, Ye WC, Peng Y, Shi L.   +12 more
europepmc   +1 more source

Specific Glutamylation Patterns of the Cytoskeleton Confer Neuroresistance to Lobe X of the Cerebellum in a Model of Childhood-Onset Neurodegeneration with Cerebellar Atrophy. [PDF]

Int J Mol Sci
Hernández-Pérez C, Calderón-García AA, Pérez-Boyero D, González-Núñez V, Weruaga E, Díaz D.   +5 more
europepmc   +1 more source

A congenic C57BL/6J rd1 mouse model for retinal degeneration research. [PDF]

Exp Eye Res
Chandler LC, Gardner A, Cepko CL.
europepmc   +1 more source

Erratum in: Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells. [PDF]

Invest Ophthalmol Vis Sci
europepmc   +1 more source

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Regulation of membrane association and kinase activity of Cdk5–p35 by phosphorylation of p35

Journal of Neuroscience Research, 2007
AbstractAlthough protein kinase Cdk5–p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult rat brains.
Ko, Sato, Ying-Shan, Zhu, Taro, Saito, Kensuke, Yotsumoto, Akiko, Asada, Masato, Hasegawa, Shin-ichi, Hisanaga   +6 more
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Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35

Molecular Brain Research, 2002
Cyclin-dependent kinase 5 (cdk5) is involved in the development of the nervous system and neuronal process outgrowth, and it regulates several intracellular processes including cytoskeletal dynamics. Dysregulation of cdk5 has been implicated in many disorders of the nervous system.
Petri, Kerokoski, Tiina, Suuronen, Antero, Salminen, Hilkka, Soininen, Tuula, Pirttilä   +4 more
openaire   +2 more sources

Crystallization and low-resolution structure of an effector-caspase/P35 complex: similarities and differences to an initiator-caspase/P35 complex

Acta Crystallographica Section D: Biological Crystallography, 2002
The aspartate-specific caspases play a pivotal role in the execution of programmed cell death and therefore constitute important targets for the control of apoptosis. Upon ectopic expression, baculovirus P35 inhibits apoptosis in phylogenetically diverse organisms by suppressing the proteolytic activity of the cellular caspases in a cleavage-dependent ...
Michael J Eddins, Andrew J Fisher
exaly   +3 more sources

P35

Oral Diseases, 2005
Withdrawn/Transferred ...
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Neurotoxicity induces cleavage of p35 to p25 by calpain

Nature, 2000
Cyclin-dependent kinase 5 (cdk5) and its neuron-specific activator p35 are required for neurite outgrowth and cortical lamination. Proteolytic cleavage of p35 produces p25, which accumulates in the brains of patients with Alzheimer's disease. Conversion of p35 to p25 causes prolonged activation and mislocalization of cdk5.
Young T Kwon, Junmin Peng, Robert M Friedlander   +2 more
exaly   +3 more sources