Results 181 to 190 of about 25,694 (216)
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ANKRA2 interacts with p35 and is a substrate for Cdk5/p35
2014Cdk5 is a serine/threonine kinase that plays a pivotal role in neural development. Activation of Cdk5 requires its association with its activator, p35 or p39. More than forty proteins have been identified as the substrates for Cdk5. By phosphorylating these diverse cellular targets, Cdk5 plays a multifunctional role in nervous system including neurite ...
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The role of the Cdk5-p35 kinase in neuronal development
European Journal of Biochemistry, 2001Cyclin‐dependent kinase 5 (Cdk5) plays a key role in proper development of the nervous system. To be activated, Cdk5 associates with regulatory subunits not related to cyclins, such as p35 (the regulatory subunit of Cdk5). In this article, we review some of the experimental evidence supporting a central role for the Cdk5/p35 kinase in neuronal ...
G, Paglini, A, Cáceres
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Biochemistry, 1998
The anti-apoptotic protein p35 from baculovirus is thought to prevent the suicidal response of infected insect cells by inhibiting caspases. Ectopic expression of p35 in a number of transgenic animals or cell lines is also anti-apoptotic, giving rise to the hypothesis that the protein is a general inhibitor of caspases. We have verified this hypothesis
Q, Zhou +6 more
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The anti-apoptotic protein p35 from baculovirus is thought to prevent the suicidal response of infected insect cells by inhibiting caspases. Ectopic expression of p35 in a number of transgenic animals or cell lines is also anti-apoptotic, giving rise to the hypothesis that the protein is a general inhibitor of caspases. We have verified this hypothesis
Q, Zhou +6 more
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Callosal axon guidance defects in p35?/? mice
The Journal of Comparative Neurology, 1999Mice lacking p35, an activator of cdk5 in the central nervous system (CNS), exhibit defects in a variety of CNS structures, most prominently characterized by a disruption in the laminar structure of the neocortex (Chae et al., 1997). In addition, alterations of certain axonal fiber tracts are found in the cortex of p35 mutant mice.
Y T, Kwon, L H, Tsai, J E, Crandall
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Peripeti
Peripeti 35 © Peripeti og forfatterne Temaredaktion Solveig Gade, Johan Holm Mortensen, Storm Møller Madsen, Anika Marschall, Thomas Rosen dal Nielsen. Redaktion Janicke Branth, Erik Exe Christoffersen, Solveig Daugaard, Michael Eigtved, Solveig Gade, Falk Heinrich, Storm Møller Madsen, Johan Holm Mortensen, Thomas Rosendal Nielsen (ansv ...
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Peripeti 35 © Peripeti og forfatterne Temaredaktion Solveig Gade, Johan Holm Mortensen, Storm Møller Madsen, Anika Marschall, Thomas Rosen dal Nielsen. Redaktion Janicke Branth, Erik Exe Christoffersen, Solveig Daugaard, Michael Eigtved, Solveig Gade, Falk Heinrich, Storm Møller Madsen, Johan Holm Mortensen, Thomas Rosendal Nielsen (ansv ...
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Activity and regulation of p35 / Cdk5 kinase complex
2000Publisher Summary This chapter discusses the activity and regulation of p35/Cdk5 kinase complex. The importance of the p35/Cdk5 kinase in cortical development has been shown by mouse knockout experiments. In neurons, both p35 and Cdk5 localize to the actin-rich peripheral lamellipodia of growing axons.
M, Nikolic, L H, Tsai
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