Results 221 to 230 of about 327,693 (283)

Astragaloside IV inhibits MAPK pathway and promotes mitochondrial autophagy in rats with heart failure. [PDF]

Korean J Physiol Pharmacol
Wang Y, Chen Y, Li T, Zhong P, Wang Q.
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Tanshinone IIA prevents septicemia acute kidney injury via regulating the DUSP10/JNK/P38/NLRP3 pathway. [PDF]

Am J Transl Res
Wen D, Deng Q, Zeng Y, Li L, Yang X, Chen Q, Yan Y, Lv J.   +7 more
europepmc   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics

Rare Metals, EarlyView.
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu, Shao‐Sheng Jia, Rong‐Bang Sun, Tong Zhang, Ling‐Chuang Bai, Di Mei, Shi‐Jie Zhu, Lan Chen, Shao‐Kang Guan   +8 more
wiley   +1 more source

Caffeic acid phenethyl ester alleviates 1,2-dichloroethane-induced toxic cerebral edema: central and peripheral mechanisms. [PDF]

Front Pharmacol
Sun Y, Yin B, He S, Miao L, Yang J, Wang Y, Jin X.   +6 more
europepmc   +1 more source

Leveraging Viscosity to Unlock the Osteogenic Potential of BMP‐2 Mimetic DWIVA

Small, EarlyView.
Dynamic interfaces based on supported lipid bilayers demonstrate that the osteogenic potential of the BMP‐2 mimetic DWIVA can be harnessed by modulating substrate viscosity. This work highlights that the viscous properties of the cellular microenvironment play a crucial role in the mechanosensitive regulation of growth factor activity.
Finlay Cunniffe, Ziyuan Luo, Eva Barcelona‐Estaje, Eva Forrest, Manuel Salmeron‐Sanchez, Marco Cantini   +5 more
wiley   +1 more source

IKK2, calcium, MAP kinase, and PI3 kinase are required for exocytosis and interleukin-8 production in human mast cells stimulated by Trichomonas vaginalis-derived secretory products. [PDF]

Parasites Hosts Dis
Park SH, Lee YA, Shin MH.
europepmc   +1 more source

Spatiotemporal Co‐Delivery of Hydrogen and Magnesium via Microneedle Patches for Neuroinflammation Modulation After Spinal Cord Injury: A Multi‐Modal In Vivo Study

Small, EarlyView.
A spatiotemporal co‐delivery microneedle system (MN‐Mg) is developed for spinal cord injury repair. By generating hydrogen gas and magnesium ions in situ, this dual‐engine platform effectively scavenges ROS and modulates microglial polarization via the MAPK/AP‐1 signaling axis.
Haibo Wang, Yang Sun, Shiqi Wang, Wenbo Wang, Jincheng Tang, Ziang Li, Xinzhao Jiang, Liang Zhou, Jie Wu, Qiangqiang Guo, Yiwei Zhu, Yu Feng, Kun Xi, Liang Chen   +13 more
wiley   +1 more source

Melatonin attenuates glandular cystitis via modulation of THBS1 and TLR4/p38 MAPK/STAT3 signaling. [PDF]

Sci Rep
Chen B, Gong S, Zhang J, Zhang Y, Wang H.   +4 more
europepmc   +1 more source