Results 21 to 30 of about 205,636 (290)

p38 MAPK in MDS

Aging, 2015
Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic malignancies occurring mainly in the elderly and characterized by the defective production of mature blood cells. MDS subtypes can be classified as "low-risk" and "high-risk" syndromes on the basis of their risk of progression to acute leukemia.
Irene, Gañán-Gómez, Zachary S, Bohannan, Guillermo, Garcia-Manero   +2 more
openaire   +2 more sources

Impact of p38 MAP Kinase Inhibitors on LPS-Induced Release of TNF-α in Whole Blood and Primary Cells from Different Species

Cellular Physiology and Biochemistry, 2015
Background/Aims: Inhibition of p38 mitogen-activated protein kinase (p38 MAPK) is promising for the treatment of inflammatory disorders, however, the efficacy of p38 MAPK inhibitors in clinical trials is limited so far.
Sarah Fehr, Anke Unger, Elke Schaeffeler, Sonja Herrmann, Stefan Laufer, Matthias Schwab, Wofgang Albrecht   +6 more
doaj   +1 more source

Neurite Outgrowth of PC12 Mutant Cells Induced by Orange Oil and d-Limonene via the p38 MAPK Pathway [PDF]

, 2012
We studied the effects of natural essential oil on neurite outgrowth in PC12m3 neuronal cells to elucidate the mechanism underlying the action of the oils used in aromatherapy.
Hiragami, Fukumi, Kano, Yoshio, Kasanami, Yoshiko, Kawamura, Kenji, Motoda, Hirotoshi, Nagoshi, Megumi, Shinomiya, Misae, Tanida, Emiko   +7 more
core   +1 more source

Continuous Blood Purification Ameliorates Multiple Organ Failure Through Inhibiting the Activation of the P38 MAPK Signaling Pathway in a Rat Model

Kidney & Blood Pressure Research, 2018
Background/Aims: Multiple organ failure (MOF) is a primary threat to the survival of patients with systemic inflammation. Blood purification is employed in the treatment of MOF, as an artificial kidney or artificial liver.
Lan Ling, Qian-Kuan Wen, Shan-Hong Zhang, Li-Da Zhi, Hong Li, Gang Li, Wen-Jia Zhang   +6 more
doaj   +1 more source

p38 MAPK reins in right ventricular growth [PDF]

Journal of Clinical Investigation, 2020
The right ventricle (RV) is involved in systemic circulation in the fetal mammalian heart but quickly transitions to being solely responsible for pulmonary circulation after birth when the left ventricle (LV) becomes the systemic ventricle. To handle the increased workload, LV growth greatly outpaces that of the RV during postnatal stages. However, the
Tongbin Wu, Ju Chen
openaire   +4 more sources

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin‐induced apoptosis mediated by reactive oxygen species and JNK

EMBO Molecular Medicine, 2013
The p38 MAPK pathway is an important regulator of many cellular responses. It is well established that p38 MAPK signalling negatively regulates epithelial cell transformation, but enhanced p38 MAPK activity has been also correlated with bad clinical ...
Lorena Pereira, Ana Igea, Begoña Canovas, Ignacio Dolado, Angel R. Nebreda   +4 more
doaj   +1 more source

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]

, 2010
Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Acampora, Bialek, Bo Zhai, Despina Sitara, Dorothy Hu, El-Gharbawy, Jae-Hyuck Shim, Jin Mo Park, Jones, Karsenty, Laurie H. Glimcher, Lee, Matthew B. Greenblatt, Michael D. Schneider, Michelle Schweitzer, Min Xie, Mundlos, Raingeaud, Roger Davis, Roland Baron, Shim, Simon Arthur, Steven Gygi, Sutada Lotinun, Weiguo Zou, Yang, Yasuyo Sano   +26 more
core   +6 more sources

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]

, 2014
Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre, Antonescu, Bain, Boppart, Cancello, Cao, Carlson, Caroline P. Wheeler-Jones, Cazzolli, Chavez, Cleasby, Coll, Corraliza, de Alvaro, De Paepe, Devaraj, Diamond-Stanic, Dimopoulos, Elgazar-Carmon, Festa, Fink, Fujishiro, Gao, Griffin, Haversen, Hemi, Hevener, Hirabara, Hirosumi, Hoehn, Hommelberg, Hotamisligil, Hotamisligil, Hwang, Kadotani, Karten, Kewalramani, Kuma, Lee, Lee, Liang, Lumeng, Lumeng, Maekawa, Mark E. Cleasby, McCall, Nguyen, Nicola A. Talbot, Patel, Pillon, Pinnick, Plomgaard, Polkinghorne, Prieur, Samokhvalov, Schilling, Sell, Shi, Solinas, Storlien, Suganami, Tardif, Thong, Turner, Uysal, Varma, Weisberg, Yuan   +67 more
core   +2 more sources

The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons

eLife, 2016
Neurons are sensitive to low oxygen (hypoxia) and employ a conserved pathway to combat its effects. Here, we show that p38 MAP Kinase (MAPK) modulates this hypoxia response pathway in C. elegans.
Eun Chan Park, Christopher Rongo
doaj   +1 more source

Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection. [PDF]

, 2015
BackgroundFruit flies and mammals protect themselves against infection by mounting immune and metabolic responses that must be balanced against the metabolic needs of the pathogens.
Aguirre, Alejandro, Cheung, Kong, Drexler, Anna, Eigenheer, Richard, Giulivi, Cecilia, Glennon, Elizabeth KK, Klyver, John M, Lewis, Edwin E, Luckhart, Shirley, Napoli, Eleonora, Pakpour, Nazzy, Phinney, Brett S, Surachetpong, Win, Wang, Bo   +13 more
core   +1 more source