Results 1 to 10 of about 646,683 (270)

The Role of CaMK-II in the Development of Leukemia/Lymphoma in Danio Rerio [PDF]

, 2017
Acute lymphocytic leukemia (ALL) is a blood disorder characterized by aberrant proliferation of immature lymphocytes. ALL is the most common cancer in children and can result from external influences, such as radiation, or internal influences, such as ...
Mohammadi, Daniel
core   +1 more source

Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

Cell Reports
Summary: Tumor suppressor p53 has inherent propensities to self-associate, which can lead to oncogenic p53 aggregation. The genome caretaker 53BP1 interacts with p53, forms DNA damage-associated condensates, and has been implicated in p53 activation ...
Antonio Galarreta, Virginia Pasti, Julia Vornberger, Ralph Imhof, Mariano Oppikofer, Matthias Altmeyer   +5 more
doaj   +1 more source

Defeating Cytoplasmic Sequestration of p53 in Human Breast Cancer Cells; Is Mortalin Involved? [PDF]

, 2012
Cytoplasmic sequestration of p53, possibly caused by p53 interacting with mortalin, can prevent p53 from functioning in DNA repair and apoptosis, causing aberrant growth.
Yunes, Sarah
core   +1 more source

Opto-p53: A light-controllable activation of p53 signaling pathway

Cell Structure and Function
p53 protein, a crucial transcription factor in cellular responses to a wide variety of stress, regulates multiple target genes involved in tumor suppression, senescence induction, and metabolic functions.
Tatsuki Tsuruoka, Yuhei Goto, Kazuhiro Aoki   +2 more
doaj   +1 more source

Pregnane X receptor mitigates aristolochic acid-induced acute kidney injury via p53 ubiquitination. [PDF]

Ren Fail
Liu Q, Deng F, Chen A, Liu Y.
europepmc   +1 more source

Noc1 downregulation induces nucleolar stress and upregulates p53 isoforms, with a robust increase of the truncated p53E isoform in Drosophila wing discs. [PDF]

G3 (Bethesda)
Vutera Cuda A, Bajaj S, Manara V, Bellosta P.   +3 more
europepmc   +1 more source

Exploratory Proteomic Profiling Reveals Potential Mediators of 5-FU Response under p53 Deficiency in Colon Cancer Cells. [PDF]

Biomol Ther (Seoul)
Lee S, Lee J, Lee GS, Moon JH, Jung J.
europepmc   +1 more source

p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells. [PDF]

Elife
Kumar R, Couly S, Muys BR, Li XL, Grammatikakis I, Singh R, Guest M, Wen X, Tang W, Ambs S, Jenkins LM, Pehrsson EC, Chari R, Su TP, Lal A.   +14 more
europepmc   +1 more source

Tumor Suppressor p53 and MicroRNAs Interaction in Breast Cancer. [PDF]

Oncol Res
Luna MEV, Lourenço GJ, Carron J.
europepmc   +1 more source

TP53 Loss Fuels mTORC1 Activation and Autophagy Suppression to Drive Immune-Cold Colorectal Cancer. [PDF]

World J Oncol
Lee E, Al-Assi D, Rivera-Rueda R, Paul SS, Joy A.   +4 more
europepmc   +1 more source