Results 1 to 10 of about 905,362 (332)

Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]

PLoS ONE, 2010
The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Danupon Nantajit, Ming Fan, Nadire Duru, Yunfei Wen, John C Reed, Jian Jian Li   +5 more
doaj   +17 more sources

Live Or Let Die: The Cell'S Response To P53.

Nature Reviews. Cancer, 2002
Kh Vousden, Xin Lü
openalex   +2 more sources

Functional display of bioactive peptides on the vGFP scaffold

Scientific Reports, 2021
Grafting bioactive peptides into recipient protein scaffolds can often increase their activities by conferring enhanced stability and cellular longevity. Here, we describe use of vGFP as a novel scaffold to display peptides. vGFP comprises GFP fused to a
Sharon Min Qi Chee, Jantana Wongsantichon, Lau Sze Yi, Barindra Sana, Yuri Frosi, Robert C. Robinson, Farid J. Ghadessy   +6 more
doaj   +1 more source

Online academic satisfaction during the COVID-19 pandemic in medical students: role of sleep, psychological issues, college adjustment, and digital skills [version 3; peer review: 2 approved]

F1000Research, 2022
Background: The measures taken to contain the COVID-19 pandemic, led to significant changes in university education, resulting in the new normal standard of virtual teaching in many undergraduate medical schools worldwide.
Fiorella Hernandez, Josue F. Canaza, Salomón Huancahuire-Vega, Ricardo Rojas-Humpire, Sebastian A. Medina-Ramirez   +4 more
doaj   +1 more source

Changes in Eating Habits and Lifestyles in a Peruvian Population during Social Isolation for the COVID-19 Pandemic

Journal of Nutrition and Metabolism, 2021
Background. Peru has one of the highest infection and death rates in the world for the COVID-19 pandemic. The government implemented house confinement measures with probable consequences on lifestyle, particularly affecting eating habits, physical ...
Salomón Huancahuire-Vega, Edda E. Newball-Noriega, Ricardo Rojas-Humpire, Jacksaint Saintila, Mery Rodriguez-Vásquez, Percy. G. Ruiz-Mamani, Wilter C. Morales-García, Michael White   +7 more
doaj   +1 more source

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1:a novel anticancer small-molecule [PDF]

, 2015
Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of ...
Bessa, Cláudia, Bisio, Alessandra, Fernandes, João, Gomes, Célia, Gomes, Sara, Gonçalves, Jorge, Inga, Alberto, Monteiro, Ângelo, Pereira, Clara, Pereira, Nuno A.L., Queiroz, Glória, Raimundo, Liliana, Reis, Flávio, Santos, Maria M.M., Saraiva, Lucília, Soares, Joana   +15 more
core   +8 more sources

Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

Nature Communications, 2022
Approaches have been devised to increase the discovery rate of intrabodies but often these yield results that aren’t functional in cells. Here the authors engineer and optimise an autonomous and disulphide-free human VH domain for intracellular ...
Yuri Frosi, Yen-Chu Lin, Jiang Shimin, Siti Radhiah Ramlan, Kelly Hew, Alf Henrik Engman, Anil Pillai, Kit Yeung, Yue Xiang Cheng, Tobias Cornvik, Par Nordlund, Megan Goh, Dilraj Lama, Zachary P. Gates, Chandra S. Verma, Dawn Thean, David P. Lane, Ignacio Asial, Christopher J. Brown   +18 more
doaj   +1 more source

Targeting p53 pathways: mechanisms, structures and advances in therapy

Signal Transduction and Targeted Therapy, 2023
The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles ...
Haolan Wang, M. Guo, Hudie Wei, Yongheng Chen   +3 more
semanticscholar   +1 more source

Validación de un cuestionario que mide las percepciones del rol del profesional de enfermería comunitaria en Perú

Atención Primaria, 2022
Resumen: Objetivo: Elaborar una escala válida y fiable para medir el rol del profesional de enfermería en la comunidad (REFCO). Diseño: Estudio observacional con diseño transversal de tipo instrumental.
Evelyn M. Mamani-Vilca, Isabel P. Pelayo-Luis, Anali Terrones Guevara, Janett V. Chávez Sosa, Renzo Felipe Carranza-Esteban, Salomón Huancahuire-Vega   +5 more
doaj   +1 more source

Cell cycle regulation: p53-p21-RB signaling

Cell Death and Differentiation, 2022
The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms complexes with the E2F
K. Engeland
semanticscholar   +1 more source